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Synergistic Effects of 2-Deoxy-D-Glucose and Cinnamic Acid with Erlotinib on NSCLC Cell Line
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Background: In spite of all efforts, Non-small cell lung cancer (NSCLC) is a fatal solid tumor with a poor prognosis as of its high metastasis and resistance to present treatments. Tyrosine kinase inhibitors (TKI) such as erlotinib are efficient in treating NSCLC but the emergence of chemoresistance and adverse effects substantially limits their single use. Objective: in this study, the combination treatments of either 2-deoxy-D-glucose (2DG) or cinnamic acid (CINN) with erlotinib (ERL) were tested for their possible synergistic effect on the proliferation and migration capacity of NSCLC cells. Methods: In this study, NSCLC model cell line A549 was used to investigate the effects of single compounds and their combination on cell growth inhibition, clonogenic potential, and migration capacity. Next, the Combination index (CI) and the Dose-Reduction Index (DRI) were determined to determine the nature of the drug’s combination and to measure how many folds the dose could be lowered for each drug in a synergistic combination. Results: the combination treatment demonstrated more significant inhibition of viability of A549 cells compared to individual therapy. Our data show that CINN augments the sensitivity to erlotinib in all doses tested. The combination of 2DG or CINN with erlotinib also reduced the clonogenicity of NSCLC cells up to 67% and 85%, respectively, as compared to the erlotinib single treatment. Furthermore, CINN +ERL decreased the migratory ability of A549 cells by 3-fold and further induced much more apoptotic cell death phenotypes. Conclusion: in summary, co-administration of 2DG or cinnamic acid with erlotinib increases the inhibitory effects of erlotinib on NSCLC cell tumorigenicity and migration.

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Publication Date
Wed Apr 20 2022
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
(θ1,θ2) - Derivation Pair on Rings
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     Ring theory is one of the influential branches of abstract algebra. In this field, many algebraic problems have been considered by mathematical researchers who are working in this field. However, some new concepts have been created and developed to present some algebraic structures with their properties. Rings with derivations have been studied fifty years ago, especially the relationships between the derivations and the structure of a ring. By using the notatin of derivation, many results have been obtained in the literature with different types of derivations. In this paper, the concept of the derivation theory of a ring has been considered. This study presented the definition of

     Ring theory is one of the influ

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Publication Date
Sat Sep 30 2023
Journal Name
Al–bahith Al–a'alami
Arab Women’s Self-Performance on Instagram
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This study investigates self-perception and self-branding on Instagram among young Arab women in the UAE, focusing on how they curate, negotiate and perform their digital identities and whether their digital self-presentation in any way compromises their sense of authenticity. The study is based on 11 interviews with young women in the UAE, between the ages of 20 and 30, in addition to online observation to follow the participants’ activities on Instagram. The study demonstrates that while social and digital media platforms may play a role in “empowering” Arab women, women tend to set their boundaries of authenticity shaped according to their audience’s expectations and their in-groups. This confirms the r

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Publication Date
Thu Jun 30 2022
Journal Name
Iraqi Journal Of Science
Topology on Rough Pentapartitioned Neutrosophic Set
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     The main focus of this article is to introduce the notion of rough pentapartitioned neutrosophic set and rough pentapartitioned neutrosophic topology by using rough pentapartitioned neutrosophic lower approximation, rough pentapartitioned neutrosophic upper approximation, and rough pentapartitioned neutrosophic boundary region. Then, we provide some basic properties, namely operations on rough pentapartitioned neutrosophic set and rough pentapartitioned neutrosophic topology. By defining rough pentapartitioned neutrosophic set and topology, we formulate some results in the form of theorems, propositions, etc. Further, we give some examples to justify the definitions introduced in this article.

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Publication Date
Sun Oct 22 2023
Journal Name
Iraqi Journal Of Science
On δ-small M-Projective Modules
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In this paper we study the concepts of δ-small M-projective module and δ-small M-pseudo projective Modules as a generalization of M-projective module and M-Pseudo Projective respectively and give some results.

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Publication Date
Mon Apr 11 2016
Journal Name
Annals Of Fuzzy Mathematics And Informatics
Some notions on convex soft sets
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Publication Date
Mon Apr 15 2019
Journal Name
Proceedings Of The International Conference On Information And Communication Technology
A steganography based on orthogonal moments
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Publication Date
Sat Aug 20 2022
Journal Name
Journal Of Legal Sciences
The penal rule on the blank
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          The source, the objective penal rule that consists of two parts: crimination & penalty, the part of crimination is the (ORDER) that means the mater that has been avoided.

 (THE ORDER) or the order that has been done (THE PROHIBITION) , it is an order or prohibition has been enacted by the legislator to the adult person to subject to the penal rule , but the part of the penalty is the legal  effect that resulted  to violate the crimination part , and the source is to mention the penal rule with two parts in one penal code , but maybe  to be mentioned as separated matter more than one legislative code in the law or contemporary different laws , there is

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Publication Date
Sun Apr 08 2018
Journal Name
Al-khwarizmi Engineering Journal
Experimental Study on Solar Air Heating
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Abstract

 

A new type of solar air heater was designed, fabricated, and tested in Baghdad, Iraq winter conditions. The heater consists of two main parts. The horizontal section was filled with the black colored iron chip while the vertical part has five pipes filled with Iraqi paraffin wax. A fan was fixed at the exit of the air. Two cases were studied: when the air moved by natural convection and when forced convection moved it. The studied air heater has proven its effectiveness as it heated the air passing through it to high temperatures. The results manifest that using little air movement makes the temperatures, stored energies, and efficiencies of the two studied cases converge

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Publication Date
Sat Jun 01 2019
Journal Name
2019 Ieee International Conference On Automatic Control And Intelligent Systems (i2cacis)
Study on Solar Panel Cleaning Robot
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Publication Date
Thu Nov 12 2020
Journal Name
Journal Of Petroleum Research And Studies
Production Optimization for Natural Flow and ESP Well A Case Study on Well NS-5 Mishrif Formation-Nasriya Oil Field
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As the reservoir conditions are in continuous changing during its life, well production rateand its performance will change and it needs to re-model according to the current situationsand to keep the production rate as high as possible.Well productivity is affected by changing in reservoir pressure, water cut, tubing size andwellhead pressure. For electrical submersible pump (ESP), it will also affected by numberof stages and operating frequency.In general, the production rate increases when reservoir pressure increases and/or water cutdecreases. Also the flow rate increase when tubing size increases and/or wellhead pressuredecreases. For ESP well, production rate increases when number of stages is increasedand/or pump frequency is

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