Preferred Language
Articles
/
bijps-1827
Autophagy or Apoptosis: Anticancer Molecular Mechanism of Epigallocatechin Gallate with Natural Polyphenol Effect on HepG2 Cells Viability
...Show More Authors

Background: The anticancer impact of Epigallocatechin gallate (EGCG) the highly active polyphenol of green tea was abundantly studied.  Though, the exact mechanism of its cytotoxicity is still under investigation. Objectives: Hence, the current study designed to investigate the molecular target of EGCG in HepG2 cells on thirteen autophagy- and/or apoptosis- related genes. Methods: The apoptosis detection analyses such as flow cytometry and dual apoptosis assay were used. The genes expression profile was explored by the real-time quantitative-PCR. Results: EGCG increases G0/G1 cell cycle arrest and the real-time apoptosis markers proteins leading to stimulate apoptosis in 70% of the treated HepG2 cells. The up-regulation was recorded in two of autophagy inhibitory genes (FOS-1, FOS-2) and apoptosis inducer gene (DDIT3). While the other ten genes expressed down-regulation after treatment. The down regulation was manifested in the genes of mitochondrial autophagy marker proteins (BNIP3, BNIP3L, and NBR1), the autophagy regulator genes (BIRC5, MAPK9), and the gene that implicated in protein biosynthesis and protein modification (ITGB1). The genes that have pro-apoptotic function in cells (CAPNS1, CFLAR, EIF4G, and RB1) were also showed down-regulation after treatment. Conclusion: Thus, the results demonstrated a potential effect of EGCG to induce apoptosis rather than autophagy in the treated HepG2 cells that could play a good target for therapy. 

Scopus Crossref
View Publication Preview PDF
Quick Preview PDF
Publication Date
Mon Jan 01 2024
Journal Name
Fifth International Conference On Applied Sciences: Icas2023
Facial deepfake performance evaluation based on three detection tools: MTCNN, Dlib, and MediaPipe
...Show More Authors

View Publication
Scopus (1)
Crossref (1)
Scopus Crossref
Publication Date
Sun Dec 01 2002
Journal Name
Iraqi Journal Of Physics
Low-Rate High-Quality Parametric Audio Coder based on Sinusoidal plus Noise Representations
...Show More Authors

This paper presents a parametric audio compression scheme intended for scalable audio coding applications, and is particularly well suited for operation at low rates, in the vicinity of 5 to 32 Kbps. The model consists of two complementary components: Sines plus Noise (SN). The principal component of the system is an. overlap-add analysis-by-synthesis sinusoidal model based on conjugate matching pursuits. Perceptual information about human hearing is explicitly included into the model by psychoacoustically weighting the pursuit metric. Once analyzed, SN parameters are efficiently quantized and coded. Our informal listening tests demonstrated that our coder gave competitive performance to the-state-of-the- art HelixTM Producer Plus 9 from

... Show More
View Publication Preview PDF
Publication Date
Mon Jun 01 2020
Journal Name
Sensing And Bio-sensing Research
Hydrogen peroxide biosensor based on hemoglobin-modified gold nanoparticles–screen printed carbon electrode
...Show More Authors

View Publication
Scopus (38)
Crossref (30)
Scopus Clarivate Crossref
Publication Date
Fri Apr 23 2021
Journal Name
Al-nahrain Journal Of Science
A Clinical-Statistical Study on COVID-19 Cases in Iraq: A Case Study
...Show More Authors

Background: COVID-19 is a disease that started in Wuhan/China in late 2019 and continued through 2020 worldwide. Scientists worldwide continue to research to find vaccines, treatments, and medication for this disease. Studies also conenue to find the pathogenicity and epidemiology mechanisms. Materials and Methods: In this work, we analyzed cases obtained from Alshifaa center in Baghdad/Iraq for 23/2/2020-31/5/2020 with total instances of 797, positive cases of 393, and death cases of 30. Results: Results showed that the highest infection cases were among people aged between 41-45. Also, it was found that males' number of cases was more than females. In contrast, death cases were significantly higher in males than females. It was not

... Show More
View Publication
Scopus (2)
Crossref (3)
Scopus Crossref
Publication Date
Sat Jul 06 2024
Journal Name
Multimedia Tools And Applications
Text classification based on optimization feature selection methods: a review and future directions
...Show More Authors

A substantial portion of today’s multimedia data exists in the form of unstructured text. However, the unstructured nature of text poses a significant task in meeting users’ information requirements. Text classification (TC) has been extensively employed in text mining to facilitate multimedia data processing. However, accurately categorizing texts becomes challenging due to the increasing presence of non-informative features within the corpus. Several reviews on TC, encompassing various feature selection (FS) approaches to eliminate non-informative features, have been previously published. However, these reviews do not adequately cover the recently explored approaches to TC problem-solving utilizing FS, such as optimization techniques.

... Show More
View Publication Preview PDF
Scopus (2)
Crossref (4)
Scopus Crossref
Publication Date
Sat Jan 01 2022
Journal Name
Geminivirus : Detection, Diagnosis And Management
Geminiviruses occurrence in the middle east and their impact on agriculture in Iraq
...Show More Authors

View Publication
Scopus (17)
Crossref (1)
Scopus Crossref
Publication Date
Wed Apr 02 2025
Journal Name
Current Studies On Probability And Statistics
SAR-HDP: Non-parametric Topic Model for Aspect categorisation based on online reviews
...Show More Authors

Aspect categorisation and its utmost importance in the eld of Aspectbased Sentiment Analysis (ABSA) has encouraged researchers to improve topic model performance for modelling the aspects into categories. In general, a majority of its current methods implement parametric models requiring a pre-determined number of topics beforehand. However, this is not e ciently undertaken with unannotated text data as they lack any class label. Therefore, the current work presented a novel non-parametric model drawing a number of topics based on the semantic association present between opinion-targets (i.e., aspects) and their respective expressed sentiments. The model incorporated the Semantic Association Rules (SAR) into the Hierarchical Dirichlet Proce

... Show More
View Publication
Publication Date
Sun Jan 01 2023
Journal Name
Water, Air, & Soil Pollution
Sunflower Husks Coated with Copper Oxide Nanoparticles for Reactive Blue 49 and Reactive Red 195 Removals: Adsorption Mechanisms, Thermodynamic, Kinetic, and Isotherm Studies
...Show More Authors

View Publication
Publication Date
Sat Mar 01 2025
Journal Name
Radiology Case Reports
Intradural extra-medullary spinal cord tumor after dorso-lumbar spine fixation following 12th dorsal vertebra burst fracture: A case report with literature review
...Show More Authors

View Publication
Crossref
Publication Date
Sun Jan 01 2023
Journal Name
Water, Air, And Soil Pollution
Sunflower Husks Coated with Copper Oxide Nanoparticles for Reactive Blue 49 and Reactive Red 195 Removals: Adsorption Mechanisms, Thermodynamic, Kinetic, and Isotherm Studies
...Show More Authors

The adsorption process of reactive blue 49 (RB49) dye and reactive red 195 (RR195) dye from an aqueous solutions was explored using a novel adsorbent produced from the sunflower husks encapsulated with copper oxide nanoparticle (CSFH). Primarily, the features of a CSFH, such as surface morphology, functional groups, and structure, were characterized. It was determined that coating the sunflower husks with copper oxide nanoparticles greatly improved the surface and structural properties related to the adsorption capacity. The adsorption process was successful, with a removal efficiency of 97% for RB49 and 98% for RR195 under optimal operating conditions, contact time of 180 min, pH of 7, agitation speed of 150 rpm, initial dye concentration

... Show More
Crossref (19)
Crossref