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Phosphodiester Conjugation of Metronidazole and Dexamethasone as Possible Mutual Prodrug
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As possible mutual prodrug had been synthesized that contain metronidazole and dexamethazone conjugated through phosphodiester linkage. The rationale for this type of conjugate is to get a prodrug with possible site – specific delivery of its active constituents into the lower parts of the G.I.T.

This compound was synthesized by the reaction of dexamethzone – 21 – phosphate with metronidazole to form:(1 – (dexamethazone – 21 – phosphoryl) – metronidazole)

   This conjugate was performed using dicyclohexylcarbodiimide (DCC) as a condensing agent. The identity of the prepared compound had been confirmed using T.L.C., U.V. spectroscopy, IR spectroscopy and elemental analysis.

The partition coefficient for it had also been determined through n – Octanol / water partitioning system.

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Publication Date
Tue Sep 10 2019
Journal Name
Periodicals Of Engineering And Natural Sciences (pen)
A classification model on tumor cancer disease based mutual information and firefly algorithm
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Publication Date
Mon May 08 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Some Physiological Changes of Metronidazole Used to Treat Giardia lamblia in Human
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The study aimed to introduce the effect of Giardia lamblia infection on changes in
some biochemical parameters in serum of infected patients before and after treatment during a
period of one year, (from Feb, 2008 to Jan, 2009).
Samples of 50 infected patients who referred to Al-Kadimiyah Teaching Hospital,
were collected before and after 7 days of treatment.
The activity of liver enzymes (Gpt and Got) before treatment increased significantly as
it reached up to (8.47) u/L and 19.06 u/L, comparing with control values (6.455) u/L and
(8.39) u/L respectively. The activity of the enzymes decreased after treatment but the values
of Gpt and Got remained higher than the control values as reached 7-27 u/L, 11-64 u/L

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Publication Date
Sun Oct 03 2010
Journal Name
Journal Of The Faculty Of Medicine Baghdad
The possible association between Chlamydia pneumoniae infection and asthma.
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Background: Many etiological factors have been implicated in the pathogenesis of Asthma like; viruses, bacteria and Chlamydia pneumoniae. This study focuses on the role of Chlamydia
pneumoniae in asthma pathogenesis.
Patients and Methods: The detection of Anti-Chlamydia pneumoniae antibodies IgA, IgM and IgG in patients by ELISA, for 35 patients, 18 asthmatic patients, 12 patients with chest infection with no history of asthma, and 5 apparently healthy as control subjects.
Results: The results showed that 80% and 70% of the patients were negative for anti- Chlamydia pneumonia antibodies IgA and IgM respectively, while significantly (p<0.05) high number (73%) of patients were positive for IgG, of which

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Publication Date
Tue Jan 02 2018
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Cervical ripening by using extra-amniotic dexamethasone infusion versus extra-amniotic saline infusion
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Background: Induction of labour is a commonly practiced obstetric intervention designed to artificially initiate the process of cervical effacement to achieve vaginal delivery.
Objective: examine the hypothesis that corticosteroids, when administered extra-amniotically, can enhance labor process and reduce the induction--delivery interval in comparison with folly's and extra-amniotic saline infusion.
Patients and methods: This, randomized case- control study was conducted on99 women, who were referred to the AL-Batool teaching Hospital in Diyala, Iraq, for induction of labor with a Bishop score of less than or equal to 5 from January 2014-March 2016, and divided into 2 groups, 1st group consist of 58 pregnant, a 26F catheter &

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Publication Date
Wed Mar 29 2017
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Serum Level Profile and Pharmacokinetic Parameters of Single Oral Dose of Metronidazole in Type II Diabetic Patients
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Many pathophysiological processes can affect the pharmacokinetic properties of drugs in people with diabetes. The present study was deigned to evaluate the influence of diabetes mellitus (DM) on the pharmacokinetic parameters of metronidazole administered as single oral dose. Twelve healthy volunteers and twelve diabetic patients were enrolled in the present study. On day 1, a single oral dose of metronidazole 500 mg was administered orally to all participants at 9:00 am after a 10-hour fasting. Over the following 48 hours, blood samples were taken at frequent intervals and serum metronidazole concentrations were measured by a high-performance liquid chromatography method for assessment of pharmacokinetics of metronid

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Publication Date
Sat Jan 01 2011
Journal Name
Iraqi J Pharm Sci,
Serum Level Profile and Pharmacokinetic Parameters of Single Oral Dose of Metronidazole in Type II Diabetic Patients
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Many pathophysiological processes can affect the pharmacokinetic properties of drugs in people with diabetes. The present study was deigned to evaluate the influence of diabetes mellitus (DM) on the pharmacokinetic parameters of metronidazole administered as single oral dose. Twelve healthy volunteers and twelve diabetic patients were enrolled in the present study. On day 1, a single oral dose of metronidazole 500 mg was administered orally to all participants at 9:00 am after a 10-hour fasting. Over the following 48 hours, blood samples were taken at frequent intervals and serum metronidazole concentrations were measured by a high-performance liquid chromatography method for assessment of pharmacokinetics of metronidazole. The data

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Publication Date
Mon Jul 16 2018
Journal Name
Mathematics
Decomposition of Dynamical Signals into Jumps, Oscillatory Patterns, and Possible Outliers
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In this note, we present a component-wise algorithm combining several recent ideas from signal processing for simultaneous piecewise constants trend, seasonality, outliers, and noise decomposition of dynamical time series. Our approach is entirely based on convex optimisation, and our decomposition is guaranteed to be a global optimiser. We demonstrate the efficiency of the approach via simulations results and real data analysis.

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Publication Date
Mon Oct 28 2019
Journal Name
Journal Of Legal Sciences
International Commercial Arbitration and the Possible Application Thereof in Iraq
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 International commercial arbitration is a special judicial system based primarily on an agreement, be it an arbitration clause or an arbitration agreement (compromise), between

parties to a dispute. It is therefore a system aiming at settling commercial disputes by submitting them to a single arbitrator, or an arbitral panel, or an arbitral tribunal (e. g. , the

International Court of Arbitration). It is therefore also a means for settling an existing or future dispute that entails refraining from resorting to the competent judiciary. It is also

an extra – judicial action aiming at establishing justice between people. The aim of arbitration is to bring justice to parties in conflict, but it

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Publication Date
Sun Apr 02 2006
Journal Name
Journal Of The Faculty Of Medicine Baghdad
a study on trichomonas vaginalis and comparison between the efficacy of metronidazole and secnizole on women in Kirkuk province
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Background:

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Publication Date
Sun Oct 01 2023
Journal Name
Journal Of Medicine And Life
Evaluating the effect of ursodeoxycholic acid (UDCA) in comparison with dexamethasone and diclofenac in a rat model of rheumatoid arthritis
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