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Formulation and Evaluation of Optimized Zaltoprofen Lyophilized Tablets by Zydis Technique

“Orodispersible Tablet” a tablet that is to be placed in oral cavity where it disperses rapidly by saliva with no need for water before swallowing. Zaltoprofen (ZLP) is one of NSAIDs which is used in the treatment of rheumatoid arthritis and osteoarthritis as well as to relieve inflammation and pain after surgery, injury and tooth extraction. The present study was aimed to prepare rapidly dissolved lyophilized Zaltoprofen tablet with different pharmaceutical excipients and studying the factors affecting pharmaceutical properties like (solubility, disintegration time DT, dissolution, etc.) of tablets. The lyophilized disintegrating tablets (LDTs) were prepared using Zydis technique by lyophilization an aqueous dispersion of Zaltoprofen with a matrix forming agent, gelatin, and a collapse protectant, glycine. In addition to many excipients like PVPK30 was used to improve the in vitro, in vivo disintegration time and dissolution rate, mannitol as bulk forming agent. Fourteen formulations were prepared to inspect the variables that affect the disintegration time and dissolution rate.  All the formulations were evaluated for their physical appearance, mechanical strength, X-ray diffraction, FTIR, DT, and in vitro drug release. The prepared tablets were optimized and formula was subjected to different measured parameters such as disintegration time, Drug content, and in-vitro drug release. Results obtained from dissolution studies and DT showed that lyophilized disintegrating tablets (LDTs) (F8,F10,F12,F13 was 45,37,21 and 17 Sec.) respectively ,while(F14) displayed considerably faster in vitro dissolution rate of (Zaltoprofen) 3 min. and DT 9 sec. The (lyophilized disintegrating tablets) were also evaluated showing the transformation into amorphous state and absence of interaction of Zaltoprofen with the components of the tablets. From visual inspection ,physical strength ,DT and release behavior obtained ,one can conclude that the formulas(F14) which contains Zaltoprofen 3.2% ,gelatin3%, mannitol 3%, glycine 1.5%, PVP K30 1.5% was the most suitable one.

Keywords : Zaltoprofen, lyophilization, PVPK30 .

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Publication Date
Sun Jan 30 2022
Journal Name
Iraqi Journal Of Science
Enhancement of Digital Stereo Vision Images based on Histogram and Gamma Correction Strategy

     Image contrast enhancement methods have been a topic of interest in digital image processing for various applications like satellite imaging, recognition, medical imaging, and stereo vision. This paper studies the technique for image enhancement utilizing Adaptive Histogram Equalization and Weighted Gamma Correction to cater radiometric condition and illumination variations of stereo image pairs. In the proposed method, the stereo pair images are segmented together with weighted distribution into sub-histograms supported with Histogram Equalization (HE) mapping or gamma correction and guided filtering.  The experimental result shows the experimented techniques outperform compare with the original image in ev

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Publication Date
Mon Mar 08 2021
Journal Name
Baghdad Science Journal
Stability constant measurements of thorivm (lv) and uranyle ions with some amino acids

ne,؛Stability constants were determined for complexes of amino acids : L-leuc tryptophane and Aspartic acid with thorium (IV ) and uranyle ( U02++) ions at ؛ serine

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Publication Date
Thu Jul 25 2019
Journal Name
Journal Of Plant Protection Research
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Publication Date
Tue Mar 14 2023
Journal Name
Iraqi Journal Of Science
Synthesis of gold nanoparticles using ceftriaxone sodium as a reducing and stabilizing agent

The synthesis of gold nanoparticles AuNPs was achievedby the reduction of sodium tetrachloroaurate (III) (NaAuCl4) with ceftriaxone sodium (CR) in aqueous solutionswithout the use of other reducing agent. The effect of reactants concentration, temperature and pH on the sizes and morphology of AuNPs were also studied. The synthesized AuNPs were characterized by UV- visible spectroscopy, X-ray diffraction (XRD), scanning electron microscope (SEM), and atomic force microscope (AFM) analysis. Conjugation of antibiotic with the nanoparticles was characterized by FTIR spectrophotometry.

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Publication Date
Thu Mar 30 2017
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Isolation of Some Microorganisms from Bar Soaps and Liquid Soaps in Hospital Environments

This study was designed to determine the colonization of the in-use hand washing soaps in hospital settings. It is a comparative cross-sectional research in a surgical specialties and Baghdad teaching hospital in Baghdad, Iraq. Swabs from surfaces of bar soaps and from liquid soaps via their applicator tips; at the sinks of toilets of hospital staff and working rooms of the wards were taken in January 2008. Conventional microbiologic methods were used for culture of the swabs and identification of the isolates. Colonization was detected 60% and 15.9% in bars and liquid forms respectively. And this lead to the conclusion that bar soaps could be colonized with microorganisms excessively. Liquid hand washing soaps are more appropriate in ho

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Publication Date
Mon Sep 25 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Structural and Optical properties of Polymers(PVA / PVP ) doped with V2O5 composites films

    Study the effect of doping V2O5 on polymers poly vinyl alcohol ( PVA), poly vinyl pyrrolidone (PVP) on the optical and structural properties for film prepared by using Casting method at thickness( 300±20)nm ,All the materials dissolved in distilled water  by magnetic mixer for one hour .The optical parameters measured by using UV-VIS spectrometer ,and the structural parameters measured by X-ray diffraction .when measured the energy gap found that the value was decreases from 4.6 eV to 2.98 eV with doping .The refractive index ,extinction coefficient ,absorption coefficient ,real and imaginary dielectric constants of (PVA/PVP) are increasing with doping by V2O5 and wit

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Publication Date
Thu Nov 21 2019
Journal Name
Al-kindy College Medical Journal
Investigate The Different Effect Of Nicotine On H460 And H441 Lung Cells Viability

Background: Nicotine is the foremost chemical constituent responsible for addiction in tobacco products, in the non-ionized condition can be easily absorbed via epithelial tissue of the lung, the mouth, the nose  and across the skin

Objective:The study examines the harmful effect of   the nicotine which is an important component of cigarette in vitro.

Type of the study: Cross-sectional study.

Methods: Examines the harmful effect of   the nicotine which is an important component of cigarette in vitro by using two types of lung cancer cell lines (H460 TP53+/+, H441 TP53-/-).

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Publication Date
Sat Dec 30 2023
Journal Name
Iraqi Journal Of Science
On-Site Disposal and Burial of Pit Wastes (Two Southern Iraqi Oil Fields)

On-site pit is the most common option that may be used to dispose drilling wastes. The contents of these pits vary, depending on the lithology of formations drilled and the drilling mud ,and different chemical additives.
Eighty samples of mud (sludge) and eighty samples of water have been collected from ten pits of two Iraqi oilfields(North Rumaila and South Rumaila/southern Iraq) and were chemically analyzed for metals Cr, Pb,As, Zn, Fe, Mn,K , Na,Ba, Ca, Mg,SO4=,and Cl- in order to determine the quality and quantity content of studied reserve pits
Inefficient equipment, using toxic materials for various drilling processes, absence of regulations for the design and monitoring of pit during and after drilling operation, and leaking

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Publication Date
Sat Dec 31 2022
Journal Name
Al-kindy College Medical Journal
The Association between CRP Levels with Comorbidities, Species, and Complications of Severe Malaria

Background: Malaria remains a leading cause of mortality in sub-Saharan Africa (including Sudan). C-reactive protein (CRP) is useful as   a marker of severity in malaria. African studies have shown that serum CRP levels correlate with parasite burden and complications in malaria, especially falciparum. However, there are no data on CRP levels in Sudanese malaria patients.

This study aims to evaluate the association between CRP levels with comorbidities, species, and complications of severe malaria

Subjects and Methods: A cross-sectional study enrolled 65 severe malaria patients at Khartoum state hospitals during the period from April to June2021. Manifestations of severe

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Publication Date
Mon Aug 01 2016
Journal Name
Journal Of Economics And Administrative Sciences
Social responsibility and obstacles application (Comparative research departments in the Municipality of Baghdad)

Abstract

The research aims to identify the extent of the practice of social responsibility in accordance with the social dimension and diagnosis of constraints applied.

Find the problem represented by the Social Responsibility and obstacles facing application in Baghdad Municipality through their workers trends analysis.

The adoption of the statistical method to analyze the data and information gathering, and selected municipalities of Adhamiya and Kadhimiya deliberate manner applied as a state and municipal councils of both cities as representatives of the local community to be the subject of research and comparison between them to see the reality of soci

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