Asthma is a chronic disease characterized by inflammatory events in the airways, that makes breathing a hard process in these patients. Angiotensin II (AngII) is important regulator for aldosterone production. Also, it participates in inducing reactive oxygen species (ROS) and inflammatory events. Angiotensin-converting enzyme (ACE) is responsible for the production of AngII. We hypothesised that ACE and AngII participate in the progression of asthma by increasing ROS production and inflammatory processes. Thus, we evaluated the level of AngII, the activity of ACE, and the level of malondialdehyde (MDA) as indicators for oxidative stress in 60 asthmatic male patients and 30 non-asthmatic male control. An asthma control test (ACT) was estimated for each patient to determine their controllable state. The levels of AngII and MDA and the activity of ACE were all elevated significantly in asthmatic patients. AngII is a risk factor for the progression of asthma with OR of 1.551 (1.203-2.001 CI 95%) for poor controlled patients. Also, ACE has been observed as a risk factor for the progression of asthma with OR of 1.386 (1.117-1.720 CI 95%). Moreover, AngII was correlated positively with MDA and ACE activity. Also, the value of ACT was correlated negatively with AngII level and ACE activity. In conclusion, AngII plays a vital role in the severity of asthma through the overactivity of ACE. The increase in AngII levels in asthmatic patients allows for the overproduction of ROS and increased inflammatory events, that are ultimately responsible for the deteriorations in the airways.
