Preferred Language
Articles
/
bsj-7405
Synthesis, characterization, molecular docking, ADMET prediction, and anti-inflammatory activity of some Schiff bases derived from salicylaldehyde as a potential cyclooxygenase inhibitor
...Show More Authors

A series of Schiff base-bearing salicylaldehyde moiety compounds (1-4) had been designed, synthesized, subjected to insilico ADMET prediction, molecular docking, characterization by FT-IR, and CHNS analysis techniques, and finally to their Anti-inflammatory profile using cyclooxygenase fluorescence inhibitor screening assay methods along with standard drugs, celecoxib, and diclofenac. The ADMET studies were used to predict which compounds would be suitable for oral administration, as well as absorption sites, bioavailability, TPSA, and drug likeness. According to the results of ADME data, all of the produced chemicals can be absorbed through the GIT and have passed Lipinski’s rule of five. Through molecular docking with PyRx 0.8, these synthesized compounds were tested insilico selectivity toward COX-1 and COX-2 and in vitro for their anti-inflammatory efficacy . In vitro testing demonstrated that all of the produced compounds had significantly stronger activity against the COX-2 enzyme than COX-1. Among these, compound 1 displayed the most potent inhibitory activity with an IC50 value of 0.19 µM compared to standard drug celecoxib (IC50 = 0.29 µM). The most active derivative compound1 was oriented towards the active site and occupied the target enzyme based on the docking investigation against COX-1 and COX-2. In addition, insilico investigations found that COX-2 has a higher inhibitory activity than COX-1

Scopus Crossref
View Publication Preview PDF
Quick Preview PDF
Publication Date
Thu Dec 30 2021
Journal Name
Iraqi Journal Of Science
Learning Evolution: a Survey
...Show More Authors

     Learning is the process of gaining knowledge and implementing this knowledge on behavior. The concept of learning is not strict to just human being, it expanded to include machine also. Now the machines can behave based on the gained knowledge learned from the environment. The learning process is evolving in both human and machine, to keep up with the technology in the world, the human learning evolved into micro-learning and the machine learning evolved to deep learning. In this paper, the evolution of learning is discussed as a formal survey accomplished with the foundation of machine learning and its evolved version of learning which is deep learning and micro-learning as a new learning technology can be imple

... Show More
View Publication Preview PDF
Scopus (7)
Crossref (2)
Scopus Crossref
Publication Date
Wed Sep 30 2015
Journal Name
College Of Islamic Sciences
A consensus on measurement
...Show More Authors

Many letters and theses written on the subject of consensus, as well as in measurement,
But we tried to address a topic of consensus

Building a blind measuring guide.
 We have tried to explain the meaning of convening, then the statement of consensus in language and terminology and then the statement of measurement
Also, we have shown the types of consensus mentioned by the jurists, and this is how much was in the first topic, either
The second section included the statement of the doctrines of the blind in the matter, and then the evidence of each doctrine and discussed.
We followed it with the most correct opinion statement and concluded the research with some of the conclusions we reached through
search.

... Show More
View Publication Preview PDF
Publication Date
Thu Dec 01 2022
Journal Name
Scientific Research Journal Of Engineering And Computer Science
Cryptography Techniques - A Review
...Show More Authors

l

Publication Date
Sat Dec 30 2023
Journal Name
Iraqi Journal Of Science
Unsteady Heat Transfer Analysis on The MHD Flow of A Second Grade Fluid in A Channel with Porous Medium
...Show More Authors

The aim of this paper is to analyzed unsteady heat transfer for magnetohydrodynamic (MHD) flow of a second grade fluid in a channel with porous medium. The equations which was used to describe the flow are the momentum and energy, these equations were written to get thier non dimentional form. Homotopy analysis method (HAM) is employed to obtain a semi-analytical solutions for velocity and heat transfer fields. The effect of each dimensionless parameter upon the velocity and temperature distributions is analyzed and shown graphically by using MATHEMATICA package.

View Publication Preview PDF
Publication Date
Tue Aug 23 2022
Journal Name
Frontiers In Energy Research
Evaluation of T-Shaped Fins With a Novel Layout for Improved Melting in a Triple-Tube Heat Storage System
...Show More Authors

The effects of T-shaped fins on the improvement of phase change materials (PCM) melting are numerically investigated in vertical triple-tube storage containment. The PCM is held in the middle pipe of a triple-pipe heat exchanger while the heat transfer fluid flows through the internal and external pipes. The dimension effects of the T-shaped fins on the melting process of the PCM are investigated to determine the optimum case. Results indicate that while using T-shaped fins improves the melting performance of the PCM, the improvement potential is mainly governed by the fin’s body rather than the head. Hence, the proposed T-shaped fin did not noticeably improve melting at the bottom of the PCM domain; additionally, a flat fin is ad

... Show More
View Publication
Scopus (20)
Crossref (14)
Scopus Clarivate Crossref
Publication Date
Fri Sep 01 2023
Journal Name
Al-khwarizmi Engineering Journal
A Study on the Effect of Multistage Toolpath in Fabricating a Customized Cranial Implant in Incremental Sheet Metal Forming
...Show More Authors

Incremental sheet forming (ISF) process offers a high degree of flexibility in the manufacturing of different sheet parts, which makes it an ideal candidate for prototype parts as well as efficient at fabricating various customized products at low production costs compared to traditionally used processes. However, parts produced in this process exhibit notable geometrical inaccuracy and considerable thickness reduction. In this paper, the single point incremental sheet forming variant of the process has been implemented to manufacture a highly customized cranial implant starting from the computed tomography (CT) scan data of the patient's anatomy. A methodology, from the modeling to the realization of the implant, is presented and discus

... Show More
View Publication Preview PDF
Crossref (1)
Crossref
Publication Date
Thu Apr 01 2021
Journal Name
Computer Methods And Programs In Biomedicine
A hybrid approach based on multiple Eigenvalues selection (MES) for the automated grading of a brain tumor using MRI
...Show More Authors

View Publication
Scopus (35)
Crossref (32)
Scopus Clarivate Crossref
Publication Date
Mon May 27 2019
Journal Name
Al-academy
A Hypothesis of Architectural Environment Exercise for Actor Training (Continuous exercise space workshop – A model): هيثم عبد الرزاق علي
...Show More Authors

The peculiarity of the theater does not lie in its dramatic content because many literary genres and other artistic styles share with it in this content. The peculiarity of the theater lies in contemplating the drama through what is architectural, and this architectural axis is what distinguishes its character. It is a spatial poetry which is composed by the laws of physics and chemistry, (Weight, height, distance, rhythm, gravity, impulses and chemical excretions). i.e., what cannot be expressed in words. This is a game of space to exchange and organize energy and communicate in space by the living body, which contains the possibilities of the living drawing in space: in the time and place. This research deals with the importance of the

... Show More
View Publication Preview PDF
Crossref
Publication Date
Sat Oct 01 2022
Journal Name
Al–bahith Al–a'alami
DOMINATION OF CONTENT OVER FORM IS ONE OF THE PROBLEMS OF CHILDREN’S STORIES IN IRAQ
...Show More Authors

 

The stories of children in Iraq during the past two decades have received a number of important scientific studies. Despite tyranny of the historical study method on most of these studies, they have been and still are very important, because they have established a chronicle of this literary style that has been neglected and based not only on the academic level and serious in-depth university studies but also on the enclosed sight that doesn’t consider studied art as an innovation with its specificity and its typical technical components. While many of the public impressions and self-reflections contributed to the dominance of some of the provisions and concepts that were circulated as critical remarks and adopted by som

... Show More
View Publication Preview PDF
Crossref
Publication Date
Sun Apr 05 2015
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Cancer in infancy: Experience of Children Welfare Teaching Hospital, Medical City Complex, Baghdad
...Show More Authors

Background: It is becoming increasingly apparent that the study of infant cancer may lead to further understanding of the mechanisms of carcinogenesis, due to the unique clinical, genetic, and epidemiologic characteristics of cancer in infant.
Objectives: To study the clinical and pathological presentation of infants with cancer, their outcome and survival.
Patients & methods: A retrospective study was done over a 6 years period between (Jan.1st.2001- Dec. 31st. 2006), reviewed the records of 85 infants diagnosed and treated in oncology unit, children welfare teaching hospital, medical city-Baghdad.
Results: The majority of patients 57(67%) were from Baghdad & surrounding provinces; Leukemia was the most common type of c

... Show More
View Publication Preview PDF
Crossref