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Effect of uricol® and food with different samafurantin® doses on secondary pharmacokinetic parameters by applying urinary data
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Introduction: Nitrofurantoin (NFT) is abroad spectrum bactericidal antibiotic. The bioavailability of NFT is affected by many factors. Samafurantin® tablets containing 50 mg NFT were manufactured by Samarra drug industry. Urinary excretion studies were employed since; the urinary tract is the main site of NFT action and excretion. Objective: The objective of the study was to investigate the effect of Uricol® and food on secondary pharmacokinetic parameters of Samafurantin® tablets with different doses by applying urinary data. Methods: Twelve healthy male volunteers participated in this study. Urine samples were collected from each volunteer after overnight fasting at a specified time intervals which considered as a blank sample for measuring urine pH of urine. After that, volunteers were randomly divided into two groups (G1 and G2) each of six. Group 1 was administered 100 mg of NFT (Two tablets of 50 mg Samafurantin®) while, G2 was administered 200 mg of NFT (Four tablets of 50 mg Samafurantin®) as a single oral dose. Both groups administered the dose on an empty stomach (fasting), along with one Uricol® of 5 g sachet on fasting, and on full stomach after eating a standard breakfast after 1-week washout period between each experiment and another. For each experiment, urine samples were collected from each volunteer from 0.25 to 7 h post dosing. In addition, the volume of each void urine sample was measured. Results: Both groups (G1 and G2) showed only slight differences in the pH of urine after administration of Samafurantin® as compared with that of the blank. While, the pH of urine for both groups was higher after administration of Samafurantin® tablets along with Uricol® 5 g. In both groups, each of Uricol® and food exhibited no significant differences (P < 0.05) in secondary pharmacokinetic parameters of NFT; the rate constant of elimination (Kel) and absorption (Ka) and consequently their half-life (t0.5 el and t0.5 abs) as long as the drug followed first-order kinetics. While significant differences (P < 0.05) were observed for maximum excretion rate (ExRmax), cumulative amount excreted in urine (CAe) and CAe as percentage of the dose. This could be attributed to the pH-change of urine by Uricol® which alkalinized the urinary and kidney tract or delaying gastric emptying by food. Same observations were attained when comparing G1 with G2 after administration of NFT on fasting. Conclusions: Administration of Samafurantin® tablets at higher doses, along with Uricol® or with food increases secondary pharmacokinetic parameters related to the rate and extent of absorption and elimination without significant changes in their corresponding rate constants and half-lives. © 2018 Drug Invention Today.

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Publication Date
Thu Dec 20 2007
Journal Name
Journal Of Planner And Development
The impact of decentralization on regional development
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As regional development, as a matter of course, poses a number of systemic, scientific and political problems. While the issue of development is primarily at the national level to the limits of World War II in the industrialized world and to the 1960s borders in most Third World countries, the increasing awareness of regional disparities has led to the regional issue Were taken into consideration in the early 1960s and 1970s in most industrialized and developing countries alike. The local issue was only introduced in the early 1980s. The awareness of regional disparities and the fact that the regions do not have the same potential and that some regions have the resources to enable them to develop, grow and develop, unlike other r

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Publication Date
Sun Jun 01 2014
Journal Name
Baghdad Science Journal
On Higher N-Derivation Of Prime Rings
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The main purpose of this work is to introduce the concept of higher N-derivation and study this concept into 2-torsion free prime ring we proved that:Let R be a prime ring of char. 2, U be a Jordan ideal of R and be a higher N-derivation of R, then , for all u U , r R , n N .

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Publication Date
Wed Feb 22 2023
Journal Name
Iraqi Journal Of Science
More on the Minimal Set of Periods
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Let M be a n-dimensional manifold. A C1- map f : M  M is called transversal if for all m N the graph of fm intersect transversally the diagonal of MM at each point (x,x) such that x is fixed point of fm. We study the minimal set of periods of f(M per (f)), where M has the same homology of the complex projective space and the real projective space. For maps of degree one we study the more general case of (M per (f)) for the class of continuous self-maps, where M has the same homology of the n-dimensional sphere.

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Publication Date
Wed Jan 01 2020
Journal Name
Cogent Engineering
On the computational aspects of Charlier polynomials
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Publication Date
Fri Feb 01 2013
Journal Name
Journal Of Applied Research And Technology
Effectiveness of Wavelet Denoising on Electroencephalogram Signals
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Publication Date
Tue Sep 01 2020
Journal Name
Baghdad Science Journal
On The Normality Set of Linear Operators
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            In this paper, the Normality set  will be investigated. Then, the study highlights some concepts properties and important results. In addition, it will prove that every operator with normality set has non trivial invariant subspace of  .

 

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Publication Date
Tue Jun 30 2020
Journal Name
Iraqi Journal Of Market Research And Consumer Protection
THE ROLE FEDERAL BOARD OF SUPREME AUDIT IN THE ENVIRONMENTAL MONITORING IN ACCORDANCE WITH INTOSAI STANDARDS: THE ROLE FEDERAL BOARD OF SUPREME AUDIT IN THE ENVIRONMENTAL MONITORING IN ACCORDANCE WITH INTOSAI STANDARDS
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The worsening of environmental problems has led to them being addressed by many entities, the most important of which are the top regulators. Federal Board of supreme audit Office is one of the most important regulators in Iraq. The problem of the research was the fundamental question of the extent to which the Federal Financial Supervisory Office was committed to implementing and exercising environmental control over the audited ones. The refore, the research was based on the main objective of questioning the role of the Federal Financial Supervisory Office in the exercise of environmental control and the compliance of those under its control, by identifying the antosai standards for environmental control, particularly the stand

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Publication Date
Wed May 07 2025
Journal Name
Applied Science And Engineering Progress
Optimizing Methyl Orange Degradation via Electro-Fenton with Copper Foam Cathode: A Comparative Approach Using Iron Waste vs. Iron Salts and Exploring Catalyst and Cathode Durability
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The use of foam electrodes as a cathode has proven its efficiency in wastewater treatment. In this study, methyl orange (MO) was treated by Electro-Fenton technology (EFT) using a copper foam (Cf) as a cathode. EFT was an advanced strategy for MO degradation, which accomplished excellent degradation efficiency (%ReMO) exceeded 98% over 35 min treatment period at prime conditions using 0.124 mM of iron salts (FeSO4.7H2O), 0.3 LPM of air flow, 0.2 mA/cm2 of current density (CD), and initial pH of 3.0. The outcomes showed that the air flow rate had the main impact on the %ReMO. Furthermore, the contribution of anodic oxidation (AO) to dye removal was investigated to distinguish its role relative to the EFT mechanism, revealing that the MO degr

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Publication Date
Wed Mar 15 2023
Journal Name
Iran. J. Ichthyol
Histological study of lingual papillae on the tongue of the adult Iraqi domestic cat, Felis catus
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The results of this study showed that the tongue of the adult Iraqi domestic cat is divided into three regions of apex, body and root. The dorsal surface of all regions possesses five types of lingual papillae, two mechanical which are filiform and cylindrical papillae, while the other three types are taste papillae which are foliate, fungiform and circumvallate papillae, while these papillae are absent on its ventral surface. The histological examination of all tongue areas revealed that it consisted of three tunica, the tunica mucosa and the tunica submucosa (the lamina propria) and the tunica muscularis. The tunica mucosa consisted of the epithelial lining, which is a stratified squamous epithelial tissue covering the lingual papillae, a

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Publication Date
Sun Jul 17 2022
Journal Name
Al–bahith Al–a'alami
Features of news coverage during Covid-19 crisis: Content analysis on a sample of global news accounts on Twitter
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This study aims to analyze the messages of a number of global news outlets on Twitter. In order to clarify the news outlets tactics of reporting, the subjects and focus during the crisis related to the spread of the Covid-19 virus. The study sample was chosen in a deliberate manner to provide descriptive results. Three news sites were selected: two of the most followed, professional and famous international news sites: New York Times and the Guardian, and one Arab news site: Al-Arabiya channel.

A total of 18,085 tweets were analyzed for the three accounts during the period from (1/3/2020) to (8/4/2020). A content analysis form was used to analyze the content of the news coverage.   The results indicate an increase in th

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