Preferred Language
Articles
/
bijps-1605
Evaluation of Hepatic Enzymes in major β-thalassemic Patients using Deferasirox
...Show More Authors

Abstract

β-thalassemia major is a genetic disease that causes sever defect in normal hemoglobin synthesis. The patients with β-thalassemia major need periodic blood transfusions that can result in accumulation of body iron, so treatment with iron chelating agent is required. Complications of this iron overload affecting many vital organs, including the liver. The aim of this work was to evaluate liver enzymes in β -thalassemia major patients with deferasirox versus without it. Two groups of β-thalassemia major patients were involved in this study named group A; 40 β-thalassemia patients of blood transfusion dependent without deferasirox, group B; 40 β-thalassemia patients of blood transfusion dependent on deferasirox. In addition to group C, 40 normal subjects as a control group. Samples of serum were obtained from all participants to be tested for alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase and ferritin. The biochemical data of the patients on blood transfusion without deferasirox showed significant increases in the mean serum levels of aminotransferases and ferritin in comparison with control. Whereas the patients on blood transfusion with deferasirox exhibit significant increases in the means serum levels of alkaline phosphatase activity and ferritin in comparison with control. Iron overload may cause liver injury, shown by significant increases of; ALT and AST activities and elevated ferritin level in serum of transfusion dependent patients of β-thalassemia major. Administration of deferasirox for β-thalassemia major patients causes elevation of serum ALP activity and ferritin level.

       

Scopus Crossref
View Publication Preview PDF
Quick Preview PDF
Publication Date
Wed Apr 02 2014
Journal Name
Iraqi Journal Of Physics
The evaluation of left ventricle stiffness index in patients suffering from hypertension
...Show More Authors

Many diseases can produce cardiac overload, of these disease hypertension, valve disease congenital anomaly in addition to many other disease. One of the most common diseases causing left ventricle overload is hypertension. A long term hypertension can cause myocardium hypertrophy leading to changes in the cardiac contractility and reduced efficiency. The investigations were carried out using conventional echocardiography techniques in addition to the tissue Doppler imaging (TDI) from which many noninvasive measurements can be readily obtained. The study has involved the effect of hypertension on the myocardium stiffness index through the measurement of early diastolic filling (E) and the early velocity of lateral mitral annulus (E

... Show More
Publication Date
Mon May 08 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Evaluation Of liver And Kidney Functions In Lung And Bladder Cancer Patients
...Show More Authors

This study was performed at Nuclear Radiation Hospital in Baghdad for the period from
January 2011 to May 2011. 44 Blood samples were collected from patients suffered lung and
bladder cancer and 24 samples as healthy control individuals.
Routine liver functions tests were studied by measuring S.GPT, S.GOT and Kidney
function was evaluated by estimation of blood urea and creatinine in serum samples of
individuals studied.
It was observed that the incidence of lung and bladder cancer was higher in males than
females patients ( male 81.82 %, 72.73%, female18 .18%, 27.27% respectively).
Insignificant difference was noted among age of lung and bladder cancer patients
compared with control group. The results

... Show More
View Publication Preview PDF
Publication Date
Mon Feb 18 2019
Journal Name
Iraqi Journal Of Physics
The evaluation of left ventricle stiffness index in patients suffering from hypertension
...Show More Authors

Many diseases can produce cardiac overload, of these disease hypertension, valve disease congenital anomaly in addition to many other disease. One of the most common diseases causing left ventricle overload is hypertension. A long term hypertension can cause myocardium hypertrophy leading to changes in the cardiac contractility and reduced efficiency. The investigations were carried out using conventional echocardiography techniques in addition to the tissue Doppler imaging (TDI) from which many noninvasive measurements can be readily obtained. The study has involved the effect of hypertension on the myocardium stiffness index through the measurement of early diastolic filling (E) and the early velocity of lateral mitral annulus (Ea

... Show More
View Publication Preview PDF
Crossref
Publication Date
Fri Oct 01 2010
Journal Name
Saudi Pharmaceutical Journal
Comparative clinical evaluation of ketotifen and montelukast sodium in asthmatic Iraqi patients
...Show More Authors

View Publication
Scopus (8)
Crossref (3)
Scopus Crossref
Publication Date
Mon Jul 01 2024
Journal Name
Indian Journal Of Clinical Biochemistry
Evaluation of Bone Turnover Markers in Patients with Acute and Chronic Leukemia
...Show More Authors

Scopus (1)
Scopus Clarivate Crossref
Publication Date
Wed Oct 01 2008
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Abdominal Operations without Nasogastric tube :A major advance in modern surgery
...Show More Authors

Background: Routine use of nasogastric tubes, after abdominal operations, is intended to hasten the return of bowel function, prevent pulmonary complications, diminish the risk of
anastomotic leakage, increase patient comfort and shorten hospital stay. Aim of this study is to evaluate the efficacy of routine nasogastric decompression after abdominal surgery, in
achieving each of the above goals.
Patients and methods:Two hundred and twelve patients having abdominal operations of any type, emergency and elective have been followed prospectively over a period of three years (1st December 2004 until end of December 2007) in Baghdad teaching hospital. Patients were randomized into two groups. Group 1 had naso

... Show More
View Publication Preview PDF
Crossref
Publication Date
Mon Nov 01 2021
Journal Name
Archives Of Razi Institute
Effect of Leishmania major infection on the expression of TGF beta in murine
...Show More Authors

Leishmania major is a protozoan parasite that causes cutaneous Leishmaniasis disease in human beings and animals. The disease is prevalent in tropical and semitropical countries and has great health importance. The present study aimed to identify the histological changes in the organs infected with L. major and to provide a sophisticated diagnostic method for infection through detecting TGF-β cytokine by immunohistochemistry technique(IHC) from October 2020 to January 2021. A total of 40 samples of paraffin blocks were used for different organs including skin, spleen, liver, kidney, and heart of male and female BALB/c mice, aged 6-8 weeks, which were previously infected subcutaneously with L. major promastigotes at a dose of 1×107 promast

... Show More
Preview PDF
Publication Date
Sat Sep 01 2018
Journal Name
Water Resources
Carcinogenic Risk Assessment of Trihalomethanes in Major Drinking Water Sources of Baghdad City
...Show More Authors

View Publication
Scopus (17)
Crossref (17)
Scopus Clarivate Crossref
Publication Date
Sun Sep 01 2013
Journal Name
Baghdad Science Journal
Induction of antioxidant enzymes in wheat (Triticum spp.) grown under salt stress
...Show More Authors

A pot culture experiment was conducted at the greenhouse of soil and water resources department in College of Agriculture, University of Baghdad in Abo-Ghraib at season 2009-2010 to investigate the effects of using foliar application of some macro and micronutrients in induce antioxidant enzymes in wheat grown under salt stress . Doar85 planted under three levels of salt stress, and three combinations of foliar application were used from nutrients (K+ Ca) at 3000 and 1500 mg.L-1 respectively, and (Fe + Zn + Mn) at 30, 20, and 10 mg.L-1 respectively , and ( K+ Ca) + (Fe+ Zn + Mn). The results showed that increasing levels of sodium chloride in the irrigation of water significantly increased at p<0.05 level SOD and POD activity

... Show More
View Publication Preview PDF
Crossref
Publication Date
Mon Mar 27 2017
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Evaluation of the Clinical use of Metformin or Pioglitazone in Combination with Meloxicam in Patients with Knee Osteoarthritis; using Knee Injury and Osteoarthritis outcome Score
...Show More Authors

Osteoarthritis is the most prevalent arthritic disease and a leading cause of disability. The pathogenesis of osteoarthritis involves multiple etiologies, including variable degree of synovial inflammation. Metformin and pioglitazone could potentially reduce the levels and activity of inflammatory mediators. This may consider as a new therapeutic approach added to the current used drugs in an attempt to decrease the pain, inflammation, and improve daily activity and quality of life in patients with knee osteoarthritis.

This study designed to evaluate the clinical utility of using metformin or pioglitazone as anti-inflammatory agents in combination with non-steroidal anti-inflammatory drugs (NSAID) of selective type of cyclooxygen

... Show More
View Publication Preview PDF
Crossref (4)
Crossref