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Molecular analysis of CFTR gene mutations among Iraqi cystic fibrosis patients
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Abstract<sec> <title>Background

Cystic fibrosis (CF) is an autosomal recessive multisystem disease that results from mutation(s) of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. More than 2100 mutations and polymorphisms have been reported in this gene so far. Incidence and genotyping of CF are under-identified in Iraq. This study aims to determine the types and frequencies of certain CFTR mutations among a sample of Iraqi CF patients. Two groups of patients were included: 31 clinically confirmed CF patients in addition to 47 clinically suspected patients of CF. All confirmed patients had typical, moderate-severe clinical presentation and course of the disease. Molecular analysis was performed on the majority of enrolled patients using the CF-stripAssay® kit supplied by ViennaLab diagnostics, GmbH, Austria.

Results

The mutation-detection rate from the tested 34 mutations in this study was 19.5% and the 8 detected mutations were as follows: 3120+1G>A and W1282X were found in 3 (4.17%) patients each; F508del and R1162X were found in 2 (2.78%) patients each; 3272-26A>G, R347P, I507del, and 2183AA>G were found in 1 (1.38%) patient each. Polymorphic variants of IVS8, namely 5T, 7T, and 9T, were detected in ~ 70%. These results were nearly similar to what was reported in regional countries.

Conclusion

Cystic fibrosis seems to be not rare as previously thought. 3120+1G>A and W1282X are the two most commonly detected mutations. F508del needs to be included in all future tests, while the I507del mutation was uniquely reported in this study but not in regional studies.

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Publication Date
Fri Jan 01 2016
Journal Name
Journal Of Engineering
Some Durability Test of No-Fine Concrete
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In this study, two types of mixes were adopted by using two grading of coarse aggregate. The practical side of this study was to produce no-fine aggregate concrete by using crushed clay brick aggregates. The durability of the produced concrete and internal sulfate attack was studied.      For durability assessment, it is found that the no-fine concrete made with crushed brick aggregate lost about (15-25) % of its compressive strength after being subjected to 60 cycles of wetting and drying with age 120 days. The curing condition showed that the water curing improved the compressive strength with a rate higher than that when sealed or air dry curing were used. The crushed brick no-fine concrete de

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Publication Date
Sat Mar 30 2002
Journal Name
Iraqi Journal Of Chemical And Petroleum Engineering
Preparation, Characterization, and Properties of Barium Titanate
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Publication Date
Sat Mar 30 2013
Journal Name
Iraqi Journal Of Chemical And Petroleum Engineering
Simulation of Cathodic Protection System Using Matlab
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Iraq has a huge network of pipelines, transport crude oil and final hydrocarbon products as well as portable water. These networks are exposed to extensive damage due to the underground corrosion processes unless suitable protection techniques are used. In this paper we collect the information of cathodic protection for pipeline in practical fields (Oil Group in Al Doura), to obtain data base to understand and optimize the design which is made by simulation for the environmental factors and cathodic protection variables also soil resistivity using wenner four terminal methods for survey sites; and soil pH investigations were recorded for these selected fields were within 7-8, and recording the anodes voltage and its related currents for

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Publication Date
Sun Dec 31 2017
Journal Name
College Of Islamic Sciences
The contributions of Arab scientists In (algebra)
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Research summary

Praise be to God, and prayers and peace be upon our master Muhammad, his family and companions until the Day of Judgment.

As for after:

It is the right of every nation to take care of its scientific heritage, and to reveal its human civilizational impact, and the Arabs are the richest nations in heritage, as they had in every period of time a sign and pride, the Arabs fulfilled their duty towards humanity, and they carried out a large part of their scientific activity towards humanity.

Therefore, highlighting some of the scientific aspects of the civilized activity of the Arabs, and removing some of the illusions spread by some malicious people, is a human duty before it is a national duty.

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Publication Date
Wed May 06 2015
Journal Name
Journal Of Social Science Research
The Syntactic and Concurrent Aspects of Emphasizers
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The reinforcing effect of emphasizers can hardly be denied, hence their importance , hence the justification for writing this paper. As a particular type of adverbials , emphasizers form part of a major syntactic class. This study, thus, introduces the topic by first discussing a grammatical category characterized by being mobile and optional. The paper duly shows the scaling effect of emphasizers, their kinds and the transformational selectional rules that are operative in moving them to the right or left of the VP. It also handles their syntactic role as modifiers, their syntactic features,their occurrence or non- occurrence with negation and imperative and the position they occupy in the sentence. The paper also dwells on the agr

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Publication Date
Wed Oct 01 2008
Journal Name
Saudi Medical Journal
Bacille Calmette-Guerin immunotherapy of viral warts.
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KE Sharquie, JR Al-Rawi, AA Al-Nuaimy, SH Radhy, Saudi medical journal, 2008 - Cited by 78

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Publication Date
Mon Dec 30 2002
Journal Name
Iraqi Journal Of Chemical And Petroleum Engineering
Quality Improvement of the Locally Produced Alum
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Publication Date
Thu Apr 01 2021
Journal Name
Iop Conference Series: Earth And Environmental Science
Theoretical structure of Eco-cities: subject review
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Given the importance of ecology and its entry into various fields in general and the urban environment particularly; ecological cities take wide ranges of application at multiple regional and global levels. However, it repeatedly noted that there was a state of cognitive confusion and overlapping in the term ecology comes from the diversity of implementation within several disciplines. Architects, designers, and planners have instilled biological development directly into the formal principles as well as the social structures of the ecological cities. Therefore, the research presents a rapid review of the most relevant areas that dealt with the ecological cities by research and analysis at various levels, from the concept and definition of

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Publication Date
Fri Dec 01 2023
Journal Name
Iop Conference Series: Earth And Environmental Science
Chemotaxonomy of Twelve Mimosoideae Species in Iraq
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Abstract<p>Samples of twelve species belong to mimosoideae were collected from baghdad. The current study aimed to screen the bioactive compounds from leaves methanol extracts of twelve species from Mimosoideae to assess the phytochemical compounds properties. The twelve species of Mimosoideae<italic>were Acacia cyanophylla</italic>Lindl.<italic>, Acacia farnesiana</italic>(L.) Willd.<italic>, Albizia lebbeck</italic>(L.) Benth.,<italic>Albizia julibrissin</italic>Durazz<italic>, Calliandra haematocephala, Leucaena leucocephala</italic>subsp<italic>leucocephala, Leucaena leucocephala</italic>subsp.<italic>glabrata, Mimosa pudica</italic>L.,<j></j></p> ... Show More
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Publication Date
Sun Mar 01 2009
Journal Name
The Third International Conference Of The College Of Science –university Of Baghdad
On Maximal solution of nonlinear operator equation
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