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bsj-6431
Predictive Significance of Interleukins 17A and 33 in Risk of Relapsing–Remitting Multiple Sclerosis
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Cytokines are signaling molecules between inflammatory cells that play a significant role in the pathogenesis of a disease. Among these cytokines are interleukins (ILs) 17A and 33, and accordingly, the current case-control study sought to investigate the role of each of the two cytokines in the risk of developing multiple sclerosis (MS). Sixty-eight relapsing-remitting MS (RRMS) Iraqi patients and twenty healthy individuals (control group) were enrolled. Enzyme linked immunosorbent assay (ELISA) kits were used to determine serum levels of IL-17A and IL-33. Results revealed that IL-17A and IL-33 levels were significantly higher in MS patients than in controls (14.1 ± 4.5 vs. 7.5 ± 3.8 pg/mL; p < 0.001 and 65.3 ± 16.3 vs. 49.3 ± 20.0 pg/mL; p < 0.001, respectively). Receiver operating characteristic (ROC) curve analysis demonstrated that IL-17A was a very good predictor of MS (area under curve [AUC] = 0.869; 95% CI = 0.779 - 0.960; p < 0.001; cut-off value = 10.2 pg/mL; sensitivity = 80.8%; specificity = 75.0%). A similar prediction was presented by IL-33, but the AUC value was lower (AUC = 0.762; 95% CI = 0.63 - 0.89; p < 0.001; cut-off value = 56.4 pg/mL; sensitivity = 70.6%; specificity = 70.0%). Multinomial logistic regression analysis confirmed the significance of IL-17A and IL-33 in MS risk, and under three models of analysis, the estimated odds ratios for IL-17A (1.50, 1.49 and 1.50, respectively) and IL-33 (1.05, 1.05 and 1.06) were above 1.0. Patients stratified by gender (male and female), expanded disability status scale (EDSS: < 3 and ≥ 3) or medication (pre- and post-medication) showed no significant differences in serum levels of IL-17A and IL-33 for each stratum. However, with regard to response to medication, it was found that responding patients showed significantly higher levels of IL-33 than non-responders (70.9 ± 12.2 vs. 57.2 ± 18.2 pg/mL; p = 0.018). This difference was not observed when considering IL-17A. Pearson correlation analysis between IL-17A and IL-33 revealed that both cytokines were not significantly correlated. In conclusion, the study indicated that IL-17A and IL-33 were up-regulated in serum of MS patients, and this up-regulation was not influenced by age, gender, EDSS or medication status, but the elevated level of IL-33 was more pronounced in patients who responded to medication.

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Publication Date
Fri Feb 08 2019
Journal Name
Journal Of The College Of Education For Women
بدایات الفكر الجمھوري في العراق 1908 - 1921 دراسة تاريخية
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The main target of this research is to follow the stages of the emergence of
the idea of republican form of government from its very beginning , yet there
were many elements from different estates thinker , educated , few of heads of
clans . This first opportunity for the mobilization of politically-minded people
with fundamental activity like najei shokat . hussain al-rahal notable poet maruf
al-rasafi those who formed what so called the political elite who believed in
constitutional , democratic parliamentary republic , one of them was al-rahal who
called for a constitutional republic even before the emergence of the
constitutional movement in Iran and ottoman empire (1908).
The holy najaf become cultural cen

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Publication Date
Mon Oct 22 2018
Journal Name
Arab Science Heritage Journal
الفلاسفة الفلاسفة وآراؤهم في العقل وعلاقته بالنفس والروح والقلب
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In this research  I  like  to shed  light on the mind  because  of its  importance  because  it is  what  distinguishes  Human  from all  other  animals and  that  the question  and  status  comes  from his role in the  formulation  of  knowledge  and  science  where the  machers  agreed  that  the word of  mind  in  its  general  sense  is the  source  of  thought  and  thought  and the instrument  of  faith  and  philosophy , Then to the statement  of the  various  stages  pass

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Publication Date
Mon Jul 01 2024
Journal Name
مجلة نسق
الإدمان في منظور قوة علم النفس الإيجابي وطرائق الوقاية
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Publication Date
Tue Jan 30 2018
Journal Name
مجلة جامعة الانبار للعلوم القانونية والسياسية
الحماية المدنية للمستهلك في المرحلة السابقة على التعاقد الالكتروني
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يتناول البحث الحماية المدنية للمستهلك في المرحلة السابقة على التعاقد الالكتروني

Publication Date
Sun Jan 11 2026
Journal Name
Imam Jaafar Al-sadiq University Journal Of Human And Social Sciences
الادارة الالكترونية الناجحة ودورها في حل مشكلات الادارة العامة
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Publication Date
Thu Oct 01 2015
Journal Name
Journal Of Educational And Psychological Researches
دور الإرشاد النفسي في تحقيق جودة الحياة بالمجتمع المعاصر
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     Psychological Counseling Services occupies a high position in the developed countries and that for its psychologist services for different sectors of the community members, and has been popularized until recently the wrong concept of the effect, that the psychological service is provided only to the owners of behavior is normal only, Vantage him neglect to provide psychological services a large segment of the community members who are in dire need of these services.

      The counseling service is part of a global social movement seeking to emphasize the quality of life of the human and the emphasis on the value and dignity and the need to live a quiet lif

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Publication Date
Mon Nov 19 2018
Journal Name
Arab Science Heritage Journal
مفهوم مفهوم التاريخ الطبيعي لحشرة النحل في التراث الإسلامي
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The insects like other creatures in the wide world, and there are more than a million class and type of these objects, some of which human haunted since the old to the present day.

 In this study highlight the insect bee addressing her life and behavior, and the novelty of her and wonders what mystified by the minds of men that her world is full of mysteries and surprises drew the attention of workers in the natural history of the study and scrutiny of methods and different characteristics of scientists as she gives more than it takes. It appeared that the Islamic heritage has singled out these insects with something of interest and precise detail, but that God Almighty made suras from the Koran carrying insect name two Sura

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Publication Date
Mon Jan 07 2013
Journal Name
Journal Of Educational And Psychological Researches
انحراف الشخصية بحث ميداني في قضاء المدائن لمدينة بغداد
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This search modest deviation personal than to doubt that the event was not guilty by nature or offenders of evil in origin but is arictim of misfortune that makes him grow or live in the center of the corruption, even if he could be in the middle of the blessing of good and virtue and reform lived living righteousness and honor it was  a useful member for himself and his community and must state and family community take hands mnhrfaite in order to prevent and provide then

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Publication Date
Wed Nov 28 2018
Journal Name
Arab Science Heritage Journal
الصناعة الصناعة في بغداد للفترة (334هـ /935م -555هـ/ 1160م)
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The industries in Baghdad, the most important economic activities in the era albeit and Seljuk to the availability of manpower and resources which encourage the establishment of these industries in Baghdad.

These industries seam as simple crafts, but they may have influenced the nature of the social and economic life in the Baghdadi community during the foreign authority on Iraq and general in Baghdad in particular.

 

 

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Publication Date
Tue Nov 13 2018
Journal Name
Arab Science Heritage Journal
المجتمع المجتمع الاسكندري: عاداته وتقاليده الاجتماعية في العصر المملوكي
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It is important to study that the social circumstances in Alexandria through  Mamluk era specially social life in Egypt specially in Alexandria  which had describe as it was show change in opposite with other sides of life

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