Preferred Language
Articles
/
cRfllpABVTCNdQwCP475
TERATOGENIC EFFECT OF METHOTREXATE ON HISTOGENESIS OF TESTIS IN NEWBORN RAT
...Show More Authors

Background: Methotrexate (MTX) was one of the first drugs synthesized for a specific chemotherapeutic purpose used to inhibit folic acid (FA) for the treatment of acute lymphoblastic leukemia in children. Its history is closely related to the discovery and characterization of folic acid. It is used clinically in medicine to treat a range of cancerous and noncancerous conditions. MTX is currently used in gynecology to treat disorders arising from trophoblastic tissue, namely, ectopic pregnancy. MTX, the most frequently used diseasemodifying anti-rheumatic drug (DMARD), suppresses disease activity and reduces joint damage. The aim of study: It is designed to demonstrate the effect of MTX (7.5 mg/wk.) on the histogenesis of gonad (testis) of newborn Albino rat. Material & Methods: Twenty pregnant female rats taken, classified equally to 10 control and 10 treated with MTX intramuscularly (first dose at day 15 of gestation and second dose at two day after birth). After normal vaginal delivery, newborns harvested at day seven. For histological study the newborn gonad (testis) were fixed in Bouin’s fixative, paraffin infiltration, and then embedded sections stained with haematoxylin and eosin, the specimens independently read. The result: The histological investigation showing atrophy of seminiferous tubules, increase interstitial space with reduce interstitial connective tissue and leydig cell, destruction of basement membrane, complete detachment of spermatogenic cell from basement membrane, atrophy of spermatogenic cell, swelling spermatogenic cell, degeneration sertoli and leydig cell, cell death, congested blood vessels and hemorrhage. The statistical analysis at day seven shown significant decrease (P<0.05) in newborn weight compared with control group. Highly significant increase (P<0.001) in diameter of testes. Significant decrease (P<0.01) in diameter of seminiferous tubules. Significant decrease (P<0.05) in numbers of spermatogenic cell in seminiferous tubules. The conclusion: The findings of the present study show that therapeutic dose of methotrexate is capable of producing histological changes in newborn’s testis at day seven

Publication Date
Tue Jan 02 2018
Journal Name
Journal Of Educational And Psychological Researches
The effect of recent technology on university students’ skills
...Show More Authors

The study aims to identify the students’ attitudes toward recent techniques’ use in teaching; using power point software and data show to facilitate teaching approaches as well as following the approach of lecture in giving subjects, do these techniques facilitate, increase, and tackle the difficulties of subjects, do these attitudes positive or negative?, and to what extent these techniques raise up students’ motivation.   

View Publication Preview PDF
Publication Date
Wed Jan 01 2020
Journal Name
Systematic Reviews In Pharmacy
The effect of silver nanoparticles on braf gene expression
...Show More Authors

The recent studies suggested the possible toxicities or genetic alterations associated with biological and medical applications of silver nanoparticles (AgNPs). The current research is directed to see if AgNPs administration can lead to some changes in expression of BRAF gene in selected body organs tissues. Fifty-six male of musmusculs (Balb/C) mice from the animal house of Al-Nahrain Centre of Biotechnology were used. These animals were divided randomly to seven groups (eight mouse in each group), one of these groups represented the control group, three groups were subjected to different doses of AgNPs (0.25, 0.5and 1 mg/kg of body weight) for one week, and the remaining three groups were subjected to three different doses of AgNP

... Show More
Preview PDF
Scopus (6)
Scopus
Publication Date
Tue Jan 01 2019
Journal Name
Plant Archives
Effect of foliar spraying with bilirubin on maize growthandyield
...Show More Authors

Scopus (3)
Scopus
Publication Date
Mon Mar 08 2021
Journal Name
Baghdad Science Journal
The Effect of Grain Boundaries on Schottky Diode Parameters
...Show More Authors

The activation energy and optical band gap of different regions (p-type) polysilicon have been measured. Both microscopic studies and current-voltage characteristics of diodes prepared on different surface regions were carried out. Comparison of diodes parameters and microscopic studies indicate that the type of angles between boundaries has a significant effect on diodes parameters while the boundary lengths per unit area has less effect. The mechanism of Al-interaction with grain boundaries and their intersecting points at different temperature were also studies. The X-ray fluorescence spectrometry has been used for detection of diffused A1%.

View Publication Preview PDF
Publication Date
Mon Jan 01 2024
Journal Name
Aip Conference Proceedings
Gamma irradiation effect on characterization of MoO3 nanostructures films
...Show More Authors

View Publication
Scopus Crossref
Publication Date
Wed Mar 10 2021
Journal Name
Baghdad Science Journal
the effect of doping ratio on the opical properties
...Show More Authors

the films of cdse pure and doped with copper ratio glass substrate effect od cucomcentration technique thikness doped with copper is an anonmg and the density of state increases

View Publication Preview PDF
Publication Date
Sun Dec 04 2011
Journal Name
Baghdad Science Journal
Dopping Effect on Optical Constant of Poly (Vinyl Chloride)
...Show More Authors

Thick films of poly(vinyl chloride)(PVC)& PVC doped with Zn(etx)2 salt complex have been prepared by cast method with fixed thickness almost (120±5) Microns. Optical studies were carried out in the wavelengths region(200-900)nm based on absorption & transmition measurement. Optical parameters such as absorption coefficient(?) ,refraction index(n) and extinction coefficient(K) were observed to be effected by adding the dopant.Electrical parameters such as real(?)& imaginary(?) part of dielectric constant were also calculated part of dielectric constant were also calculated from the optical parameters using Maxwell equation.

View Publication Preview PDF
Crossref
Publication Date
Mon Jun 26 2017
Journal Name
Journal Of Contemporary Medical Sciences
Antimicrobial effect of probiotic Lactobacillus spp. on Pseudomonas aeruginosa
...Show More Authors

View Publication Preview PDF
Crossref (15)
Crossref
Publication Date
Sat Jun 01 2013
Journal Name
Engineering And Technology Journal
Effect of External Sulfate Attack on Self Compacted Concrete
...Show More Authors

Self-compacting concrete (SCC) is an innovative concrete that does not require vibration for placing and compaction. It is able to flow under its own weight, completely filling formwork and achieving full compaction, even in the presence of congested reinforcement. The effect of external sulfate attack was studied-Es (very sever exposure SO4>10000ppm) according to ACI 318-11. The mix design method of SCC used is according to EFNARC 2002, and then must satisfy the criteria of filling ability, passing ability and segregation resistance. The experimental program focuses to study two different chemical composition of sulfate resistance Portland cement with different percentage of silica fume replacement by weight of cement and W/cm (0.3 and 0.3

... Show More
Preview PDF
Publication Date
Thu Jun 01 2023
Journal Name
Iraqi Journal Of Cancer And Medical Genetics
Effect of DNA damage mediating psychosocial stress on aging
...Show More Authors

Adversity and psychosocial stress are involved in aging through the following pathways. psychological stress enhances the nerve system to secrete endocrine mediators (hormones). Mitochondrial respiration mediates energy production stimulated by binding to these hormones to their receptors. Energy produced by mitochondria accelerates metabolism and, in its turn, leads to increases in reactive oxygen species (ROS) of free radicals. Cellular stress and accumulation of damage can result from an excess of ROS. Accumulation of damage comprises damages in telomeric and nontelomeric DNA, in addition to mitochondrial DNA. Mitochondrial DNA damage plays an important role in increasing the pathway of p53/p21. The expression of the PGC-1α gene

... Show More
View Publication
Crossref