The outstanding evidence of phthalimide pharmacophore in securing enhanced biological activities had encouraged further research and development into phthalimide-based derivatives as potential new drugs. In this study, phthalimide core was hybridized with aldehydes giving integrated imines displaying different types of functionalities and at alternating positions. The resulting compounds, therefore, provide an innovative window to explore possible differential biological effects as antioxidants and anticancer agents. A total of sixteen compounds were synthesized, and each was verified by FT-IR, H NMR, C NMR, and MS characterization. Herein, a facile single-step synthesis method was employed substituting the conventional two-step chemical production routes. Among the sixteen tested compounds, the H7 compound with hydroxyl phenolic group has shown an eminent antioxidant activity with a 19.52% decrease to the IC50 value compared to that of the control standard BHT antioxidant. On the other hand, the halogenated H6 Schiff base structure was successful in securing effective cancer inhibition to both colon and breast cancer cell lines, while maintaining selective action toward normal tissues. Results have collectively indicated the importance and impactful effects of functional groups position and types within similar basic structures, in directing different biological outcomes.
In this paper extensive examples and related counterexamples of the category of -skew -Armendariz rings are given. This category of rings regards a new generalization for the concepts of -skew Armendariz and skew -Armendariz rings. A ring is called -skew -Armendariz if for any ( ) Σ and ( ) Σ such that ( ) ( ) ( ), then ( ) ( ) for each and . First some general properties of -skew -Armendariz rings are studied and then relations between -skew -Armendariz rings and other related rings are investigated. Also various examples of non -skew -Armendariz rings are established.
Let R be a commutative ring with unity .M an R-Module. M is called coprime module (dual notion of prime module) if ann M =ann M/N for every proper submodule N of M In this paper we study coprime modules we give many basic properties of this concept. Also we give many characterization of it under certain of module.
Fao region is characterized by weak soft silty clay to clayey silt thick layer which extends to a depth of about 20 m. The construction of some structures on such soils may needs piles. During the installation of driven piles, the soil geotechnical properties are exposed to significant changes result due to shearing under large shear strains. These changes significantly decrease the shear strength of the virgin soil due to the destruction of soil structure caused by remolding. The degradation of shear strength is usually followed by strength regaining which is called “Thixotropy”. In this study, the thixotropic effect on Fao clay was investigated. Many disturbed and undisturbed soil samples were brought from Fao regi
... Show MoreThe research aims to build a communication apprehention scale for student (females) from preparatory schools .research sample included (400)students (females) were selected from the preparatory . to build a tool for the researchers are several steps , todetermine the meaning of communication apprehention and formulation of the items of the seale according to the linkert method .
In contemporary discourses the debate of most Western thinkers is about the efforts to clarify the normative foundations of democracy. And then, some political thinkers have adopted other models differ in terms of standards for traditional liberal democracy. Be the common goal of democracy will give the formation of a greater role than usual in political liberalism rather than limiting the participatory activity of citizens on the function to give permanent legitimacy to the exercise of state authority. The activity is to be permanently enshrined in the democratic public sphere and the issue must be understood as the source of all political decisions.
Diyala Governorate was recently exposed to high flood waves discharged from Hemrin Dam. Since the dam was at its full capacity during the flood period, these waves were discharged to the Diyala River. Because of the reduction in Diyala River capacity to 750m3/s, the cities and villages on both sides of the river banks were inundated. Thus, the study's objective is to design a flood escape out of the Diyala River, to discharge the flood wave through it. The flood escape simulation was done by using HEC- RAS software. Two hundred twenty-three cross sections for the escape and 30 cross-sections of the Diyala River were used as geometric data. Depending on the geological formation that the escape passed t
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The energy level scheme of 188Os has been established on the basis of
y-y coincidence measurements. Ge (Li) and HPGe detectors were
employed to study the gamma spectra produced in the -decay of 188Re to
188Os. Fourteen new transitions and four new levels at 1660, 1871, 1948
188and 2034 keV are suggested. Relative intensities from singles
measurements, branching ratios and loft values were calculated and
multipolarities, spins and parities deduced
The present work covers the analytical design process of three dimensional (3-D) hip joint prosthesis with numerical fatigue stress analysis. The analytical generation equations describing the different stem constructive parts (ball, neck, tour, cone, lower ball) have been presented to reform the stem model in a mathematical feature. The generated surface has been introduced to FE solver (Ansys version 11) in order to simulate the induced dynamic stresses and investigate the effect of every design parameter (ball radius, angle of neck, radius of neck, neck ratio, main tour radius, and outer tour radius) on the max. equivalent stresses for hip prosthesis made from titanium alloy. The dynamic loading case has been studied to a stumbling ca
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