SURVIVIN TARGETING; AN IN SILICO APPROACH FOR 
ANTICANCER DESIGN

Aymen Almulla Almulla; Entissar Almulla Almulla

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Publication Date

Thu Jul 18 2019

Journal Name

Annals Of Tropical Medicine & Public Health

Volume

21

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SURVIVIN TARGETING; AN IN SILICO APPROACH FOR ANTICANCER DESIGN

Survivin

Drug Design

Aymen Almulla Almulla

Entissar Almulla Almulla

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Survivin, a member of inhibitor of apoptosis family is increasingly used as a target for cancer therapy design because it has a key role in cell growth and inhibition of cell apoptosis. Also it can be used as a biomarker for targeting cancer because it is found in almost all cancer but not normal cells. Our strategy was to design (computationally) a molecule to be used as survivin inhibitor. This molecule was named lead10 and was used furthermore to find (virtually) existing drugs with a good survivin inhibition activity.

Publication Date

Wed Jul 12 2017

Journal Name

Der Chemica Sinica

An Efficient One-Pot Approach for the Formation of Phenanthridine Derivative; Synthesis and Spectral Characterisation

Baidaa

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The preparation of the phenanthridine derivative compound was achieved by adopting an efficient one-pot synthetic approach. The condensation of an ethanolic mixture of benzaldehyde, cyclohexanone and ammonium acetate in a 2:1:1 mole ratio resulted in the formation of the title compound. Analytical and spectroscopic techniques were used to confirm the nature of the new compound. A mechanism for the formation of the phenanthridine moiety that is based on three steps has been suggested

Publication Date

Wed Jan 01 2020

Journal Name

Fme Transactions

Development of automated liquid filling system based on the interactive design approach

Abdullah O.I.

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The automatic liquid filling system is used in different applications such as production of detergents, liquid soaps, fruit juices, milk products, bottled water, etc. The automatic bottle filling system is highly expensive. Where, the common filling systems required to complex changes in hardware and software in order to modify volume of liquid. There are many important variables in the filling process such as volume of liquid, the filling time, etc. This paper presents a new approach to develop an automatic liquid filling system. The new proposed system consists of a conveyor subsystem, filling stations, and camera to detect the level of the liquid at any instant during the filling process. The camera can detect accurately the leve

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Publication Date

Thu Feb 01 2024

Journal Name

Russian Journal Of Bioorganic Chemistry

Synthesis, Identification, Antioxidant, Molecular Docking, and In Silico ADME Study for Some New Derivatives Containing Thiourea Moiety

thiourea

antioxidant

DPPH

molecular docking

ADME

Lipinski rule

anti-breast cancer agent

Asmaa Abdulbaqi

Oday H.R.

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Objective: Synthesized a series of new thiourea (TU) derivatives, tested their antioxidant activity, and investigated their expected biological activity by theoretical study (computational methods). Methods: The derivatives were made using a one-pot reaction with two steps. Initially, succinyl chloride was mixed with KSCN to make succinyl isothiocyanate. Then, primary and secondary amines were used to make TU derivatives. The theoretical studies were done by Swiss ADME and molecular docking via Genetic Optimization of Linkage Docking (GOLD). Then evaluate antioxidant activity using the DPPH scavenging method. Results: FT-IR, 1H NMR, and 13C NMR spectroscopy show the verification of all the prepared derivatives. Compounds (II), (VIII),

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Publication Date

Thu Dec 09 2021

Journal Name

Revista Latinoamericana De Hipertension

Synthesis, chemical hydrolysis and biological evaluation of doxorubicin carbamate derivatives for targeting cancer cell

Mohammed Hassan

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Publication Date

Tue Feb 01 2022

Journal Name

Macromolecular Symposia

Synthesis of 5‐Fluorouracil–Naproxen Conjugates as a Mutual Prodrug for Targeting Cancer Tissues

Mohammed H.

Azhar Mahdi

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AbstractA new 5‐fluorouracil–naproxen conjugate is synthesized as a mutual prodrug for targeting cancer tissues. The structure of the target compound and their intermediate are characterized by their melting point, IR, 1H NMR, 13C NMR, and elemental microanalysis. The cytotoxic activity is preliminarily evaluated using nonsmall lung cancer CRL‐2049, human breast cancer CAL‐51, and one type of normal cell line; rat embryo fibroblast cell line. The synthesized compound shows a good cytotoxic effect at the cancer cell and no significant effect at rat embryo fibroblast cell line.

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Publication Date

Fri Dec 15 2023

Journal Name

Al-academy

Phenomenology as an approach to seeing the aesthetics of ugliness in contemporary art designs

phenomenological approach

contemporary arts design

aesthetics of ugliness

Tahani

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With a descriptive and analytical approach, it discusses the concept of phenomenology as an approach to seeing the aesthetics of ugliness as one of the concepts associated with the aesthetic experience in contemporary art designs, as it is the result of communication between artistic production and the recipient, which leads to creating a state of aesthetic pleasure. A phenomenological method is used to uncover the aesthetics of ugly and to connect ugliness and beauty since ugliness in aesthetics incorporates beauty as a modern aesthetic vision from the phenomenological perspective. The study investigated aesthetics as a phenomenon of perception, sensory knowledge, and the aesthetic response to the production of designs in contemporary a

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Publication Date

Sun Oct 13 2019

Journal Name

Spe Kuwait Oil & Gas Show And Conference

Optimization of Fracture Parameters for Hydraulic Fractured Horizontal Well in a Heterogeneous Tight Reservoir: An Equivalent Homogeneous Modelling Approach

upstream oil & gas

equivalent homogeneous model

heterogeneous model

optimum number

hydraulic fracturing

simulation model

tight gas reservoir

saturation

model 1

optimization

Omar

Mofazzal

Asaad

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AbstractBuilding numerical reservoir simulation model with a view to model actual case requires enormous amount of data and information. Such modeling and simulation processes normally require lengthy time and different sets of field data and experimental tests that are usually very expensive. In addition, the availability, quality and accessibility of all necessary data are very limited, especially for the green field. The degree of complexities of such modelling increases significantly especially in the case of heterogeneous nature typically inherited in unconventional reservoirs. In this perspective, this study focuses on exploring the possibility of simplifying the numerical simulation pr ... Show More

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Publication Date

Tue Dec 07 2021

Design and numerical verification of a polarization-independent grating coupler using a double-layer approach for visible wavelengths applications

Farooq Abdulghafoor

Shelan Khasro

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(1)

Publication Date

Fri Feb 01 2019

Journal Name

Indian Journal Of Natural Sciences

Design and Test of Electrochemistry of Electrodes Catalysis for an Alkaline Fuel Cell

Haleemah J

Nathera

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Publication Date

Sat Jan 09 2021

Journal Name

Journal Of Control, Automation And Electrical Systems

Design of an Adaptive Linear Quadratic Regulator for a Twin Rotor Aerodynamic System

Rafal Fawzi

Omar Waleed

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