Cytokines are signaling molecules between inflammatory cells that play a significant role in the pathogenesis of a disease. Among these cytokines are interleukins (ILs) 17A and 33, and accordingly, the current case-control study sought to investigate the role of each of the two cytokines in the risk of developing multiple sclerosis (MS). Sixty-eight relapsing-remitting MS (RRMS) Iraqi patients and twenty healthy individuals (control group) were enrolled. Enzyme linked immunosorbent assay (ELISA) kits were used to determine serum levels of IL-17A and IL-33. Results revealed that IL-17A and IL-33 levels were significantly higher in MS patients than in controls (14.1 ± 4.5 vs. 7.5 ± 3.8 pg/mL; p < 0.001 and 65.3 ± 16.3 vs. 49.3 ± 20.0 pg/mL; p < 0.001, respectively). Receiver operating characteristic (ROC) curve analysis demonstrated that IL-17A was a very good predictor of MS (area under curve [AUC] = 0.869; 95% CI = 0.779 - 0.960; p < 0.001; cut-off value = 10.2 pg/mL; sensitivity = 80.8%; specificity = 75.0%). A similar prediction was presented by IL-33, but the AUC value was lower (AUC = 0.762; 95% CI = 0.63 - 0.89; p < 0.001; cut-off value = 56.4 pg/mL; sensitivity = 70.6%; specificity = 70.0%). Multinomial logistic regression analysis confirmed the significance of IL-17A and IL-33 in MS risk, and under three models of analysis, the estimated odds ratios for IL-17A (1.50, 1.49 and 1.50, respectively) and IL-33 (1.05, 1.05 and 1.06) were above 1.0. Patients stratified by gender (male and female), expanded disability status scale (EDSS: < 3 and ≥ 3) or medication (pre- and post-medication) showed no significant differences in serum levels of IL-17A and IL-33 for each stratum. However, with regard to response to medication, it was found that responding patients showed significantly higher levels of IL-33 than non-responders (70.9 ± 12.2 vs. 57.2 ± 18.2 pg/mL; p = 0.018). This difference was not observed when considering IL-17A. Pearson correlation analysis between IL-17A and IL-33 revealed that both cytokines were not significantly correlated. In conclusion, the study indicated that IL-17A and IL-33 were up-regulated in serum of MS patients, and this up-regulation was not influenced by age, gender, EDSS or medication status, but the elevated level of IL-33 was more pronounced in patients who responded to medication.
يعد الذكاء الاصطناعي من العلوم الحديثة التي ارتبطت بالإنسان منذ العقود الخمسة الماضية، ولتصبح السياسة الرقمية الاقتصادية جزءاً لا يتجزأ من المجتمع، لكونها خرقت أغلب مجالات حياة الانسان. وهذا ما شجع صانعوا السياسات التكنولوجية الجديدة في التفكير بكيفية توظيفه لخدمة مصالحهم الاقتصادية العُليا، بغض النظر عن بذل الجهود للتفكير في مصالح الانسان الاقتصادية وتنظيمهم ومراقبة الذكاء الاصطناعي التوليدي. لقد أيقن
... Show MoreThis Kind of study has a special importance. Great numbers of Arab Muslims share a lot of their work, their Trans lations & new additions to scientific heritage. They facilitate the indirect way for Europeans to got Greek scientific knowledge. Ibn Sina classified & collected in his book (Law) Galen`s medical publications & he clarified, arranged & make them easy to understand.
تم ت داول مصطلح الأزمة ا دلولية في السياسية ا دلولية خال القرن التاسع عش ر لتحدي دا ملدة الانتقالية بين السلم والحرب سواء أ دت الأزمة إلى نشوب صراع مسلح أم مت ت ت سويتها بالطرق السلمية، وتع دالأزمة ا دلولية مرحلة مت هيدية ل لحرب وهي ا رملحلة التي يسعى فيها أ طرا فالأزمة إلى إبعاد احتمالية نشوء أ و اندلاع الحرب، فالأزمة ه ي مدة حرجة ومرحلة خطيرة بين وقتي السلم والحرب، إن العلاقات ا دلولية تكاد ت عيشأ زمات متلاحقة ع
... Show MoreSeemed reflections of cultural globalization are clear on the values of communities those values that preserve each community privacy, so that became members of these communities lack the ability to distinguish clearly between what is right and what is wrong and adoption of ideas and values imported from abroad, regardless of whether positive or negative. The aim of the research was to: - 1 - Detection of cultural globalization in the educational values for students kindergarten section. 2 - To identify the most prominent educational values (social, scientific, aesthetic, moral and spiritual) globalized culture. The current Aqtsralbges on: - Department of kindergarten students to study in the morning College for Girls, Baghdad University
... Show Moreمثل الوعي الطبقي اعلى مراحله لدى الفكر الماركسي الحديث عند كل من ماركس وانجلز ولينين ليس مجرد انعكاس للواقع وانما يكون بصورة جدلية من خلال انعكاس الوعي على الواقع واعادة انتاجه فبعد ان كان الوعي هو نتاج تطور الواقع اصبح اداة في تطوير الواقع، أي تأثير البنى الفوقية على البنى التحتية( المادية التاريخية) بعكس ما دعى اليه ماركس، اذ أعطى لينين للوعي دوراً كبيرا في التطور التاريخي، وعد الوعي الطبقي هو الاداة التي
... Show MoreThe organization and development of the irrigation system and agrarian reform in Iraq had an impact on the diversity of its methods and uses.
There was a huge role in the history of a muslim woman and several books have mentioned that politically or in religion and even scientifically and socially which leaded a lot of women to look up to these women who helped in keeping the religion just in the right form for other generations
The shortcomings of the Muslim regime were however, became more obvious in later periods. Under the first Abbasids, the Muslims bourgeoisies were still a new class, rising in the social hierarchy of the caliph empire. It became even powerful class and a factor to reckon with