Methotrexate (MTX), a folic acid antagonist is widely used for the treatment of a variety of tumors. In the present study, the possible protective effect of aqueous green tea extract (AGTE) in methotrexate-induced haematotoxicity was investigated.Four main groups of white Albino rats were used: control group, (MTX) group, following a single dose of MTX (20 mg/kg, i.p.) saline was administered for 5 days. (AGTE) group, was treated with 1.25% concentration of AGTE only for 12 days and the (MTX+AGTE) group, in thism group rats received different concentrations of AGTE (0.625, 1.25 and 2.5%), as their sole source of drinking water, 7days before and 5 days after MTX treatment. MTX induced significant decreases in RBC, Hb, Hct, WBC and platelets. Whereas increased MCV and MCH. Moreover, the concentrations of AGTE play a major role.The best protective effects of AGTE treatment were observed at the concentration 1.25% While 0.625% and 2.5% AGTE had no protective effects on haematological parameters.
Background: The mechanical and physical properties of Polymethyl methacrylate (PMMA) don’tfulfill the entire ideal requirements of denture base materials. The purpose of this study was to produce new modified polymer nanocomposite (PMMA /ZrO2-TiO2) andassess itsimpact strength, transverse strength and thermal conductivity in comparison to the conventionalheat polymerized acrylic resin. Materials and Methods: Both ZrO2 and TiO2nano fillers were silanized with TMSPM (trimethoxysilyl propyl methacrylate) silane coupling agent before beingdispersed by ultrasonication with the methylmethacrylate (monomer) and mixed with the polymer by means of 2% by weight in (1:1) ratio, 60 specimens were constructed by conventional water bath processing
... Show MoreThis study aimed to investigate the antibacterial effect of Cinnamomum verum ethanolic extract against Proteus mirabilisisolated from the oral cavities of humans and dogs. Fifty samples, collected from both humans and dogs, corresponding to isolates obtained using the primary and VITEK 2 systems, yielded eight isolates that were positive for P. mirabilis. Different doses of the Cinnamomum verum extract were evaluated against the isolated P. mirabilis cultures, ranging from 125 to 2000 micrograms. Significant results were observed starting from 500 micrograms, yielding a 19 mm zone of inhibition. These results corroborate the findings of the GC-MS test on the extract, confirming the antibacterial properties of the active compounds resulting
... Show MoreBilastine (BL) is a novel non-sedating second-generation antihistamine, and its bioavailability is about 60%. Objective: To compare the bioavailability of prepared oral self-nanoemulsions of BL (BL-SNE) with that of pure BL and marketed tablets. Methods: Four groups of Wistar rats were used in this study, each with six rats weighing between 200 and 250 g. They were treated orally using a a gavage tube. The groups were fed either with conventional tablets ("Alerbix®") after being ground and dispersed with deionized water (DIW), treated with BL-SNE or fed with pure BL powder suspension. The fourth group did not receive any medication. The concentration of BL in the rat’s plasma was measured using HPLC. We used Trandolapril as an an interna
... Show MoreThe aim of this study was investigating the correlation between elevation of Prolactin levels and the increase of the concentrations of total sialic acids. The study was performed on 149 women consisted of 93 infertile hyperprolactinimic women (patients), age ranged16-38 years old, and 56 normoprolactinemic women as a control group, 18-37 years old. Serum prolactin (PRL) and gonadotroph hormones (Follicle stimulating hormone FSH and Luteinizing hormone LH) were measured using enzymatic immunoassay (EIA) method, resorcinol method for serum total sialic acids (SIA). Patients were divided into four groups, each group represented the level of prolactin of infertile women as follow: G1= (21-30), G2= (31-40), G3= (41-50), and G4= (51-60) ng/mL. S
... Show MoreStrategies to reduce obesity have become main priority for many health institution and health staff around the world, as the prevalence of obesity has risen and exacerbated in most of the world mainly because of the modern life style which tend to be more sedentary with an increase eating unhealthy fast western food. Many years ago, the lipid-lowering drug simvastatin; and omega-3 were considered as a traditional lipid-lowering drug that have been well-documented to possess anti-inflammatory, cardioprotective and triglyceride-lowering properties; and their co-administration may demonstrate a complementary effect in lowering patients' triglycerides and total cholesterol to treat atherosclerosis. Many previous studies have
... Show MoreZinc is an essential element for the body; it is involved in many enzymes and has a role in many physiological processes; glucose metabolism stands ahead of them. Also, chromium has been used recently as a food supplement in regime systems, So it's essential to evaluate the effects of these two elements in a diabetic state and evaluate their antidiabetic ability. Seventy male adult mice were used and grouped into seven groups. Group 1: received no treatment. Group 2 received 10mg/kg body weight daily orally of ZnONPs for a month. Group 3 received 1mg/kg body weight for a month daily oral of CrO3NPs. Group 4: received a single dose of 150mg/kg body weight of alloxan. Group 5 received a single alloxan dose of 150 mg/kg and daily oral 10 mg/kg
... Show MoreThis work deals with the nematode parasitesfrom the midgut of (16) specimens of Green
toad (Bufo viridis) Laurenti, 1768 collected from Baghdad area,central Iraq.
The parasites are:Cosmocercoides variabilis (Cosmocercidae) that considered as the first
report in Iraq on it and Oswaldocruzia filiformis (Molineidae).
For the most reliable and reproducible results for calibration or general testing purposes of two immiscible liquids, such as water in engine oil, good emulsification is vital. This study explores the impact of emulsion quality on the Fourier transform infrared (FT-IR) spectroscopy calibration standards for measuring water contamination in used or in-service engine oil, in an attempt to strengthen the specific guidelines of ASTM International standards for sample preparation. By using different emulsification techniques and readily available laboratory equipment, this work is an attempt to establish the ideal sample preparation technique for reliability, repeatability, and reproducibility for FT-IR analysis while still considering t
... Show MoreStrengthening with carbon fiber-reinforced polymers (CFRP) has become one of the most significant methods of enhancing the flexural strength of reinforced concrete members. Extensive research has shown that externally-bonded CFRP sheets tend to debond from the soffit of the concrete members at much lower strains, compared with CFRP rupture strain. Different types of anchorage system have been developed to prevent or delay the debonding type failure, which leads to a higher utilisation of the CFRP sheets before failure occurs. This paper summarises some of the most efficient types of anchorage systems that have shown significant enhancement in terms of increasing the flexural bending c