Background: Frovatriptan succinate (FVT) is an effective medication used to treat migraines; however, available oral formulations suffer from low permeability; accordingly, several formulations of FVT were prepared. Objective: Prepare, optimize, and evaluate FVT-BE formulation to develop enhanced intranasal binary nano-ethosome gel. Methods: Binary ethosomes were prepared using different concentrations of phospholipid PLH90, ethanol, propylene glycol, and cholesterol by thin film hydration and characterized by particle size, zeta potential, and entrapment efficiency. Furthermore, in-vitro, in-vivo, ex-vivo, pharmacokinetics, and histopathological studies were done. Results: Regarding FVT-loaded BE, formula (F9) demonstrated the best paramet

In the present work, the surface properties of mixed binary surfactants containing sodium dodecylbenzene sulfate (SDBS) and Tween 80 (TW80) surfactants in aqueous solutions were studied at temperature 293 K using surface tension measurements. The critical micelle concentration (cmc) magnitude for both individual surfactants and their mixtures were established the obtained results revealed  that the magnitude of cmc of the mixtures are less than the magnitude of individual surfactants and decrease with the increase in Tween 80 percent in solution which indicate the nonideal  mixing of the two surfactants. The values of molecular interaction parameters  and the mole fraction of surfactants in the micelle (X1) were calculated

The neutron, proton, and matter densities of the ground state of the proton-rich ²³Al and ²⁷P exotic nuclei were analyzed using the binary cluster model (BCM). Two density parameterizations were used in BCM calculations namely; Gaussian (GS) and harmonic oscillator (HO) parameterizations. According to the calculated results, it found that the BCM gives a good description of the nuclear structure for above proton-rich exotic nuclei. The elastic form factors of the unstable ²³Al and ²⁷P exotic nuclei and those of their stable isotopes ²⁷Al and ³¹P are studied by the plane-wave Born approximation. The main difference between the elastic form factors of unstable nuclei and the

Digital image started to including in various fields like, physics science, computer science, engineering science, chemistry science, biology science and medication science, to get from it some important information. But any images acquired by optical or electronic means is likely to be degraded by the sensing environment. In this paper, we will study and derive Iterative Tikhonov-Miller filter and Wiener filter by using criterion function. Then use the filters to restore the degraded image and show the Iterative Tikhonov-Miller filter has better performance when increasing the number of iteration To a certain limit then, the performs will be decrease. The performance of Iterative Tikhonov-Miller filter has better performance for less de

In this paper we investigate the use of two types of local search methods (LSM), the Simulated Annealing (SA) and Particle Swarm Optimization (PSO), to solve the problems ( ) and . The results of the two LSMs are compared with the Branch and Bound method and good heuristic methods. This work shows the good performance of SA and PSO compared with the exact and heuristic methods in terms of best solutions and CPU time.

   Cyberbullying is one of the major electronic problems, and it is not a new phenomenon. It was present in the traditional form before the emergence of social networks, and cyberbullying has many consequences, including emotional and physiological states such as depression and anxiety. Given the prevalence of this phenomenon and the importance of the topic in society and its negative impact on all age groups, especially adolescents, this work aims to build a model that detects cyberbullying in the comments on social media (Twitter) written in the Arabic language using Extreme Gradient Boosting (XGBoost) and Random Forest methods in building the models. After a series of pre-processing, we found that the accuracy of classification of t

This search that addressed with (( The Impact of Cultural Dimensions in multicultural Project Teams )) tagged is important variables in the project environment that rare has been adverted in Arabic studies .  The search problem is reflected in missing of awareness towards a cultural dimensions of the Diyala bridge area project team and their impact in project communications ، as well as weak project management interest in adopting a clear and scientific approach in the management and organization of project communications in order to reach the objective of the study ، was used questionnaire that built depending on previous global studies and has been adapted to accommodate Iraqi business e

Abstract  

  In this work, two algorithms of Metaheuristic algorithms were hybridized. The first is Invasive Weed Optimization algorithm (IWO) it is a numerical stochastic optimization algorithm and the second is Whale Optimization Algorithm (WOA) it is an algorithm based on the intelligence of swarms and community intelligence. Invasive Weed Optimization Algorithm (IWO) is an algorithm inspired by nature and specifically from the colonizing weeds behavior of weeds, first proposed in 2006 by Mehrabian and Lucas. Due to their strength and adaptability, weeds pose a serious threat to cultivated plants, making them a threat to the cultivation process. The behavior of these weeds has been simulated and used in Invas