Background: White spot lesions are esthetic problems caused by subsurface enamel demineralization that seen as white opacity. Aim of the study: This study aimed to evaluate and to compare the color change after the treatment of the white spot lesions with resin ‹nϔ‹Žtrƒt‹on and micro abrasion. Materials and Methods: rt‹ϔ‹…‹ƒŽ white spot lesions were generated on 48 premolar teeth by the use of a demineralization solution. The teeth were randomly divided using the Diagnodent into three study groups (16 teeth for each group) depending on the depth of the induced lesions: outer enamel, inner enamel and outer dentine. Then each group was fatherly subdivided into two groups (8 teeth for each group) the ϔ‹rst group was treated with resin ‹nϔ‹Žtrƒt‹onǡ while the second one was treated with micro abrasion. For each group, Spectrophotometric examination was performed at three points: baseline (T0), after producing the lesion (T1), and after the treatment (T2). Results: While the mean of ΔE between (T0-T1) showed a s‹‰n‹ϔ‹…ƒnt difference between the outer and the inner enamel, the outer enamel and the outer dentine, there was no s‹‰n‹ϔ‹…ƒnt difference between the inner enamel and the outer dentine. On the other hand, the mean of ΔE between (T1-T2) of the three layers of the lesions showed that there was no s‹‰n‹ϔ‹…ƒnt difference between all the layers when the resin ‹nϔ‹Žtrƒt‹on was used. However, there was a s‹‰n‹ϔ‹…ƒnt difference when the micro abrasion was used. The ΔE between (T0-T2) shows no s‹‰n‹ϔ‹…ƒnt difference between the three layers of the lesions and between the two materials, (p>0.05). Conclusion: Results of the present study revealed that the deeper the white spot lesion the more the color difference it was, and the resin ‹nϔ‹Žtrƒt‡s was excellent in improving the color of the lesion with the same effectiveness as the microabrsion was.