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Concentration-Dependant Antioxidant Activity of Pentoxifylline in Nitrite-induced Hemoglobin Oxidation Model

         Free radical formation in heme proteins is recognized as a factor in mediating the toxicity of many chemicals. The present study was designed to evaluate the dose-response relationship of the free radical scavenging properties of pentoxifylline in nitrite-induced Hb oxidation. Different concentrations of pentoxifylline were added at different time intervals of Hb oxidation in erythrocytes lysate, and formation of methemoglobin (MetHb) was monitored spectrophotometrically. The results showed that in this model, pentoxifylline successfully attenuates Hb oxidation after challenge with sodium nitrite; this protective effect was found to be not related to the catalytic stage of Hb oxidation, though such effect was reported to be more prominent when the compound was at the same time of induction of Hb oxidation with nitrite. In conclusion, pentoxifylline can effectively, in concentration-dependent pattern, attenuate sodium nitrite-induced Hb oxidation in vitro.

Key words: pentoxifylline, radical scavenging, hemoglobin oxidation

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Publication Date
Sun Jun 12 2011
Journal Name
Baghdad Science Journal
Measurement of Uranium Concentration in Soil of Middle of Iraq using CR ?V 39 Track Detector

The aim of this research is to determine the uranium concentration in soil and water samples taken from different locations from the middle and south of Iraq using fission fragments track registration. Twelve samples of soil and water were taken from middle and South of Iraq. The nuclear reaction used as a source of nuclear fission fragments is U-235 (n.f) obtained by bombardment U-235with thermal neutrons from (Am-Be) neutron source with flux (5X103 n.cm-2.s-1). The concentration values were calculated by a comparison with standard samples recommended by IAEA.The results of the measurements show that the uranium concentration in soil samples were in Thekar (16.38 ppm), AL-Basra (16.1ppm) and (0.78 ppm) in Baghdad, from the results

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Publication Date
Wed Sep 27 2023
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Assessment of Serum Levels of Advanced Oxidation Protein Products in Type 2 Diabetic Patients with and without Retinopathy Taking Different Antidiabetic Treatments

The goal of this study was to investigate the protein peroxidation role by measuring serum levels of advanced oxidation protein products (AOPP) in type 2 diabetic patients with or without retinopathy and comparing them to controls to see if circulating AOPP levels can be used as a detection biomarker for DR. And see which of the two widely used antidiabetic treatment groups had the most impact on this oxidative stress marker. The groups were divided into two subgroups: 1) 70 type 2 diabetic patients (36 male, 34 female), 35 with diabetic retinopathy (DR) and 35 with no evidence of DR, and 2) non-diabetic controls (11 male, 9 female) were chosen from Ibn AL-Haitham Hospital for Ophthalmology and a Specialized Center for Endocrinology and Dia

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Publication Date
Sun Jul 03 2016
Journal Name
Journal Of The Faculty Of Medicine Baghdad
The association between hormonal variation, antioxidant status and oxidative stress in Iraqi women with endometriosis

Background: In the last years, Endometriosis affects up to 10 percent of reproductive aged Iraqi women. Little is known about the etiology of endometriosis in Iraqi women.
Objectives: The aim of this study is to investigate the hormonal changes, antioxidant status, Coenzyme Q10 and oxidative stress in women patients with endometriosis.
Patients and methods: 30 endometriotic women mean aged (31.16±5.61 year ) who were undergoing laparoscopy to participate in this study, and (n=30) healthy women volunteers mean aged (31.96±5.42 year) as control group.
Results: The results in this study revealed a highly significant increased (P<0.01) in estradiol (E2), uric acid (UA) and oxidative stress (MDA). The results of the Coenzyme Q10

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Publication Date
Fri Nov 24 2023
Journal Name
Iraqi Journal Of Science
The Investigation of Total Trihalomethanes Concentration in Drinking Water in Al-Dora and Al-Rasheed plants in Baghdad

During period from September 2012 to August 2013, concentration of total Trihalomethanes (TTHMs) was assessed in drinking water in Al-Dora and Al-Rasheed purification plants. 216 samples were collected from final basins of chlorination in purification plants and from sites that distributed among residential areas fed by the project. TTHMs concentration did not exceed (0.15 ppm) which is the maximum limits according to Iraqi standard specification for drinking water. The highest value was in July (0.12 ppm) and the lowest value was in November (0.01 ppm).

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Publication Date
Wed Nov 20 2024
Journal Name
Euphrates Journal Of Agricultural Science
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Publication Date
Wed Jun 08 2022
Journal Name
Applied Sciences
Effect of Adjuvant, Concentration and Water Type on the Droplet Size Characteristics in Agricultural Nozzles

One of the goals of adding adjuvants to agricultural spray solutions is to enhance the droplet size characteristics of this spray. Droplet size, in turn, has an influence in the deposited spray quality, in addition to the drift and losses of spray to off-target places. The aim of this research was to evaluate the effect of adding adjuvants to two types of water from different sources on the droplet size characteristics. Two types of adjuvants were employed in the tests: the active substance content of the first adjuvant was a 50% aqueous solution of sodium salt of alkylbenzenesulfonic acid—10% (HY), whereas the second was from rapeseed oil (natural origin)—85% (OL). Both adjuvants were tested in two concentrations: the first was

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Publication Date
Tue Jun 12 2007
Journal Name
Iraqi Journal Of Laser
Incident Laser Power and Concentration Effects on the Fluorescence of DCM Dye in PMMA Polymer

Incident laser power and concentration effects on fluorescence emission from DCM dye in PMMA polymer have been investigated. Different concentrations of the dye were used. It was found that the fluorescence intensity increased with increasing of the concentration of the dye, with a red shift. In addition, it was found that the fluorescence intensity increased with the increase of the incident laser power I0.

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Publication Date
Mon Aug 01 2011
Journal Name
Journal Of Engineering
Preservation of Required Chlorine Concentration in Baghdad Water Supply Networks using On-Site Chlorine Injection

The chlorine concentration variation in Baghdad water networks was studied. The
chlorine data were collected from Mayoralty of Baghdad and Ministry of Environment
(MOE) for the networks for both sides of the city Karkh and Rasafa for (2008-2009). The
study of these data indicates that there are no systematic testing program .Classified GIS
maps showed that the areas far from the treatment plants have almost always low
chlorine concentration .This indicates that the problem of the low chlorine concentration
in the far areas is due to cracks of pipe along the conveyance path ,as expected. The area's
most frequently have low concentration are Al-sadir,Al-Kadhimya, and Al-Amiria . It
was found also that the chlorine c

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Publication Date
Sun Feb 03 2019
Journal Name
Journal Of The College Of Education For Women
The Relationship between the age of the pregnant mother and the values hemoglobin blood and packed cell volume (PCV) in the Third Trimester for different age groups (descriptive study)

Pregnancy pose an additional burden on the body of the mother so as to meet their needs and the needs of the fetus and the body's need to iron increases excessively during pregnancy and iron is an essential element for the formation of hemoglobin blood Either hemoglobin is the key ingredient for red blood cells which carries oxygen to parts of the body, alas, most of the pregnant women begin their pregnancy inadequate stocks of iron in their bodies, which does not cover their need and requirement of the fetus, especially in the second and third trimesters of pregnancy When you reach the mother to the period in which they did not have the adequate amount of iron to produce hemoglobin become the mother was anemic So emerged the problem of

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Publication Date
Sat Sep 30 2023
Journal Name
Iraqi Journal Of Science
Investigating the Antioxidant and Apoptosis Inducing Effects of Biologically Synthesized Silver Nanoparticles Against Lymphoma Cells in Vitro

     The current study aimed to synthesize silver nanoparticles (Ag NPs) in a safe and eco-friendly biological method using green tea extract, characterize them using UV-vis spectroscopy, FTIR, XRD, FESEM, and AFM tools, then investigate their antioxidant potentials against DPPH and their cytotoxicity toward lymphoma cells using MTT and ethidium bromide/propidium iodide dual staining assays, and their genotoxic capacities by assessing their effects on the gene expression of p53, caspase3, bcl-2, and bax genes by qPCR and DNA fragmentation.  Results confirmed the synthesis of silver nanoparticles; the UV-vis results showed a peak of absorbance at 414 nm; FTIR analysis showed absorbance bel

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