Flexible molecular docking is a computational method of structure-based drug design to evaluate binding interactions between receptor and ligand and identify the ligand conformation within the receptor pocket. Currently, various molecular docking programs are extensively applied; therefore, realizing accuracy and performance of the various docking programs could have a significant value. In this comparative study, the performance and accuracy of three widely used non-commercial docking software (AutoDock Vina, 1-Click Docking, and UCSF DOCK) was evaluated through investigations of the predicted binding affinity and binding conformation of the same set of small molecules (HIV-1 protease inhibitors) and a protein target HIV-1 protease enzy

In this paper, a compact genetic algorithm (CGA) is enhanced by integrating its selection strategy with a steepest descent algorithm (SDA) as a local search method to give I-CGA-SDA. This system is an attempt to avoid the large CPU time and computational complexity of the standard genetic algorithm. Here, CGA dramatically reduces the number of bits required to store the population and has a faster convergence. Consequently, this integrated system is used to optimize the maximum likelihood function lnL(φ1, θ1) of the mixed model. Simulation results based on MSE were compared with those obtained from the SDA and showed that the hybrid genetic algorithm (HGA) and I-CGA-SDA can give a good estimator of (φ1, θ1) for the ARMA(1,1) model. Anot

The physical behavior for the energy distribution function (EDF) of the reactant particles depending upon the gases (fuel) temperature are completely described by a physical model covering the global formulas controlling the EDF profile. Results about the energy distribution for the reactant system indicate a standard EDF, in which it’s arrive a steady state form shape and intern lead to fix the optimum selected temperature.

The issue of communication and communication is receiving increasing attention in both contemporary studies and educational literature, and these studies emphasize the importance of studying communication within the classroom, which inevitably applies to the importance of relationships and tensions in the field of teaching art in particular because it is an emotional field that provides an opportunity for communication competencies and skills to be prominent and take Its wide scope, both among the students themselves and between teachers and students. The means of communication are the vessel in which the cultural relations and the commonalities between people revolve. The process of building relationships between students depends in man

problem of the research is the decline of the role of urban space with time as an influential system in societal relations. The research aims to define indicators for achieving social interaction in the city, and to determine indicators for achieving integration in the urban space, and to study the relationship between the integration of urban space and community interaction over time. the research assumed that by distinguishing the social interaction space from the urban space and developing urban spaces in order to be truly interactive spaces, this will help us achieve social interaction and build a positive relationship between them, which enables us to achieve integration within the urban spaces leading to social interaction. Because

The aim of this paper is to design fast neural networks to approximate periodic functions, that is, design a fully connected networks contains links between all nodes in adjacent layers which can speed up the approximation times, reduce approximation failures, and increase possibility of obtaining the globally optimal approximation. We training suggested network by Levenberg-Marquardt training algorithm then speeding suggested networks by choosing most activation function (transfer function) which having a very fast convergence rate for reasonable size networks.             In all algorithms, the gradient of the performance function (energy function) is used to determine how to

     In this work, the methods (Moments, Modified Moments, L-Moments, Percentile, Rank Set sampling and Maximum Likelihood) were used to estimate the reliability function and the two parameters of the Transmuted Pareto (TP) distribution. We use simulation to generate the required data from three cases this indicates  sample size , and it replicates  for the real value for parameters, for reliability times values  we take .

Results were compared by using mean square error (MSE), the result appears as follows :

The best methods are Modified Moments, Maximum likelihood and L-Moments in first case, second case and third case respectively.

     A multivariate control chart is measured by many variables that are correlated in production, using the quality characteristics in any product. In this paper, statistical procedures were employed to find the multivariate quality control chart by utilizing fuzzy Hotelling  test. The procedure utilizes the triangular membership function to treat the real data, which were collected from Baghdad Soft Drinks Company in Iraq. The quality of production was evaluated by using a new method of the ranking function.

Objectives: To assess general social factors for elderly in geriatric homes in Jordan.
Methodology: The study was conducted for clients residing in elderly homes. A purposive sample of (155)
residents were selected. Social resource scale by (Duck University Center) called (OARA) older adult resources
and services was used as tool for data collection. The questions extract data about family structure, patterns of
friends and visiting, availability of a confident, satisfaction with the degree of social interaction and availability
of a helper in the event of illness or disability and the program of trips in the houses.
Results: The findings revealed that the life expectancy for women is greater than for men. In respect to