Cytokines are signaling molecules between inflammatory cells that play a significant role in the pathogenesis of a disease. Among these cytokines are interleukins (ILs) 17A and 33, and accordingly, the current case-control study sought to investigate the role of each of the two cytokines in the risk of developing multiple sclerosis (MS). Sixty-eight relapsing-remitting MS (RRMS) Iraqi patients and twenty healthy individuals (control group) were enrolled. Enzyme linked immunosorbent assay (ELISA) kits were used to determine serum levels of IL-17A and IL-33. Results revealed that IL-17A and IL-33 levels were significantly higher in MS patients than in controls (14.1 ± 4.5 vs. 7.5 ± 3.8 pg/mL; p < 0.001 and 65.3 ± 16.3 vs. 49.3 ± 20.0 pg/mL; p < 0.001, respectively). Receiver operating characteristic (ROC) curve analysis demonstrated that IL-17A was a very good predictor of MS (area under curve [AUC] = 0.869; 95% CI = 0.779 - 0.960; p < 0.001; cut-off value = 10.2 pg/mL; sensitivity = 80.8%; specificity = 75.0%). A similar prediction was presented by IL-33, but the AUC value was lower (AUC = 0.762; 95% CI = 0.63 - 0.89; p < 0.001; cut-off value = 56.4 pg/mL; sensitivity = 70.6%; specificity = 70.0%). Multinomial logistic regression analysis confirmed the significance of IL-17A and IL-33 in MS risk, and under three models of analysis, the estimated odds ratios for IL-17A (1.50, 1.49 and 1.50, respectively) and IL-33 (1.05, 1.05 and 1.06) were above 1.0. Patients stratified by gender (male and female), expanded disability status scale (EDSS: < 3 and ≥ 3) or medication (pre- and post-medication) showed no significant differences in serum levels of IL-17A and IL-33 for each stratum. However, with regard to response to medication, it was found that responding patients showed significantly higher levels of IL-33 than non-responders (70.9 ± 12.2 vs. 57.2 ± 18.2 pg/mL; p = 0.018). This difference was not observed when considering IL-17A. Pearson correlation analysis between IL-17A and IL-33 revealed that both cytokines were not significantly correlated. In conclusion, the study indicated that IL-17A and IL-33 were up-regulated in serum of MS patients, and this up-regulation was not influenced by age, gender, EDSS or medication status, but the elevated level of IL-33 was more pronounced in patients who responded to medication.
The relation ship between Syria and Lebanon is a distinguished one
because of the cultural social geographic and historical common factors. So
that, Syria considers that Lebanon has a stratieyical depth for it, especially its
conflict with (Israel) does end and parts of its lands still under the occupation
of the Zionist thus, any conflict in Lebanon between parties and ethnics
groups could be considered an important influence on the bases of the Syrian
policy. Moreover the issue of Palestine which is considered the central issue
for Syria and Arab as whole. In addition to some of the political movements
that happened in the region itself. It could be said that Syrian interference in
Lebanon has a positive infl
Developed technologies and complementary means for viewing theater through the ages, and they affected would improve and get better. Valsinogravea appeared to express a description and identification of existing in the theatrical space of lighting and decorative structure architecture, and the lighting of the elements that have contributed since ancient times in the process of the show, and played a significant role in strengthening the relationship between the recipient and actor and presentation theater as a whole scenes, working to broadcast a dramatic speech theatrical holds ideas and content and symbols and semantics affect the spectator of different age, particularly the child viewer, that little spectator who represent the
... Show MoreThe significance of interpretation for linguists varied , and its methods varied between appreciations, deletion, understanding the meaning
مشكلة البحث واهميته:-
اخذ موضوع العولمة قدراً وافياً من الاهتمام سواء على المستوى الاكاديمي او على مستوى اجهزة الاعلام والرأي العام ومختلف التيارات السياسية والاقتصادية والاجتماعية ، فلا يخلو أي لقاء اقتصادي او سياسي او اجتماعي من الحديث عن العولمة اذ نشرت العديد من الابحاث والدراسات وعقدت الكثير من الندوات والمؤتمرات لدراسة العولمة وبيان اثارها ولعل ذل
... Show MoreThere was an ancient Myth came from cuneiform texts which had written by ancient Iraqi , its hero is the goddess Nerottaa .it was appeared in two languages Sumerian and Akkadian .
The mihrab is an architectural element created by the Muslims for the necessities of which the direction of Qibla is set in the mosques, and the front stands in it during the prayer so as to provide a complete description of the Muslims inside the chapel. The mihrab has a third benefit in amplifying the voice during the time of prayer, Peace be upon him) and the Mosque of Damascus, the Mosque of Kairouan, and the Mosque of Amr Balfstat?.
ملخص البحث
العولمة ظاهرة اقتصادية سياسية اجتماعية لها انعكاساتها المختلفة على المجتمعات وعلى منظمات الأعمال في مختلف دول العالم، هذه الظاهرة أدت إلى المزيد من النتائج التي زادت منظمات الأعمال في الدول الغنية غناً وزادت منظمات الأعمال في دول العالم الثالث فقر، وقد ترتب على ذلك نتائج ايجابية لدى المجتمعات الغربية والمؤتلفة معها بسبب سيطرة منظمات الأعمال في تلك الدول على الأسواق في البلدان الن
... Show MoreThe essential objective of this study presents a analyzes of the combination of reality and fantasy in three dramas of Spanish author Alejandro Casona. "Trees die standing" (premiered in Buenos Aires in 1949), “Prohibited suicide in spring” (premiered in Mexico in 1937) and "The boat without fisherman" (premiered in Buenos Aires in 1945).
The first part is an introduction about the biography of Spanish author Alejandro Casona that will allow us to understand some peculiarities of his work in relation to the social historical context of his time.
In the second part of this study we have analyzed elements of reality and fantasy in the th
... Show Moreالسياسة في الفلسفة الاسلامية : الفكر السياسي عند الفارابي
التجليات الاقتصادية والثقافية والاعلامية للعولمة في العالم الثالث