The purified frog skin peptides were tested on leukemic patients lymphocytes, which revealed effects of cytotoxicity. Four frogs (Rana ridibunda) were stimulated by single intra-peritoneal injection of norepinephrine-HCl . Five different peptides;1(18) A, 2(19) L, 3(20) I,4(21) E and 5(22) Y were isolated and quantified. The peptide 3(20)I had 5.87% of hemolysis, while healthy human lymphocytes cytotoxic activity was for 2(19)L with inhibition( -10.4%).All peptides were subjected to polyacrylamide gel electrophoresis. The results revealed peptides 1(18)A, 2(19)L, 3(20)I which appeared as low as 10 KDa marker. Theoretically, the whole polypeptide had a molecular weight 7488.61 Dalton and contained on 62.405 amino acid (a.a). The peptide 4(21)E had a highest inhibitory effect(46%) on tumor cell line L20B. Furthermore , peptides effects on acute and chronic myeloid lymphocytic leukemia patients cell cultures revealed peptides selectivity in their action according to their net charge and functional group as reactant proton donor by the evidence of peptide 5(22)Y, 16.22 Dalton so it was either N—terminus (--NH2) or C—terminus (--OH) that led to cross cell membrane then acted as antigen mediated and activated cells in a high significant value (-142.37± 47.69)for acute myeloid lymphocytic leukemia .Both of peptides 3(20) I and 2(19) L were revealed a highly significant differences within Chr.40 and Chr. 22 of inhibition effects by testing volumes 15 µl and 10 µl . Those inhibition effects were due to peptides reaction with mitochondrial membrane which led to apoptosis . Conclusion; Frog skin peptides have a therapeutically worth for malignant diseases. Also some of peptides were activated lymphocytes may to cure immunodeficiency.
It was the sayings of Andalusia scholars in agriculture based on experiments and theories that helped a lot in the success and development of agriculture in the Andalusia ,and also The divisions of the soil and out types and forms it helped a lot of to know arable of non-arable land earth and all off the determination of the color of repentance is important often discovered by agricultural scientists and that helped in the cultivation of certain crops in certain land without another land.and though each particular agricultural crops specific soil in which to live and not live in other soil
The research demonstrates new species of the games by applying separation axioms via sets, where the relationships between the various species that were specified and the strategy of winning and losing to any one of the players, and their relationship with the concepts of separation axioms via sets have been studied.
ان ترجمة الافعال التي تصف احداث جارية وقت لحظة التكلم او في حالة استمرارية تفصح عن اختلافًا جذريا بين الإسبانية والعربية بسبب طبيعة الأفعال التي تصف هذه الأحداث، منها تعقيد بعض الصيغ، خاصة باللغة العربية، وعدم التكافؤ النحوي بين اللغتين في الكثير من البنى اللغوية. بهذا المعنى ، نجد أنه في اللغة العربية ، تتم صياغة هذه الظواهر اللغوية عن طريق أفعال تسمى الأفعال الناقصة التي تختلف طبيعتها ووظيفتها داخل الجملة
... Show MoreThe study aims to identify the neurological perfectionism of talented girls with disabilities and do a case study for one of these girls. The sample of the study consisted of (11) female students at the university level, 5 females with disability and (6) normal female-students. The sample also included (19) secondary school female students in Tabuk region, including 10 students with visual disability and (9) normal students. The case study was limited to one case of mentally superior girls (talented) with kinetic disability. The researcher adopted the descriptive methodology (case study), he used neurological perfectionism scale, Salah Mekhemar interview, Stanford interfacial intelligence scale fifth picture, case study form. The re
... Show Moreعرف العرب ، منذ القدم ، الأحجار الكريمة وعنوا بإقتناء أنواعا عديدة منها ، حيث كانت من أهم واردات سكان بلاد وادي الرافدين من السومريين والبابليين ثم الآشوريين ، كما عرفها المصريون القدماء وغيرهم من الشعوب القديمة ، فوجدت في قبورهم ومدافنهم وخزائن كنوزهم، مثل الياقوت الأحمر واللازورد واللؤلؤ . بالإضافة إلى ذلك فقد كان معدني الذهب والفضة من المعادن الوفيرة في هذه البلاد ، ولها الأولوية في صناعة الحلي.
يتناول هذا البحث موضوع (( فعل الامر في صيغة المبني للمجهول في اللغة الاكدية )) وهو يتعلق بقواعد اللغة الاكدية , وقد تضمن هذا البحث مقدمة وشقين : صيغة المبني للمجهول وفعل الامر. اما ما يخص المقدمة فقد شملت تعريف الفعل وانقساماته حسب قوة احرفه , الجذر , المعنى , والفاعل , كما تضمنت المقدمة أيضا الحديث عن الصيغ الفعلية الرئيسة الأربعة التي يتألف الفعل الاكدي منها إضافة الى الصيغ الثانوية التي تتضمنها الصيغ الرئيسة . و
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In 2020 one of the researchers in this paper, in his first research, tried to find out the Modified Weighted Pareto Distribution of Type I by using the Azzalini method for weighted distributions, which contain three parameters, two of them for scale while the third for shape.This research compared the distribution with two other distributions from the same family; the Standard Pareto Distribution of Type I and the Generalized Pareto Distribution by using the Maximum likelihood estimator which was derived by the researchers for Modified Weighted Pareto Distribution of Type I, then the Mont Carlo method was used–that is one of the simulation manners for generating random samples data in different sizes ( n= 10,30,50), and in di
... Show Moreأهمية البحث والحاجة اليه :
الحمد لله رب العالمين القائل (( وانك لعلى خلق عظيم )) (سورة القام :4) وصلى الله وسلم وبارك على نبينا محمد القائل " انما بعثت لأتمم مكارم الاخلاق " مسند احم: رقم الحديث 8595.
ان الاهتمام بالمشكلات السلوكية من اهم ركائن التربية والتعليم وتأتي تأتي اهميتها من ان التعيم يعين التغيير في سلوك الفرد نحو الافضل تحت تأثير الظروف والخبرات والمعارف والمهارات ال
... Show MoreThe energy consider generally and specifically the petroleum energy
from the prior requirement of the population and nations, and the basics of the
survival of mankind and all the challenges for the sake of continuum, so
without this energy the life of ankind being varied, so far the life is still as a
fact on the planet earth, and suppose the life may continue as the willing of
Allah ,that the events and the standards and the degree of development is still
as it is, in another word no any technical developments and no any
entertainment no transportation and also there is no demographic domination
for the whole lands belonging to Allah, certainly no way to talk more on what
we and the others knew, what is the g
The most prominant goal aimed at by contemporary islamic ideology is to present Islam to the whole world as a message of God that establishes for man a supreme civilization to accomplish justice, peace, development and prosperity
This mission is hindered by many obstacles that create Islamic ideology crisis such as loss of Comprehensive unifying vision which led to the loss of correct vision. This resulted in a Weakness of Priority arrangement and national interests a accomplishment.
There is also a problem of the curriculum that teaches Islamic ideology .
Another problem is that of the concept taken from Islamic culture.
Also another Problem Is the lack of understanding of
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