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Enhancing the therapeutic potential of curcumin: a novel nanoformulation for targeted anticancer therapy to colorectal cancer with reduced miR20a and miR21 expression
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Abstract<p>Curcumin (Cur) possesses remarkable pharmacological properties, including cardioprotective, neuroprotective, antimicrobial, and anticancer activities. However, the utilization of Cur in pharmaceuticals faces constraints owing to its inadequate water solubility and limited bioavailability. To overcome these hurdles, there has been notable focus on exploring innovative formulations, with nanobiotechnology emerging as a promising avenue to enhance the therapeutic effectiveness of these complex compounds. We report a novel safe, effective method for improving the incorporation of anticancer curcumin to induce apoptosis by reducing the expression levels of miR20a and miR21. The established method features three aspects that, to our knowledge, have not been formally verified: (1) use of a novel formula to incorporate curcumin, (2) use of all biocompatible biodegradable materials to produce this formula without leaving harmful residues, and (3) an incorporation process at temperatures of approximately 50 °C. The formula was prepared from lecithin (LE), and chitosan (CH) with an eco-friendly emulsifying agent and olive oil as the curcumin solvent. The formula was converted to nanoscale through ultrasonication and probe sonication at a frequency of 20 kHz. Transmission electron microscopy showed that the nano formula was spherical in shape with sizes ranging between 49.7 nm in diameter and negative zeta potentials ranging from 28 to 34 mV. Primers miR20a and miR21 were designed for molecular studies. Nearly complete curcumin with an encapsulation efficiency of 91.1% was established using a straight-line equation. The nano formula incorporated with curcumin was used to prepare formulations that exhibited anticancer activities. The apoptosis pathway in cancer cells was activated by the minimum inhibitory concentration of the nano formula. These findings suggest the potential of this nanoformulation as an effective and selective cancer treatment that does not affect the normal cells.</p>
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Publication Date
Sat Dec 01 2012
Journal Name
1st Scientific Conference Of Medical Group Colleges
carnal dimorphism of femur distal. extremity
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University of Baghdad college of Medicine - Cited by 1 - Human Anatomy

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Publication Date
Sat Jun 30 2007
Journal Name
Al-kindy College Medical Journal
Parental Perception of Fever in Children
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Back ground : Fever is a common medical problem in
children. parents have been shown unrealistic fears of
harmful effects of fever in their children. Resulting in
inappropriate management of fever in their children.
Objective: the objective of this study was to survey
parents about their knowledge andattitude concerning fever
in their children.
Methods : The study involved random selection of
parents who brought their febrile children to emergency
department or out-patient clinics of five teaching and non
teaching hospitals in Baghdad from first of October to end
of December 2002.
Parents of 400 febrile children were interviewed using a
standard questionnaire to obtain sociodemographic
informatio

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Publication Date
Sun Jun 03 2007
Journal Name
Al-kindy College Medical Journal
Parental perception of fever in children
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Back ground : Fever is a common medical problem in children. parents have been shown unrealistic fears of harmful effects of fever in their children. Resulting in inappropriate management of fever in their children. Objective: the objective of this study was to survey parents about their knowledge andattitude concerning fever in their children. Methods : The study involved random selection of parents who brought their febrile children to emergency department or out-patient clinics of five teaching and non teaching hospitals in Baghdad from first of October to end of December 2002. Parents of 400 febrile children were interviewed using a standard questionnaire to obtain sociodemographic information and current knowledge of fever. Results: Ap

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Publication Date
Fri Sep 01 2023
Journal Name
Journal Of Engineering
Kinetics of Fixed Bed Sorption Processes
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Adsorption and ion exchange are examples of fixed-bed sorption processes that show transient behavior. This means that differential equations are needed to design them. As a result, numerical methods are commonly utilized to solve these equations. The solution frequently used in analytical methods is called the Thomas solution. Thomas gave a complete solution that adds a nonlinear equilibrium relationship that depends on second-order reaction kinetics. A computational approach was devised to solve the Thomas model. The Thomas model's validity was established by conducting three distinct sets of experiments. The first entails the adsorption of acetic acid from the air through the utilization of activated carbon. Following

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Publication Date
Sun Sep 04 2011
Journal Name
Baghdad Science Journal
Jordan left (?,?) -derivations Of ?-prime rings
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It was known that every left (?,?) -derivation is a Jordan left (?,?) – derivation on ?-prime rings but the converse need not be true. In this paper we give conditions to the converse to be true.

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Publication Date
Sat Oct 01 2022
Journal Name
Al–bahith Al–a'alami
COMMUNICATIVE CONNOTATION OF PEPSI COLA ADS
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A trademark is one of the most valuable elements in advertising. At the same time, it is a guarantee for both the producer and the consumer. It prevents the mixing of products with a certain mark with similar products bearing another mark; and creates confidence in the goods of the product.

With the increase in the types of goods and products and the emergence of similar goods, producers have turned to the use of the brand to identify their products and seek perfection in manufacture to maintain quality and continuous improvement which ensures good reputation and fame.

Hence, commercials for goods and services focused on the brand because they give in-depth connotations with the recipients of these ads. T

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Publication Date
Fri Aug 22 2025
Journal Name
Full Text Book Of Xv. International Scientific Congress Of Pure, Applied And Technological Sciences
Full Text Book of Minar Congress15
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One of the crucial public health problems worldwide is the urinary tract infections (UTIs) that are derived from uropathogenic bacteria (UPBs). Slime layer is known to have the ability to permit bacteria to achieve smooth surfaces attachment like catheters and prosthetic implants which in turn, facilitate biofilm formation and may cause lethal infections. On the other hand, Extended-spectrum beta-lactamase (ESBL) production is considered a growing concern among UPBs due to the limiting of the treatment options and contributes to resistance toward antibiotics. The principal study's point is the finding out the slime layer and ESBL production in Escherichia coli and Klebsiella pneumoniae of uropathogenic origin. Ten ready isolates (five isola

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Crossref
Publication Date
Wed Aug 01 2007
Journal Name
University Of Baghdad, College Of Education For Pure Science (ibn Al-haitham), Department Of Mathematical
Thesis.On Solvability of an Operator Equation-
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Publication Date
Wed May 17 2023
Journal Name
College Of Islamic Sciences
Compilers of Hanbali jurisprudence (Abbasid era)
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This large book represents the research and is marked (Compilers of Hanbali jurisprudence of the Abbasid era). It includes, between its covers, a large group of scholars of the Islamic nation, with its great jurists and mujtahids, from the followers of the school of (Ahmed bin Hanbal) in the fundamentals and branches, and specific to the sciences of the Qur’an, its jurisprudence, and the narrators of the hadiths of the Noble Prophet The best of creation (Muhammad) peace and blessings be upon him, and it also includes a large number of reciters and ascetics, who are known for their abundance of authorship, especially with regard to the collection and numbers of classifications, and they are too large to be counted by number! But can we

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Publication Date
Sun Mar 30 2003
Journal Name
Iraqi Journal Of Chemical And Petroleum Engineering
Performance of Countercurrent Flow Cooling Towers
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