The main purpose of this investigation is to evaluate the concentrations of six essential metals (Na⁺, Mg²⁺, K⁺, Ca²⁺, Fe²⁺ and Zn²⁺) in saffron and a farm soil using the neutron activation analysis (NAA) as a nuclear spectrometry method. The stratified random sampling method was used here. The NAA results showed the well uptake of Mg²⁺, K⁺, Ca²⁺, Fe²⁺, and Zn²⁺ in saffron, which is lower than the toxicity range. Based on the contamination factor and geoaccumulation index, soil contamination levels were determined uncontaminated by Zn, moderately contaminated by Na⁺ and Fe²⁺, and strongly contaminated by Ca²⁺, K⁺, and Mg²⁺. Results of the contamination degree and pollution load index indicated moderately/strongly soil contamination and a moderate geometric mean of the contamination index. The Na⁺ enrichment factor (EF) showed a minimal man-made impact on sodium enrichment. Saffron cultivation has likely caused more accumulations of Mg²⁺, K⁺, Ca²⁺, and Fe²⁺, as well as a considerable deficiency of Zn²⁺ in the soil, based on EFs. The biological concentration factor showed a significant zinc accumulation by the corm of saffron. There was well translocation from corm to all the aerial tissues for K⁺. Also, sodium adsorption ratio, exchangeable sodium percentage, pH, and electrical conductivity evaluated the non-salinity level of soil in all saffron farms.