The performance of flexible pavements is significantly impacted by the permanent deformation (rutting) of asphalt pavements. Rutting shortens the pavement's useful service life and poses significant risks to those using the highway since it alters vehicle handling characteristics.. The aim of this research is to evaluate the permanent deformation of asphalt mixtures under different conditions,to achieve this aim 108 cylindrical specimens has been prepared and tested under repeated loading in uniaxial compression mode. Five factors were considered in this research, these factors represent the effect of environmental condition and traffic loading as well as mixture properties, they include testing temperature, loading condition (stress level and duration), mixture properties (asphalt type and content). The permanent deformation is evaluated in term of the following parameters, accumulation of permanent strain, axial resilient micro strain, initial permanent strain (intercept, a), accumulation rate of permanent deformation (slope, b), rate of decrease in permanent deformation (α) and constant of proportionality between permanent and elastic strains (µ). Based on the repeated load test results, it was found that when the testing temperature increased from 20 to 40◦C, the permanent strain and intercept increased by a factor of 4.8 and 1.9, respectively. Further increase of the testing temperature from 40 to 60◦C, resulted in the permanent strain increment by a factor of 5.13 whereas the intercept by a factor 2.18. In addition, the test data shows the permanent strain value for load duration of 0.4 sec. is 1.64 times the value for 0.1 sec. Finally, the findings showed that the resilient response of the substance is comparatively more sensitive to asphalt content than the plastic response. Furthermore, the rutting resistance is highly affected by the variables considered in this research.