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Solubility and Dissolution Rate Enhancement of Bilastine by Solid Dispersion Technique
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Bilastine (BLS) is non-sedating new-brand H1 antihistamine that has selective peripheral effects, the drug has a problem of an insufficient aqueous solubility and accordingly low dissolution rate, and low bioavailability. Solid dispersion (SD) is one of the most effective techniques for improving the solubility and the dissolution rate of poorly soluble drugs by the dispersion of drug within an inert hydrophilic carrier.   The aim of this study is to increase the solubility and dissolution rate of the BLS using SD technique. Twenty-nine BLS SD formulas were prepared using different carrier polymers include Pluronic 407 (Poloxamer407), Poloxamer188, Urea, Polyethylene glycol 6000 (PEG6000) and Polyvinylpyrrolidone (PVP K30) and employing two different preparation methods (solvent evaporation and kneading method) at different drug: polymer ratios (1:1 ,1:3,1:5,1:10,1:15). The prepared SD formulas were evaluated for their percent yield, drug content, aqueous solubility, dissolution rate, PXRD, and FTIR. The SD technique successfully improved the solubility and dissolution rate of BLS. The improvement was largely dependent on the polymer type and drug: polymer ratio. The solubility improvement using different polymers was in the following order: PVP K30> PLX188> PEG6000> Urea> PLX407. The solid dispersion formula that showed the best outcomes in terms of dissolution improvement was prepared using the solvent evaporation technique employing PVP K30 at ratio of drug: polymer of 1:15. The optimized formula showed 10.2 folds increment in the solubility compared to pure BLS. It can be concluded that the SD technique can successfully improve the solubility and dissolution rate by solvent evaporation method with careful selection of the carrier polymer and drug: polymer ratio.

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Publication Date
Sat Feb 07 2026
Journal Name
Algorithms
An In-Depth Review of Speech Enhancement Algorithms: Classifications, Underlying Principles, Challenges, and Emerging Trends
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Speech enhancement aims to improve speech quality and intelligibility in noisy environments and is important in applications such as hearing aids, mobile communications and automatic speech recognition (ASR). This paper shows a structured review of speech enhancement techniques, classified depending on the channel configuration and signal processing framework. Both traditional and modern approaches are discussed, including classical signal processing methods, machine learning techniques, and recent deep learning-based models. Furthermore, common noise types, widely used speech datasets, and standard evaluation metrics for evaluating speech quality and intelligibility are reviewed. Key challenges such as non-stationary noise, data li

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Publication Date
Sun Jun 01 2025
Journal Name
Cleaner Waste Systems
Performance enhancement of natural asphalt using waste-derived modifiers: Sugarcane molasses and waste engine oil
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The growing demand for sustainable and high-performance asphalt binders has prompted the exploration of waste-derived modifiers. This study investigates the performance enhancement of Natural Asphalt (NA) using Sugarcane Molasses (SM) and Waste Engine Oil (WEO). The modified blends were prepared by partially replacing 50 % NA with varying proportions of SM and WEO ranging from 10 % to 40 % of the total weight of NA. Comprehensive testing was conducted, including penetration, softening point, ductility, viscosity, Bending Beam Rheometer (BBR), Multiple Stress Creep Recovery (MSCR), Energy Dispersive X-ray Spectroscopy (EDX), Fourier Transform Infrared (FTIR) spectroscopy, and Scanning Electron Microscopy (SEM). The results demonstrated that

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Publication Date
Tue Nov 01 2016
Journal Name
Journal Of Cosmetics, Dermatological Sciences And Applications
Direct transplant of melanocytes from normal donor area into vitiligenous recipient area by intralesional injection of melanocytes using spade like needle technique
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KE Sharquie, AA Noaimi, ZN Al-Khafaji…, Journal of Cosmetics, Dermatological Sciences and Applications, 2016 - Cited by 2

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Publication Date
Fri Jan 01 2021
Journal Name
International Journal Of Thermal Sciences
Experimental and numerical investigations of heat transfer enhancement in shell and helically microtube heat exchanger using nanofluids
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Publication Date
Tue Dec 29 2020
Journal Name
Journal Of Accounting And Financial Studies ( Jafs )
Management accounting techniques in product development and achievement customer requirements by adopting the technique of Quality Function Deployment: Applied Research in Baghdad Company for Soft Drinks
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The research aims to apply one of the techniques of management accounting, which is the Quality Function Deployment(QFD) on the Pepsi product in Baghdad Soft Drinks Company and to determine the technical requirements objectively that have been applied in practice in Baghdad Soft Drinks Company / a private shareholding company, as it focuses on meeting the quality requirements and achieving positive quality to provide a product It meets the requirements of current and future customers, hence the importance of research that indicates that the Quality Function Deployment(QFD) is a useful tool to develop the requirements of new products, being a design process driven by customers through their voices, and thus contribute to achieve a competi

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Publication Date
Sun Jan 15 2012
Journal Name
Talanta
Molecularly imprinted polymer as sorbent in micro-solid phase extraction of ochratoxin A in coffee, grape juice and urine
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A simple, environmental friendly and selective sample preparation technique employing porous membrane protected micro-solid phase extraction (μ-SPE) loaded with molecularly imprinted polymer (MIP) for the determination of ochratoxin A (OTA) is described. After the extraction, the analyte was desorbed using ultrasonication and was analyzed using high performance liquid chromatography. Under the optimized conditions, the detection limits of OTA for coffee, grape juice and urine were 0.06 ng g−1, 0.02 and 0.02 ng mL−1, respectively while the quantification limits were 0.19 ng g−1, 0.06 and 0.08 ng mL−1, respectively. The recoveries of OTA from coffee spiked at 1, 25 and 50 ng g−1, grape juice and urine samples at 1, 25 and 50 ng mL

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Publication Date
Sat Dec 27 2025
Journal Name
Pakistan Journal Of Analytical & Environmental Chemistry
Utilizing Konjac Sponge Carrier to EnhancePolyhydroxybutyrate Production Using Bacillus Subtilis and Loquat Seeds in Solid-State Fermentation
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Solid-state fermentation (SSF) is an advanced bioprocess technique with several advantages; however, various challenges including nutrient heterogeneity and limited mass transfer. To address these limitations, this study investigated the use of konjac sponge as an inert carrier for Bacillus subtilis in an adsorbed-carrier SSF (ACSSF) system employing loquat seed hydrolysate, and examined the effects of substrate composition, moisture content, and inoculum size, which were subsequently optimized. The results demonstrate that the adsorbed carrier system enables better contact between the microorganism and the substrate, leading to boosted mass transfer and hence Polyhydroxybutyrate (PHB) production. Under the optimized conditions (pH

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Publication Date
Wed Mar 10 2021
Journal Name
Baghdad Science Journal
The impact of the lack of certain vitamins and minerals intake rate of hair loss in pregnant and breastfeeding women
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The research aims to identify the rates of hair loss during pregnancy and lactation and its relation to the rates get some elements motivator urged through the results of the continued failure to meet the need of daily assessments of these elements, which led to the continuation of Hair Loss

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Publication Date
Thu Apr 30 2020
Journal Name
Journal Of Economics And Administrative Sciences
The Extent of Implementing the Strategy of Solid Waste Management in Baquba City - Poll search
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The research aims to identify the reality of the management strategy followed in the treatment of solid waste in the city of Baquba, and what strategies are used to treat solid waste, and the extent of the application of these strategies, through personal interviews with leading cadres in the Directorate of Baquba Municipality, their assistants and heads of departments, they numbered (55) Individuals. The descriptive method was adopted through a questionnaire prepared to measure the extent of the implementation of the strategy of solid waste management in the city of Baquba and using statistical tools including (arithmetic mean, standard deviation, relative importance, the gap). The research reac

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Publication Date
Tue Mar 31 2020
Journal Name
International Journal Of Heat And Technology
Enhancement of Natural Convection Heat Transfer of Hybrid Design Heat Sink
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