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Synthesis and biological activity evaluation of new isatin-gallate hybrids as antioxidant and anticancer agents (in vitro) and in silico study as anticancer agents and coronavirus inhibitors
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Background: The hybrid compounds hold promise for developing novel pharmaceuticals, potentially exhibiting greater activity, mainly against viruses and cancer diseases, than their components.

Objective: In this study, researchers explored the potential synergistic effects of hybrid molecules by designing and synthesizing a series of isatin-gallate hybrids, denoted as N’-(5-substituted-2-oxoindolin-3-ylidene)-3,4,5-trihydroxybenzohydrazide (3a–d).

Methods: Isatin-gallate hybrids (3a–d) were synthesized by reacting gallic hydrazide with each of the isatin analogs (2a–d). The structures of all produced compounds were described using spectrum methods such as fourier transform infrared (FTIR), 1H-nuclear magnetic resonance spectroscopy (1H-NMR), and physicochemical attributes. The evaluation of the tested hybrids (3a–d) involved assessing their in vitro antioxidant activities using the α, α-diphenyl-β-picrylhydrazyl (DPPH) free radical scavenging method and cytotoxic activities through the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] colorimetric assay for measuring cellular growth. Furthermore, in silico analysis was applied to the final hybrids to evaluate their effects as anticancer and anti-coronavirus agents.

Conclusion: Among the examined hybrid compounds, 3b demonstrated substantial in vitro antioxidant and cytotoxic activities. In silico analysis revealed slight variations in the anticancer activity of compounds 3a–d, with differing affinities observed across various cancer cell lines. Additionally, these compounds exhibited moderate efficacy in inhibiting coronavirus activity.

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Publication Date
Tue Oct 31 2023
Journal Name
College Of Islamic Sciences
Asking for permission and its legal ruling
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Praise be to God, Lord of the Worlds, and the best blessings and peace be upon our master Muhammad and all his family and companions, and those who follow them with goodness until the Day of Judgment. . And after:

God created man in the best manner, and subjugated the universe to him and favored him over the rest of creation when he gave him a mind to contemplate and know how to distinguish between the harmful and the beneficial, the bad and the good, in order to exploit him in achieving the meaning of worship, because it is the highest goal of his creation. God Almighty said (And I did not create the jinn and mankind. Except that they worship them.” [Al-Dhariyat: 56]

If knowing what is harmful from what is beneficial a

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Publication Date
Sun Nov 01 2020
Journal Name
Solid State Technology
Access Control Security Review: Concepts and Models
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HS Saeed, SS Abdul-Jabbar, SG Mohammed, EA Abed, HS Ibrahem, Solid State Technology, 2020

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Publication Date
Sat Jan 01 2022
Journal Name
Middle East African Journal Of Ophthalmology
Obstacles and challenges facing Iraqi women ophthalmologists
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Publication Date
Wed Dec 30 2015
Journal Name
College Of Islamic Sciences
Making up missed fasts Terms and conditions
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The obligatory duty must be fulfilled for attachment to the discharge, whatever the reasons for the missingness, whether it is left by mistake or omission or deliberate, whether with or without excuse. What is likely in this research to spend Ramadan on laxity.
The one who delayed making up Ramadaan fasts until he realized another Ramadaan, fasted the second and spent the first after him, and no ransom on him, either with an excuse or without an excuse.

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Publication Date
Wed Jun 01 2022
Journal Name
Innovations
Proteolytics, Their Functional Role and Practical Applications
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RMK Al-Zaid, AT Al-Musawi, SJ Mohammad

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Publication Date
Wed Dec 30 2015
Journal Name
College Of Islamic Sciences
Tolerance and its impact on building society
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Tolerance and its impact on building society

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Publication Date
Mon Aug 01 2016
Journal Name
Arpn Journal Of Engineering And Applied Sciences
SURVEY ON VANET TECHNOLOGIES AND SIMULATION MODELS
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Vehicular ad hoc network (VANET) is a distinctive form of Mobile Ad hoc Network (MANET) that has attracted increasing research attention recently. The purpose of this study is to comprehensively investigate the elements constituting a VANET system and to address several challenges that have to be overcome to enable a reliable wireless communications within a vehicular environment. Furthermore, the study undertakes a survey of the taxonomy of existing VANET routing protocols, with particular emphasis on the strengths and limitations of these protocols in order to help solve VANET routing issues. Moreover, as mobile users demand constant network access regardless of their location, this study seeks to evaluate various mobility models for vehi

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Publication Date
Thu Jan 01 2015
Journal Name
Iet Colloquium On Millimetre-wave And Terahertz Engineering & Technology 2015
Millimetre wave semiconductor based isolators and circulators
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Publication Date
Tue Oct 11 2022
Journal Name
College Of Islamic Sciences
SUBSTITUTION SEMANTICS (METAPHOR) AND SEMANTICS ADJOINING (METONYMY
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Abstract

Praise be to God, Lord of the Worlds, and prayers and peace be upon the most honorable of creation, Muhammad, whom God sent as a mercy to the worlds, and his infallible, pure, and pure family, and his faithful companions

I did not find anyone who studied stylistic structures except for one study, which is (The Literature of Imam Al-Jawad (peace be upon him), a stylistic study by the student Mina Reda Kazem, a master’s thesis), and it did not address the Hadi and the military men (peace be upon them) as the text of those texts. Coherently complementing each other.

I decided to stand by this heritage as a single text in a uniform period of time approximately from the year 195-260 AH, some

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Publication Date
Thu Jan 10 2019
Journal Name
Journal Of The College Of Education For Women
Development Gap Between Rural and Urban Stabilizers
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This research concluded that after what has been presented an analysis of the topics that the process of measuring the level of development and then the development gap is the need to assess the results to set policy and to formulate plans and goals, and to see the development priorities of the place or a particular sector. The purely economic development led to negative effects on the spatial scale and the most important of these effects arise multidimensional social and urban development gaps as well as the economic dimension. So it must exceed the concept of economic framework, to include all dimensions of development spatially and sectorally to provide correct and clear base for planners and development policies and strategies for de

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