Preferred Language
Articles
/
bijps-615
Formulation and Clinical Evaluation of Orphenadrine citrate as a Plain Tablet
...Show More Authors

Orphenadrine is an anticholinergic ,antimuscarinic , centrally acting skeletal muscle relaxant .It presents in the form of citrate and HCl salts which are used in treatment of the symptoms of mild Parkinson's disease and also it is used as adjuvant with other drugs in the therapy .

      Many trials were made to formulate Orphenadrine citrate as a plain tablet using wet granulation or direct compression technique in order to get a satisfactory formula through studying the effect of various factors such as binders , diluents and disintegrants types .

    The best formula was obtained by using Poly Vinyl Pyrolidine (PVP) as a binder also the results indicated that starch and mannitol gave acceptable physical properties to the tablets when they were used as diluents . At the same time , the results showed that Avicel which was used as a disintegrant gave an acceptable disintegration and dissolution time in comparison with the reference tablet DISIPAL Ã’. In addition , the selected formula was used to study the effect of method of incorporation of disintegrant on the physical properties of tablets .It was found that the intragranular incorporation resulted in a shorter disintegration and dissolution times .The stability of Orphenadrine  citrate prepared tablets was also studied upon storage at 50°C, 60°C and 70°C for four months .The drug was fairly stable and the expiration date for the prepared tablet was considered to be equal for 5 years .On the other hand , the results of clinical study on patients suffering from Parkinson's disease indicated that patients with tremor (regular rhythmic oscillation of extremities especially hand and finger ) and mild symptoms of Parkinson's disease showed a good response to the prepared tablets , but it had no effect on patients of dystonia ( fixed upward gaze , neck twisting ,clenching jaws ) and akinesia ( slow down of movement of voluntary muscle and difficulty of initiation of movement ).

     The overall results of this study indicate that the drug can be prepared as tablets , which fit the requirements of British Pharmacopoeia since the prepared tablets gave satisfactory results .

Crossref
View Publication Preview PDF
Quick Preview PDF
Publication Date
Tue Nov 30 2021
Journal Name
Iraqi Journal Of Science
Clinical and Histopathological Study on Dog's Tumors in Iraq
...Show More Authors

The study was conducted on twenty dogs from variety breeds to estimate the
incidence of tumor mass and determine the risk factors of survey to cases of a year
in veterinary hospital in Baghdad. The most common clinical signs were, ulceration,
bleeding into lesions in addition to drowsiness, anorexia, fever and the others were
depended tumor's location in dog's body like lameness, lacrimation and bloody
constipation etc.
The results showed 70% of the infected dogs were working with military forces
and 30% of them were pet dogs and we found that the highest percentage of tumor
accrued in dogs aged more than 10 years and the females recorded 60% of infection.
Terrier breed had the highest percentage of infection (

... Show More
View Publication Preview PDF
Publication Date
Tue Oct 30 2018
Journal Name
Iraqi Journal Of Physics
Evaluation of radioactivity of cereals and legumes using a nuclear impact detector CN-85
...Show More Authors

The research aims to evaluate the radioactivity in elected samples of cereals and legume which are wide human consumption in Iraq using Nuclear Track Detectors (NTDs) model CN-85.
The samples were prepared scientifically according to references in this field. After 150 days of exposure, the detector were collected and chemically treated according to scientific sources (etching chemical), nuclear effects have been calculated using the optical microscope.
Radon (222Rn) concentration and uranium (238U) were calculated in unit Bq/m3 and (ppm), the results indicate that the highest concentration of radon and uranium was in yellow corn where the concentration of radon was 137.17×102 Bq/m3 and uranium concentration 2.63 (ppm). The lowest

... Show More
View Publication Preview PDF
Crossref (2)
Crossref
Publication Date
Fri Jun 30 2023
Journal Name
Iraqi Journal Of Science
Salivary Immune Parameters as A Predictor of Oral Diseases
...Show More Authors

Diabetes mellitus (DM) is a metabolic and hormonal disorder in which the body does not produce sufficient or respond ordinarily to insulin, leading to an increase in blood sugar (glucose) levels. This disordered has many side effects on body health, one of them being oral health. This study aimed to find these effects on several oral immune parameters included (IL6, CRP, and alpha-amylase) and the possible use of these parameters in the prediction of oral health and further risk sequel. A total of 91 specimens including 51 DM patients and 40 apparently healthy individuals were enrolled in this study which was carried out from November/2021 to February/2022. The results revealed that, abnormal increase of both IL6 and CRP in the saliva of

... Show More
View Publication Preview PDF
Scopus Crossref
Publication Date
Sun Mar 01 2015
Journal Name
Baghdad Science Journal
Terrestrial Invertebrates as a Bioindicators of Heavy Metals Pollution
...Show More Authors

Bioaccumulation of heavy metals in the terrestrial invertebrates in Al-Jadriyia district Baghdad- Iraq were investigated. Forth terrestrial invertebrates snails, slug, isopods, and diplopods , were selected for this study. The results showed that all invertebrate groups have the ability in accumulate considerable amounts of heavy metals. Higher levels of zinc and copper were observed in the isopods specimens, it's about ( 60.50±0.58 ) and ( 96.00±0.58 ) ppm respectively , while higher levels of lead were observed in the diplopods specimens ,it's about ( 23.00±1.15 ) ppm ,but the higher levels of both iron and cadmium were observed in snail specimens , it's about ( 590.00±1.15 ) and ( 9.50±1.15 ) ppm respectively .but the

... Show More
View Publication Preview PDF
Crossref
Publication Date
Tue Dec 01 2009
Journal Name
Iraqi Journal Of Physics
Spectrophotometrically Analysis of PMMA as a low – Doses Dosimeter
...Show More Authors

Polymethylmethacrylate film (PMMA) of thickness 75 μm was evaluated Spectrophotometrically for using it as a low-doses gamma radiation dosimeter. The doses were examined in the range 0.1 mrad-10 krad. Within an absorption band of 200-400 nm, the irradiated films showed an increase in the absorption intensity with increasing the absorbed doses. Calibration curves for the changes in the absorption differences were obtained at 218, 301, and 343 nm. At 218 nm the response for the absorbed doses is a linear in the range 10 mrad- 10 krad. Hence it is recommended to be adopted as an environmental low doses dosimeter

View Publication Preview PDF
Publication Date
Wed Aug 28 2024
Journal Name
World Academy Of Sciences Journal
Serum angiopoietin‑1 as a biomarker of missed miscarriage
...Show More Authors

View Publication
Scopus Crossref
Publication Date
Tue Jun 01 2010
Journal Name
Journal Of Economics And Administrative Sciences
Bayes Estimator as a Function of Some Classical Estimator
...Show More Authors

Maximum likelihood estimation method, uniformly minimum variance unbiased estimation method and minimum mean square error estimation, as classical estimation procedures, are frequently used for parameter estimation in statistics, which assuming the parameter is constant , while Bayes method assuming the parameter is random variable and hence the Bayes estimator is an estimator which minimize the Bayes risk for each value the random observable and for square error lose function the Bayes estimator is the posterior mean. It is well known that the Bayesian estimation is hardly used as a parameter estimation technique due to some difficulties to finding a prior distribution.

The interest of this paper is that

... Show More
View Publication Preview PDF
Crossref
Publication Date
Fri Jan 01 2021
Journal Name
Water Pollution And Management Practices
Existence of Antibiotics in Wastewater as a Pollution Indicator
...Show More Authors

View Publication
Scopus (2)
Crossref (3)
Scopus Crossref
Publication Date
Fri Aug 09 2024
Journal Name
Theory And Practice In Language Studies
Fallacy as a Strategy of Argumentation in Political Debates
...Show More Authors

This study aims to study argumentation in political debates by figuring out the logical fallacies employed in the debates of Clinton and Trump, the presidential nominees of the 2016 elections, and Biden and Trump, the leading contenders in the 2020 United States presidential election. The study attempts to answer the questions: (1) What relevance fallacies are adopted in the debate between Trump and Clinton? (2) What rhetorical devices are used to influence the audience and gain voters besides fallacies in the debates selected? The study analyses two texts from two arguments using Damer's (2009) taxonomy of relevance fallacy and rhetorical devices based on Perrine’s (1969) model of communication and interpersonal rhetoric to answe

... Show More
View Publication Preview PDF
Scopus Crossref
Publication Date
Thu Oct 24 2024
Journal Name
Scientific Reports
Effectiveness of high-frequency vibration, cotton rolls and elastomeric wafers in alleviating debonding pain of orthodontic metal brackets: a randomized clinical trial
...Show More Authors

View Publication
Crossref