Escherichia coli (E. coli) is a frequent gram-negative bacterium that causes nosocomial infections, affecting more than 100 million patients annually worldwide. Bacterial lipopolysaccharide (LPS) from E. coli binds to toll-like receptor 4 (TLR4) and its co-receptor’s cluster of differentiation protein 14 (CD14) and myeloid differentiation factor 2 (MD2), collectively known as the LPS receptor complex. LPCAT2 participates in lipid-raft assembly by phospholipid remodelling. Previous research has proven that LPCAT2 co-localises in lipid rafts with TLR4 and regulates macrophage inflammatory response. However, no published evidence exists of the influence of LPCAT2 on the gene expression of the LPS receptor complex induced by smooth or rough bacterial serotypes. We used RAW264.7—a commonly used experimental murine macrophage model—to study the effects of LPCAT2 on the LPS receptor complex by transiently silencing the LPCAT2 gene, infecting the macrophages with either smooth or rough LPS, and quantifying gene expression. LPCAT2 only significantly affected the gene expression of the LPS receptor complex in macrophages infected with smooth LPS. This study provides novel evidence that the influence of LPCAT2 on macrophage inflammatory response to bacterial infection depends on the LPS serotype, and it supports previous evidence that LPCAT2 regulates inflammatory response by modulating protein translocation to lipid rafts.
José Echegaray, dramaturgo español, obtuvo premio Nóbel de literatura en (1904), político, orador, economista y dramaturgo. Con su obra "El gran Galeoto" en 1881, llegó a la cumbre de la popularidad.
Henrik Ibsen, dramaturgo noruega, creador del drama moderno, por sus obras realistas que abordan problemas psicológicos y sociales. Y a que fue el iniciador del teatro de tesis del teatro social. Ibsen, dramaturgo noruega, cuya obra influyó notablemente en el teatro europeo de finales del s. XIX y principios del XIX ; en gran parte en la obra de Echegaray, Galdós (1) y Benavente (2).
Los presentes autores empezaron sus producciones bajo el romanticismo que fue poco a poco añadiendo ideas del naturalismo y el realismo dramátic
José Echegaray, dramaturgo español, obtuvo premio Nóbel de literatura en (1904), político, orador, economista y dramaturgo. Con su obra "El gran Galeoto" en 1881, llegó a la cumbre de la popularidad.
Henrik Ibsen, dramaturgo noruega, creador del drama moderno, por sus obras realistas que abordan problemas psicológicos y sociales. Y a que fue el iniciador del teatro de tesis del teatro social. Ibsen, dramaturgo noruega, cuya obra influyó notablemente en el teatro europeo de finales del s. XIX y principios del XIX ; en gran parte en la obra de Echegaray, Galdós (1) y Benavente (2).
Los presentes autores empezaron sus producciones bajo el romanticismo que fue poco a poco añadiendo ide
... Show MoreThis paper deals with the process of evaluating the performance of agricultural activity in Iraq and in particular the agricultural initiative launched by Prime Minister Nuri al-Maliki, during the period from 2008 - 2011. Where it is possible to use criteria or indicators that are fabricated by a statement on the calendar and the results of which may be by comparing planned performance with actual performance or the evaluation of the actual performance of successive periods selected. With an emphasis on the agricultural initiative is subject to the evaluation process by implementing and destinations specialized loan funds its own projects as one of the agricultural lending. With the need to co
... Show MoreThe research aims to identify Determination talent management dimensions of (attracting talent, developing talent, directing talent, performance management talent, retain talent) in the entrepreneurial performance of the organization dimensions of (advance planning, efficiency, effectiveness), so search occupies the extreme importance of being treated important and recent issue of the performance Entrepreneuria, management talent, aware of the importance of the subject and expected results of the company surveyed, was an analysis of data obtained through field visits in addition to the questionnaire and interviews, highlights were the results that have been reached to take the sample into account all the management requirements knack of att
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... Show MoreThe approval of the federal general budget in Iraq is one of the most important competencies of the legislative authority , Being one of the important financial and monetary policy instruments on which the state depends for its economic growth , Hence, the obstruction of the approval of the federal budget due to sectarian quotas, the absence of national interest, and the emergence of bargaining processes between political parties belonging to the regions and sectarianism , As well as the absence of economic plans and programs as a result of non-cognition and understanding of the nature of its supposed political system applied in Iraq and the absence of specialists would le
... Show MoreThe theatrical image represents one of the tools of communication with the other to create a communicative language that is produced and transmitted by the actor and his body through the theatrical space to convey the meaning in all its forms and types. The actor is concerned with the composition and construction of these images. My girl, the image is fragmented and multiple and different. Therefore, based on the foregoing, the researcher has divided his research into four chapters, representing the (methodological framework). First, the research problem, which is manifested in the following question (what is the structure of the fragmented image of the actor's performance? The Iraqi playwright), and secondly: the importance of the resea
... Show MoreReceipt date: 2/2/2021 accepted date: 4/6/2021 Publication date: 12/31/2021
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The approval of the federal general budget in Iraq is one of the most important competencies of the legislative authority , Being one of the important financial and monetary policy instruments on which the state depends for its economic growth , Hence, the obstruction of the approval of the federal b
... Show MoreAbstract
The space occupied by the dialogic imperative in the language is a very wide range, as it is present in most of the speeches received by the recipient, and this is not limited to dialogues. That the literary discourse is a dialogical and fulfillment imperative, as the implication is related to the implicit connotations, as if the implication covers the indirect actions of the speech act theory.