Curcumin (Cur) possesses remarkable pharmacological properties, including cardioprotective, neuroprotective, antimicrobial, and anticancer activities. However, the utilization of Cur in pharmaceuticals faces constraints owing to its inadequate water solubility and limited bioavailability. To overcome these hurdles, there has been notable focus on exploring innovative formulations, with nanobiotechnology emerging as a promising avenue to enhance the therapeutic effectiveness of these complex compounds. We report a novel safe, effective method for improving the incorporation of anticancer curcumin to induce apoptosis by reducing the expression levels of miR20a and miR21. The established method features three aspects that, to our knowledge, have not been formally verified: (1) use of a novel formula to incorporate curcumin, (2) use of all biocompatible biodegradable materials to produce this formula without leaving harmful residues, and (3) an incorporation process at temperatures of approximately 50 °C. The formula was prepared from lecithin (LE), and chitosan (CH) with an eco-friendly emulsifying agent and olive oil as the curcumin solvent. The formula was converted to nanoscale through ultrasonication and probe sonication at a frequency of 20 kHz. Transmission electron microscopy showed that the nano formula was spherical in shape with sizes ranging between 49.7 nm in diameter and negative zeta potentials ranging from 28 to 34 mV. Primers miR20a and miR21 were designed for molecular studies. Nearly complete curcumin with an encapsulation efficiency of 91.1% was established using a straight-line equation. The nano formula incorporated with curcumin was used to prepare formulations that exhibited anticancer activities. The apoptosis pathway in cancer cells was activated by the minimum inhibitory concentration of the nano formula. These findings suggest the potential of this nanoformulation as an effective and selective cancer treatment that does not affect the normal cells.
This study were designed to make comparison between the influence alcoholic extract of Arctium lappa L. leaves and Pentoxifylline on treatment the adverse effect of gentamicin on DNA of sperms. Thirty five male rats were divided into 5 groups: the 1st group (T1) was made as negative control group, the 2nd group (T2) was given distilled water and gentamicin 5mg/kg (positive control group), the 3rd group (T3) was given a dose 600 mg/kg of Arctium lappa L and gentamicin, the 4th group (T4) was given dose 100mg/kg of pentoxifylline and gentamicin, the 5th group (T5) was given a dose 300mg/kg of Arctium lappa extract with dose 50mg/kg of pentoxifylline and gentamicin. The results of DNA damage% and agglutination % in T3, T4 and T5 appeared an
... Show MoreBackground: The purpose of this study was to evaluate and compare centering ability and canal transportation of simulated S-shaped canals instrumented with four different types of rotary nickel-titanium systems. Materials and Methods: Forty simulated S-shaped canals in resin blocks were divided into four groups of ten each and were instrumented to an apical size 25 by different instrumentation technique using ProTaper Universal files (group A), ProTaperNext (group B), Reciproc (group C) and WaveOne (group D).Centering ability and canal transportation was measured at (11) measuring points from D0 to D10 bysuperimposion of the pre- and post-operative images obtained by using digital camera in standardized manner. An assessment of the canals
... Show MoreImage texture is an important part of many types of images, for example medical images. Texture Analysis is the technique that uses measurable features to categorize complex textures. The main goal is to extract discriminative features that are used in different pattern recognition applications and texture categorization. This paper investigates the extraction of most discriminative features for different texture images from the “Colored Brodatz” dataset using two types of image contrast measures, as well as using the statistical moments on five bands (red, green, blue, grey, and black). The Euclidean distance measure is used in the matching step to check the similarity degree. The proposed method was tested on 112 classes o
... Show MoreThe phenomenon of child labor, any activity performed by a child and represents a contribution to the production, this phenomenon had been rife in Iraqi society, after that the proportion of child labor for the age group (6-14 years) amounting to 3% in 2006, became for the same age group of 8% in 2008*.
It is recognized that each phenomenon reasons, the phenomenon which our atten
... Show MoreA common problem facing many Application models is to extract and combine information from multiple, heterogeneous sources and to derive information of a new quality or abstraction level. New approaches for managing consistency, uncertainty or quality of Arabic data and enabling e-client analysis of distributed, heterogeneous sources are still required. This paper presents a new method by combining two algorithms (the partitioning and Grouping) that will be used to transform information in a real time heterogeneous Arabic database environment
This article investigates how an appropriate chaotic map (Logistic, Tent, Henon, Sine...) should be selected taking into consideration its advantages and disadvantages in regard to a picture encipherment. Does the selection of an appropriate map depend on the image properties? The proposed system shows relevant properties of the image influence in the evaluation process of the selected chaotic map. The first chapter discusses the main principles of chaos theory, its applicability to image encryption including various sorts of chaotic maps and their math. Also this research explores the factors that determine security and efficiency of such a map. Hence the approach presents practical standpoint to the extent that certain chaos maps will bec
... Show Moremodel is derived, and the methodology is given in detail. The model is constructed depending on some measurement criteria, Akaike and Bayesian information criterion. For the new time series model, a new algorithm has been generated. The forecasting process, one and two steps ahead, is discussed in detail. Some exploratory data analysis is given in the beginning. The best model is selected based on some criteria; it is compared with some naïve models. The modified model is applied to a monthly chemical sales dataset (January 1992 to Dec 2019), where the dataset in this work has been downloaded from the United States of America census (www.census.gov). Ultimately, the forecasted sales
In this paper, the blow-up solutions for a parabolic problem, defined in a bounded domain, are studied. Namely, we consider the upper blow-up rate estimate for heat equation with a nonlinear Neumann boundary condition defined on a ball in Rn.
Research in consumer science has proven that grocery shopping is a complex and distressing process. Further, the task of generating the grocery lists for the grocery shopping is always undervalued as the effort and time took to create and manage the grocery lists are unseen and unrecognized. Even though grocery lists represent consumers’ purchase intention, research pertaining the grocery lists does not get much attention from researchers; therefore, limited studies about the topic are found in the literature. Hence, this study aims at bridging the gap by designing and developing a mobile app (application) for creating and managing grocery lists using modern smartphones. Smartphones are pervasive and become a necessity for everyone tod
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