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Role of Topical Ritodrine Hydrochloride in Experimentally Induced Hypertrophic Scar in Rabbits
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Hypertrophic scars are fibroproliferative illnesses caused by improper wound healing, during that, excessive inflammation, angiogenesis, and differentiated human dermal fibroblast (HDF ) function contribute to scarring, whereas hyperpigmentation negatively affects scar quality. Over 100 million patients heal with a scar every year. To investigate the role of the beta 2 adrenergic receptor (β2AR); Ritodrine, in wound scarring, the ability of beta 2 adrenergic receptor agonist (β2ARag) to alter HDF differentiation and function, wound inflammation, angiogenesis, and wound scarring was explored in HDFs, zebrafish, chick chorioallantoic membrane assay (CAM), and a porcine skin wound model, respectively. A study identify a β2AR-mediated mechanism for scar reduction. β2ARag significantly reduced HDF differentiation, via multiple cAMP and/or fibroblast growth factor 2 or basic FGF (FGF2)-dependent mechanisms, in the presence of transforming growth factor betaβ1, reduced contractile function, and inhibited mRNA expression of a number of profibrotic markers. β2ARag also reduced inflammation and angiogenesis in zebrafish and CAMs in vivo, respectively. In Red Duroc pig full-thickness wounds, β2ARag reduced both scar area and hyperpigmentation by almost 50% and significantly improved scar quality. Indeed, mechanisms delineated in vitro and in other in vivo models were evident in the β2ARag-treated porcine scars in vivo. Both macrophage infiltration and angiogenesis were initially decreased, whereas DF function was impaired in the β2ARag-treated porcine wound bed. This data reveal the potential of β2ARag to improve skin scarring.

The purpose of this study was to assess the therapeutic effect of topical Ritodrine hydrochloride on hypertrophic scars in rabbits.

Thirty-two healthy male albino rabbits that divided in to 4 groups were included in the study (healthy; induced untreated hypertrophic scars; induced hypertrophic scars treated with 0.1% Triamcinolone acetonide (TAC) as a standard drug; and induced hypertrophic scars treated with 0.5% Ritodrine HCL gel twice daily for 21 days. Histopathology of skin sections, transforming growth factor beta1 TGFβ-1 level, and collagen III alpha1 in skin tissue were all used as outcome measures.

Compared to the induced hypertrophic scar group; treatment with Ritodrine significantly reduced means of TGF β1 and collagen III (p ≤0.01); significantly reduce mean score of inflammation (p ≤0.001), significantly lowered scar size (P ≤ 0.001), and significantly lower mean scar height (P≤0.001), but no significant decrease in SEI (P>0.05).

Therapy of induced hypertrophic scar with topical Ritodrine was successfully effective in rabbits. It reduced the immunological score (TGF-β1, collagen III), inflammation, and scar size in a substantial way. This effect was comparable (except in terms of SEI) to topical Triamcinolone acetonide efficacy

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Publication Date
Wed Jun 01 2022
Journal Name
Journal Of King Saud University - Computer And Information Sciences
Heuristic initialization of PSO task scheduling algorithm in cloud computing
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Publication Date
Wed Mar 29 2023
Journal Name
Asian Journal Of Water, Environment And Pollution
Biosorption of Pollutants in Diyala River by Using Irrigated Vegetables
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In the absence of environmental regulation, food stays to be contaminated with heavy metals, which is becoming a big worry for human health. The present research focusses on the environmental and health effects of irrigating a number of crops grown in the soils surrounding the Al-Rustamia old plant using treated wastewater generated by the plant. The physicochemical properties, alkalinity, and electrical conductivity of the samples were evaluated, and vegetable samples were tested for Cd, Pb, Ni, and Zn, levels, and even the transfer factor (TF) from soils to crops and crop and multi-targeted risk, daily intake (DIM) of metals, and health risk index (HRI) was calculated. The findings found that the average contents of Zn, Pb, Ni, an

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Publication Date
Fri Jan 01 2016
Journal Name
Animal Nutrition And Feed Technology
Insect Meal as a Source of Protein in Animal Diet
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Publication Date
Wed Sep 27 2023
Journal Name
Icst Transactions On Scalable Information Systems
Tools and Process of Defect Detection in Automated Manufacturing Systems
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INTRODUCTION: A range of tools and technologies are at disposal for the purpose of defect detection. These include but are not limited to sensors, Statistical Process Control (SPC) software, Artificial Intelligence (AI) and machine learning (ML) algorithms, X-ray systems, ultrasound systems, and eddy current systems. OBJECTIVES: The determination of the suitable instrument or combination of instruments is contingent upon the precise production procedure and the category of flaw being identified. In certain cases, defects may necessitate real-time monitoring and analysis through the use of sensors and SPC software, whereas more comprehensive analysis may be required for other defects through the utilization of X-ray or ultrasound sy

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Publication Date
Sat Dec 30 2023
Journal Name
حوليات أداب عين شمس
Naturalism in Yitzhak Shami's A novella (Revenge of the ancestors)
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The doctrine of naturalism appeared in the sixties of the nineteenth century as a continuation of the realism tendency and an expression of feeling in historical and social conditions in the language known to societies in Western Europe. Naturalism is a literary doctrine with an artistic style derived from realism, but it carries with it a philosophical character. Thus, we can understand that naturalism is those external and social forces that impede human freedom, as opposed to the subconscious internal genetic forces that determine moral responsibility and human rationality, far from displaying aesthetic images, as it is closer to reality than imagination. Naturalism looks at several axes, the most important of which are mental and psycho

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Publication Date
Wed Sep 04 2019
Journal Name
American Association Of Pharmaceutical Scientists
Recent advances in polymeric implants
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Implantable drug delivery systems, such as drug pumps and polymeric drug depots, have emerged as means of providing predetermined drug release profiles at the desired site of action. While initial implants aimed at providing an enduring drug supply, developments in polymer chemistry and pharmaceutical technology and the growing need for refined drug delivery patterns have prompted the design of sophisticated drug delivery implants such as on-demand drug-eluting implants and personalized 3D printed implants. The types of cargo loaded into these implants range from small drug molecules to hormones and even therapeutic cells. This review will shed light upon recent advances in materials and composites used for polymeric implant fabrication, hi

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Publication Date
Sun Feb 03 2019
Journal Name
Journal Of The College Of Education For Women
Domestic Technique in Batik Art
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Domestic Technique in Batik Art

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Publication Date
Thu May 14 2020
Journal Name
Journal Of Planner And Development
Dialogue bridges in the city
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Since its establishment, cities have been looking for a special urban architectural language that distinguishes them from other cities and expresses their distinctive identity through continuous products through time and controls the totality of temporal and spatial changes through a bridging dialogue that manages the language of the city correctly, Which gives the stability of that language and its ability to adapt to the total changes that occur in the city over time, and thus the possibility of producing ideas integrated series and ideas are renewed overlapping with the legacy and bear multiple layers of meaning and signals and symbols create a total of two meanings The problem of research (not comprehensive studies to create a contem

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Publication Date
Tue Aug 15 2023
Journal Name
Al-academy
Digital collage in contemporary arts
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The research tagged (Digital Collage in Contemporary Art) consisted of four chapters. The first chapter was devoted to the methodological framework of the research. The problem ended with the following questions: How does digital collage represent contemporary art? What is the variable at the level of meaning shifts in composing works according to the digital collage? Was the digital collage a qualitative leap in the path of the aesthetic pattern in art? How does digital collage interfere with contemporary life and societies? It included the aim of the research and its importance, while the second chapter dealt with two topics, the first (reading in the concept of collage), and the second (digital collage). The third chapter was devoted

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Publication Date
Mon Dec 30 2019
Journal Name
College Of Islamic Sciences
Talk show in prophetic stories
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This research deals with dialogic submission as one of the most important deliberative topics in the process of linguistic communication between the two sides of the discourse, and therefore we find in this research its concept among the ancient Arabs of grammarians, rhetoric and fundamentalists, and we started with Western linguists as a result of their knowledge of the philosophy of language, and this research was satisfied with the principle of cooperation that came By Grace as the founder of this modern deliberative topic with an attempt to monitor this principle in the prophetic stories and the susceptibility of the stories to this kind of implicit communication, as the prophetic stories included multiple deliberative dimensions of

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