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Molecular analysis of CFTR gene mutations among Iraqi cystic fibrosis patients
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Abstract<sec> <title>Background

Cystic fibrosis (CF) is an autosomal recessive multisystem disease that results from mutation(s) of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. More than 2100 mutations and polymorphisms have been reported in this gene so far. Incidence and genotyping of CF are under-identified in Iraq. This study aims to determine the types and frequencies of certain CFTR mutations among a sample of Iraqi CF patients. Two groups of patients were included: 31 clinically confirmed CF patients in addition to 47 clinically suspected patients of CF. All confirmed patients had typical, moderate-severe clinical presentation and course of the disease. Molecular analysis was performed on the majority of enrolled patients using the CF-stripAssay® kit supplied by ViennaLab diagnostics, GmbH, Austria.

Results

The mutation-detection rate from the tested 34 mutations in this study was 19.5% and the 8 detected mutations were as follows: 3120+1G>A and W1282X were found in 3 (4.17%) patients each; F508del and R1162X were found in 2 (2.78%) patients each; 3272-26A>G, R347P, I507del, and 2183AA>G were found in 1 (1.38%) patient each. Polymorphic variants of IVS8, namely 5T, 7T, and 9T, were detected in ~ 70%. These results were nearly similar to what was reported in regional countries.

Conclusion

Cystic fibrosis seems to be not rare as previously thought. 3120+1G>A and W1282X are the two most commonly detected mutations. F508del needs to be included in all future tests, while the I507del mutation was uniquely reported in this study but not in regional studies.

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Publication Date
Tue Sep 01 2009
Journal Name
Al-nahrain Journal Of Science
Colorimetric assay of aspirin using modified method
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In this research, we did this qualitative and quantitative study in order to improve the assay of aspirin colorimetrically using visible spectrophotometer. This method depends on aqueous hydrolysis of aspirin and then treating it with the ferric chloride acidic solution to give violet colored complex with salicylic acid, as a result of aspirin hydrolysis, which has a maximum absorption at 530nm. This procedure was applied to determine the purity of aspirin powder and tablet. The results were approximately comparative so that the linearity was observed in the high value of both correlation coefficient (R= 0.998) and Determination Coefficient or Linearity (R2= 0.996) while the molar absorpitivity was 1.3× 103 mole

Publication Date
Fri Dec 15 2023
Journal Name
Al-academy
The Philosophy of time in contemporary arts
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Fine art represents part of society's culture. The development of art was accompanied by the penetration of new worlds known as the fourth dimension. After art entered the boundaries of geometry and reduction; He began to break into the absurd, and the form and philosophy of art changed, moving from modernity to what came after it to contemporary. Transforming from a formal form into a symbolic form with philosophical implications linked to the light, audio and kinetic effects as they embody time, the concept became the master of the idea. The research aims to identify the concept of time and its types, then the philosophical concept of time and its reflection on contemporary art, through the analytical study of a selection of contempora

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Publication Date
Wed Jan 01 2025
Journal Name
Journal Of Discrete Mathematical Sciences And Cryptography
Cubic bipolar ideals of a TM-algebra
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This paper refers to studying some types of ideals, specifically cubic bipolar ideals and cubic bipolar T-ideals of TM algebra. It also introduces a cubic bipolar sub-TM-algebra and several important properties of these concepts. The relationships between these ideals and characterizations of cubic bipolar T-ideals are investigated.

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Publication Date
Fri Sep 01 2023
Journal Name
Journal Of Engineering
A Review of Interface Bonding Testing Techniques
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Interface bonding between asphalt layers has been a topic of international investigation over the last thirty years. In this condition, a number of researchers have made their own techniques and used them to examine the characteristics of pavement interfaces. It is obvious that test findings won't always be comparable to the lack of a globally standard methodology for interface bonding. Also, several kinds of research have shown that factors like temperature, loading conditions, materials, and others have an impact on surface qualities. This study aims to solve this problem by thoroughly investigating interface bond testing that might serve as a basis for a uniform strategy. First, a general explanation of how

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Publication Date
Tue Oct 01 2024
Journal Name
Computational And Theoretical Chemistry
The curious case of S4N4 − A reinvestigation
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Publication Date
Mon Feb 01 2021
Journal Name
Journal Of Physics: Conference Series
Cubic ideals of semigroup in KU-algebra
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Abstract<p>In this work, we study of the concept of a cubic set of a semigroup in KU-algebra. Firstly, we study a cubic sub KU-semigroup and achieve some results in this notion. And then, we get a relation between a cubic sub KU-semi group and a level set of a cubic set. Moreover, we define some cubic ideals of this structure and we found relationships between these ideals.</p><p>2010 AMS Classification. 08A72, 03G25, 06F35</p>
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Publication Date
Thu Apr 01 2021
Journal Name
Iop Conference Series: Earth And Environmental Science
Theoretical structure of Eco-cities: subject review
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Given the importance of ecology and its entry into various fields in general and the urban environment particularly; ecological cities take wide ranges of application at multiple regional and global levels. However, it repeatedly noted that there was a state of cognitive confusion and overlapping in the term ecology comes from the diversity of implementation within several disciplines. Architects, designers, and planners have instilled biological development directly into the formal principles as well as the social structures of the ecological cities. Therefore, the research presents a rapid review of the most relevant areas that dealt with the ecological cities by research and analysis at various levels, from the concept and definition of

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Publication Date
Wed Nov 01 2023
Journal Name
Journal Of Interdisciplinary Mathematics
Interval valued fuzzy ideals of TM-algebra
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We introduce the notion of interval value fuzzy ideal of TM-algebra as a generalization of a fuzzy ideal of TM-algebra and investigate some basic properties. Interval value fuzzy ideals and T-ideals are defined and several examples are presented. The relation between interval value fuzzy ideal and fuzzy T-ideal is studied. Abstract We introduce the notion of interval value fuzzy ideal of TM-algebra as a generalization of a fuzzy ideal of TM-algebra and investigate some basic properties. Interval value fuzzy ideals and T- ideals are defined and several examples are presented. The relation between interval value fuzzy ideal and fuzzy T-ideal is studied.

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Publication Date
Fri Dec 01 2023
Journal Name
Iop Conference Series: Earth And Environmental Science
Chemotaxonomy of Twelve Mimosoideae Species in Iraq
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Abstract<p>Samples of twelve species belong to mimosoideae were collected from baghdad. The current study aimed to screen the bioactive compounds from leaves methanol extracts of twelve species from Mimosoideae to assess the phytochemical compounds properties. The twelve species of Mimosoideae<italic>were Acacia cyanophylla</italic>Lindl.<italic>, Acacia farnesiana</italic>(L.) Willd.<italic>, Albizia lebbeck</italic>(L.) Benth.,<italic>Albizia julibrissin</italic>Durazz<italic>, Calliandra haematocephala, Leucaena leucocephala</italic>subsp<italic>leucocephala, Leucaena leucocephala</italic>subsp.<italic>glabrata, Mimosa pudica</italic>L.,<j></j></p> ... Show More
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Publication Date
Thu Apr 01 2021
Journal Name
Iop Conference Series: Earth And Environmental Science
Theoretical structure of Eco-cities: subject review
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Abstract<p>Given the importance of ecology and its entry into various fields in general and the urban environment particularly; ecological cities take wide ranges of application at multiple regional and global levels. However, it repeatedly noted that there was a state of cognitive confusion and overlapping in the term ecology comes from the diversity of implementation within several disciplines. Architects, designers, and planners have instilled biological development directly into the formal principles as well as the social structures of the ecological cities. Therefore, the research presents a rapid review of the most relevant areas that dealt with the ecological cities by research and analys</p> ... Show More
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