Preferred Language
Articles
/
bijps-1641
Role of Topical Ritodrine Hydrochloride in Experimentally Induced Hypertrophic Scar in Rabbits
...Show More Authors

Hypertrophic scars are fibroproliferative illnesses caused by improper wound healing, during that, excessive inflammation, angiogenesis, and differentiated human dermal fibroblast (HDF ) function contribute to scarring, whereas hyperpigmentation negatively affects scar quality. Over 100 million patients heal with a scar every year. To investigate the role of the beta 2 adrenergic receptor (β2AR); Ritodrine, in wound scarring, the ability of beta 2 adrenergic receptor agonist (β2ARag) to alter HDF differentiation and function, wound inflammation, angiogenesis, and wound scarring was explored in HDFs, zebrafish, chick chorioallantoic membrane assay (CAM), and a porcine skin wound model, respectively. A study identify a β2AR-mediated mechanism for scar reduction. β2ARag significantly reduced HDF differentiation, via multiple cAMP and/or fibroblast growth factor 2 or basic FGF (FGF2)-dependent mechanisms, in the presence of transforming growth factor betaβ1, reduced contractile function, and inhibited mRNA expression of a number of profibrotic markers. β2ARag also reduced inflammation and angiogenesis in zebrafish and CAMs in vivo, respectively. In Red Duroc pig full-thickness wounds, β2ARag reduced both scar area and hyperpigmentation by almost 50% and significantly improved scar quality. Indeed, mechanisms delineated in vitro and in other in vivo models were evident in the β2ARag-treated porcine scars in vivo. Both macrophage infiltration and angiogenesis were initially decreased, whereas DF function was impaired in the β2ARag-treated porcine wound bed. This data reveal the potential of β2ARag to improve skin scarring.

The purpose of this study was to assess the therapeutic effect of topical Ritodrine hydrochloride on hypertrophic scars in rabbits.

Thirty-two healthy male albino rabbits that divided in to 4 groups were included in the study (healthy; induced untreated hypertrophic scars; induced hypertrophic scars treated with 0.1% Triamcinolone acetonide (TAC) as a standard drug; and induced hypertrophic scars treated with 0.5% Ritodrine HCL gel twice daily for 21 days. Histopathology of skin sections, transforming growth factor beta1 TGFβ-1 level, and collagen III alpha1 in skin tissue were all used as outcome measures.

Compared to the induced hypertrophic scar group; treatment with Ritodrine significantly reduced means of TGF β1 and collagen III (p ≤0.01); significantly reduce mean score of inflammation (p ≤0.001), significantly lowered scar size (P ≤ 0.001), and significantly lower mean scar height (P≤0.001), but no significant decrease in SEI (P>0.05).

Therapy of induced hypertrophic scar with topical Ritodrine was successfully effective in rabbits. It reduced the immunological score (TGF-β1, collagen III), inflammation, and scar size in a substantial way. This effect was comparable (except in terms of SEI) to topical Triamcinolone acetonide efficacy

Scopus Crossref
View Publication Preview PDF
Quick Preview PDF
Publication Date
Wed Jan 04 2017
Journal Name
International Journal Of Science And Research (ij
Study of Histological Structure of Kidney in Snake Eryx gaculus gaculus
...Show More Authors

The purpose of this study was to examine the histological structure of the kidney in snake Eryx gaculus gaculus. In present study, the snakes were collected from the city of Baghdad and transferred to the laboratory where their kidneys were dissected out. The samples were then processed to be prepared for histological examination microscopial observations showed that there is no border between the cortex and medulla regions of kidney. The kidney consists of nephrons which are composed of glomerulus surrounded by Bowman’s capsule; the other segments are proximal tubule, distal tubule and connecting tubule. The epithelial tissue lining of these segments simple cuboidal tissue.

View Publication Preview PDF
Publication Date
Mon Jan 01 2018
Journal Name
Ultramicroscopy
Characterization of trapped charges distribution in terms of mirror plot curve
...Show More Authors

View Publication
Scopus (6)
Crossref (3)
Scopus Clarivate Crossref
Publication Date
Sun Apr 07 2013
Journal Name
Journal Of Educational And Psychological Researches
The effect of relaxation music in reducing symptoms of dental anxiety
...Show More Authors

Many behavioral researchers pointed out the importance of relaxation techniques in the treatment of different psychological disorders where find  the importance of these techniques in reducing anxiety and stress and the resulted of behaviors and habits, with the development of these techniques are being used to gain public health, whether mental health or physical or mentality, and one of these techniques is music therapy that reduces tension and anxiety and operates a state of relaxation, which is used in the treatment of  patients of dental clinic.                        

Re

... Show More
View Publication Preview PDF
Publication Date
Wed Dec 30 2015
Journal Name
College Of Islamic Sciences
Rhetoric of the ellipses   In the poetry of Namik Abdul Deeb
...Show More Authors

The research attempts to identify the pattern of punctuation in contemporary Iraqi poetry through delving into the poetry of an Iraqi poet belonging to the seventieth generation, Namik Abdul Deeb, who belongs to the poets of Arab modernity in general, the research has reached many results, including that the signs of deletion were vocabulary marks any They are located in the center of the poetic singular, or inline markers, which are those that fall within the poetic line of the prose poem separating its vocabulary, or cross-sectional marks located within the poetic passages that are part of the poetic text, and finally text marks which are located within the poetic text and fragmented into Parts. The research also found that the work of

... Show More
View Publication Preview PDF
Publication Date
Sat Jun 01 2013
Journal Name
Journal Of The College Of Languages (jcl)
Violation of the Strategies of Conversation in Some English Selected Plays
...Show More Authors

The present study analyzes the violation of the strategies of conversation in two English plays namely Richard II and King Lear. The present study tries to achieve the following goals: 1. showing how the strategies of real conversation can be applied to conversation in plays. 2. analyzing how the characters communicate with each other to discover how Shakespeare violates the strategies of conversation in depicting his characters. The study has been conducted on the bases of the following hypotheses:

  1. The strategies of conversation which are derived from the study of natural conversation can be applied to conversation in drama with some modification for dramatic purposes.

... Show More
View Publication Preview PDF
Publication Date
Wed Jan 01 2020
Journal Name
Route Educational And Social Science Journal
SURVIVAL IN TIMES OF PANDEMICS: THE PROPHETIC VISION OF JACK LONDON
...Show More Authors

View Publication
Publication Date
Sun Dec 02 2018
Journal Name
Journal Of The College Of Education For Women
The Level of Career Involvement of Primary School Managers in Baghdad
...Show More Authors

The study aimed to identify career engagement among school principals, the researcher used descriptive approach and reached the study sample (230) school, principals. The researcher instruments used: career engagement, has been checked and face validity, and construction and consistency of the instruments using internal consistency Cronbach's alpha The study came to the following findings: - The degree of career engagement among school principals was (29.0200) this refers to a higher level, compared with the theoretical average of (27) and the study showed that the results showed no significant statistical differences between school principals in the level of career engagement due to the variable sex.

View Publication Preview PDF
Publication Date
Sun Mar 06 2016
Journal Name
Baghdad Science Journal
Prevalence of Urinary Schistosomiasis in Al-Rusafah Regions of Baghdad governarate
...Show More Authors

Urinary Schistosomiasis is one of important diseases that cause irritation and damage of urinary tract and other systems and tissues and can not be expected by doctors when diagnosing urinary tract diseases.The current study is conducted to investigate the prevalence of schistosomiasisin Baghdad / Al-Rusafa. 191urine samples were collected fromresidents ofsome areas of Al-Rusafain Baghdad governarate (Almashtal, Albaladyat, Alameen, Baghdad aljadida and Alnahrawan) for the period from March until the end of September 2010.The samples were examined by the precipitation and examination of micro hematuria by reagent strips. The total infection percentage was 9.42% (18/191) and was significantly higher in males compared tofemales12.64% (11/87)

... Show More
View Publication Preview PDF
Crossref (1)
Crossref
Publication Date
Wed Mar 29 2023
Journal Name
Journal Of The College Of Education For Women
Geographical Analysis of Sanitation Workers in the Urban District of Kut
...Show More Authors

Cleaning is one of the services provided by the state and its ad hoc institutions. Every developed country is clean due to the good planning and attention given to the staff of all municipalities and service institutions. Beside, the attention paid to this sector is considered one of the windows to maintain the states’ aesthetics. If janirtos stop disposing of all the discarded wastes, the result will be having big piles of waste, affecting accordingly the health and safety of its citizens and the aesthetics of the areas. The janitors and those responsible for them are tha staff that the state must take care of because of their importance to the state in general and to the province in particular. The importance of the research

... Show More
View Publication Preview PDF
Crossref
Publication Date
Mon May 01 2017
Journal Name
2017 5th International Conference On Information And Communication Technology (icoic7)
Analysis of the number of ants in ant colony system algorithm
...Show More Authors

View Publication
Scopus (29)
Crossref (14)
Scopus Crossref