Synthesis, Identification, Theoretical Study, and Effect of the New Heterocyclic System from Ciprofloxacin Derivatives on the Activity of Some Liver Enzymes

Amaal S. Sadiq; Zahraa T. Khudhair; Selvana A. Yousif; Wasan A. R. Mahmood

doi:10.21123/bsj.2022.7502

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Publication Date

Mon Dec 05 2022

Journal Name

Baghdad Science Journal

Volume

19

Issue Number

6

DOI

10.21123/bsj.2022.7502

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Synthesis, Identification, Theoretical Study, and Effect of the New Heterocyclic System from Ciprofloxacin Derivatives on the Activity of Some Liver Enzymes

Ciprofloxacin

Liver enzymes

Mannich reactions

Spectrum

Synthesis

Amaal S. Sadiq

Zahraa T. Khudhair

Selvana A. Yousif

Wasan A. R. Mahmood

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The target of this study was to synthesize several new Ciprofloxacin drug analogs by providing a nucleophilic substitution procedure that provides new functionality at the carboxylic group location. The analogs were synthesized, designed, and characterized by 1HNMR, and FTIR. The synthetic path began from the reaction of ciprofloxacin drug with morpholine to give compound[B], ciprofloxacin derivative was linked with a variety of primary and secondary amines to give compounds[B1-B9]. The above-mentioned prepared compounds [B3 and B5] were applied to liver enzymes, and the increase in the activity of these enzymes was observed. In addition, a theoretical study was conducted to study the energies and properties of the prepared compounds.

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Publication Date

Thu Jun 11 2026

Journal Name

Journal Of Studies And Researches Of Sport Education

The effect of using the educational bag on the level of learning some offensive skills with the epee weapon

The effect of using the educational bag on the level of learning some offensive skills with the epee weaponDr. Lamia Hassan Al-Diwan

D. Fatima Abdel-Maliki

Dr. Kholoud Laith Abdel Karim2005 Technical and technological development has been increasing day after day and has included all areas of life

including the educational process

which has benefited from technologies such as (computer

video

and pictorial models) in introducing them as tools to aid the learning process. Educational packages have proven their effectiveness in education as they prepare learners with different areas of experience. Sensory audio-visual

through which the learner acquires different educational experiences through interaction

practice

participation

and communication with the data of the surrounding environment through the diversity of knowledge sources that suit his inclinations and needs. The research aimed to prepare an educational bag to teach some offensive skills in the epee weapon. And to find out the effect of using the proposed educational bag on the level of learning some offensive skills in the epee weapon. We hypothesized that the proposed educational package has a positive impact on the level of learning some offensive skills with the epee weapon. There were statistically significant differences in testing the level of learning some offensive skills with the epee weapon between the post-tests of the experimental and control groups

and in favor of the experimental group. The researchers used the experimental method to suit the nature of solving the research problem

and the research sample was chosen intentionally from the girls’ fencing club players (beginners) in the governorate. Basra for the year 2005. The number of players was (16)

which represented the entire study population. The experiment was conducted in the sports hall of the South Oil Sports Club in Basra. We concluded that the educational package has a positive impact on the level of learning some offensive skills in the epee weapon. There were statistically significant differences in the learning level test for some offensive skills in the epee weapon between the experimental group and the control group in the post-tests and in favor of the experimental group. We recommended the necessity of using the proposed educational curriculum to learn some offensive skills in the epee weapon in fencing lessons or in sports clubs. Adopting modern techniques in training

teaching or teaching fencing skills and searching for new methods. Conducting similar studies on other skills or different samples.Keywords: educational bag

offensive skills with an epee weapon

fencing game. Teaching methods. Basra Girl Sports ClubLamya Hassan Aldewan [email protected] of Basra - College of Education and Sports Scienceshttps://orcid.org/0000-0003-0377-6915 Keywords educational bag

offensive skills with an epee weapon

fencing game. Teaching methods. Basra Girl Sports Club

‏Lamyaa

Fatima

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Publication Date

Thu Jan 11 2018

Journal Name

Iosr Journal Of Pharmacy And Biological Sciences

Study the effect of hot aqueous extract of beetle cocoon Larinus maculatus F. on some physiological parameters in male albino mice

cocoon

extract

glucose

lipid profile

mice

Eqbal

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Abstract: The study aimed to investigate the effect of oral administration of hot aqueous extract of beetle cocoon Larinus maculatus Faldermann, in a two doses 50 and100mg/Kg/B.wt for 3 and 6 weeks respectively on the levels of serum glucose, weight of body, and lipid profile in male mice Mus musculus. The results revealed that there was a significant (p<0.05) decrease in serum glucose level was dose and period dependent. Weight of body also reduced significantly (p<0.05) with doses and period dependent. The lipid profile level significantly (p<0.05) decreased in dose and period’s manner in each of Total cholesterol (TC), Triglyceride (TG), High Density Lipoprotein- (HDL), Low Density Lipoprotein (LDL), and Very Low Density Lipoprotei

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Publication Date

Tue Dec 01 2009

Journal Name

Journal Of Economics And Administrative Sciences

Building a strategic perspective on the system of governance and measuring the level of its performance Survey study at the University of Basra

بناء منظور إستراتيجي لنظام الحوكمة

Building a strategic perspective on the system of governance

مسلم علاوي

محمد حسين

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The Local and Global Corporations are suffering of managerial and financial corruption phenomena, which leads them to loss and bankruptcy. So, it is necessary to search for tools which help prevent phenomena like this, and one of these tools is (corporate governance) which represent controlling tool that contribute in reducing corruption. this study aims at modifying (corporate governance system)in order to make it suitable with Iraqi government Corporations. the study depend upon main hypothesis which is (the performance level of the strategic perspective of governance system is depending upon work according to the perspective dimensions itself. From the main conclusions:-It is possible to building a strategic perspective

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Publication Date

Thu Jun 11 2026

Journal Name

Al-fatih Journal

Effect of resistance training on the development of marital some elements of physical fitness

م.د

أ.د

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يشهد العالم تقدما في كافة مجالات الحياة المختلفة وتزداد الحياة صعوبة يوما بعد يوم, ويزداد البحث في كافة المجالات التي تعمل على خدمة الإنسان ولقد طال هذا التقدم النشاط الرياضي ,فقد يكون لتطور التدريب الرياضي وتنوع أساليبه الدور الكبير في تحقيق اللياقة البدنية التي تعد إحدى أهم الأهداف التي يرمي إليها الدرس في كلية التربية الرياضية . واللياقة البدنية تستمد أهميتها من كونها إحدى مكونات اللياقة الشاملة التي بدو

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Publication Date

Thu May 18 2023

Journal Name

Journal Of Engineering

Experimental and Theoretical Investigation of Noise Effect in Centrifugal Fan Impeller

centrifugal blower

noise

frequency

rotational speed

static pressure

flow rate

Manal Hadi

Muna Sabah

Amina Hmoud

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In this work a study was made in centrifugal fan blower to investigate the effect of impeller blade design on sound pressure level (SPL). Shroud and unshroud impeller of nine blades are used. The sound generation from flow inside the test rig at different positions was displayed by using spectral analyzer. The experiments were carried out in anechoic chamber with small holes in its walls, under ambient condition about (25-27) C ° to avoid the effect of temperature on the sound pressure level. The results showed that (SPL) decreased with the increase of distance from the source about (3-4)dB when distance varied about (0.8-1.06)m, and the (SPL) decreased with the decrease of velocity about (8-12)dB when velocity varied between (13000-260

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Publication Date

Fri Sep 25 2020

Journal Name

International Journal Of Drug Delivery Technology

Synthesis, Antibacterial, and Molecular Docking Study of Novel 2-Chloro-8-Methoxy-3-Aryl-[1,3] Benzoxazine Derivatives using Vilsmeier Reagent

Shaimaa Abed

Dhuha Faruk

Raied

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Reducing of ethyl 4-((2-hydroxy-3-methoxybenzylidene)amino)benzoate (1) afford ethyl 4-((2-hydroxy-3-methoxybenzyl)amino)benzoate (2). Reaction of this compound with Vilsmeier reagent affords novel 2-chloro-[1,3] benzoxazine ring (3). The corresponding acid hydrazide of compound 3 was synthesized from reaction of compound (3) with hydrazine hydrate. Newly series of hydrazones (5a–i) were synthesized from reaction of acid hydrazide with various aryl aldehydes. Antibacterial activity of the hydrazones was secerned utilizing gram-negative and gram-positive bacteria. Compound (5b) and (5c) exhibited significant antibacterial ability against both gram-negative and gram-positive bacteria, while the compounds (5a) showed mild antibacteri

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(3)

Publication Date

Tue Oct 22 2019

Journal Name

Scientia Pharmaceutica

Design, Synthesis, and Docking Study of Acyl Thiourea Derivatives as Possible Histone Deacetylase Inhibitors with a Novel Zinc Binding Group

Duraid H.

Mohammed

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Histone deacetylase inhibitors with zinc binding groups often exhibit drawbacks like non-selectivity or toxic effects. Thus, there are continuous efforts to modify the currently available inhibitors or to discover new derivatives to overcome these problems. One approach is to synthesize new compounds with novel zinc binding groups. The present study describes the utilization of acyl thiourea functionality, known to possess the ability to complex with metals, to be a novel zinc binding group incorporated into the designed histone deacetylase inhibitors. N-adipoyl monoanilide thiourea (4) and N-pimeloyl monoanilide thiourea (5) have been synthesized and characterized successfully. They showed inhibition of growth of human colon adenoc

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(22)

(13)

Publication Date

Thu Jul 02 2020

Journal Name

International Journal Of Drug Delivery Technology

Synthesis, Antibacterial and Molecular Docking Study of Novel 2-Chloro-8-Methoxy-3-Aryl-[1,3] Benzoxazine Derivatives Using Vilsmeier Reagen

dhoha

...Show More Authors

Reducing of ethyl 4-((2-hydroxy-3-methoxybenzylidene)amino)benzoate (1) afford ethyl 4-((2-hydroxy-3-methoxybenzyl) amino)benzoate (2). Reaction of this compound with Vilsmeier reagent affords novel 2-chloro-[1,3] benzoxazine ring (3). The corresponding acid hydrazide of compound 3 was synthesized from reaction of compound (3) with hydrazine hydrate. Newly series of hydrazones(5a–i) were synthesized from reaction of acid hydrazide with various aryl aldehydes. Antibacterial activity of the hydrazones wassecerned utilizing gram-negative and gram-positive bacteria. Compound (5b) and (5c) exhibited significant antibacterial ability against both gram-negative and gram-positive bacteria, while the compounds(5a) showed mild antibacterial activit

Publication Date

Thu Jun 11 2026

Journal Name

Sciences Journal Of Physical Education

The effect of proposed changes for the rotation and throwing phases on some kinematic variables and the achievement of U20 throwers Shot put.

Zeina

Dr.

...Show More Authors

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Publication Date

Wed Mar 10 2021

Journal Name

Baghdad Science Journal

Antimicrobial Activity of Locally Synthesized Carbon Nanosphere on Some Pathogenic Species of Bacteria and Parasites

Antimicrobial Activity

Bacteria

Carbon Nanospheres

Cytotoxicity

Parasites.

Ali

Abdulqader

Shaimaa

Mohammad

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Antibacterial activity of CNSs against Staphylococcus aureus and Escherichia coli was estimated. Higher inhibition zone of 18 mm and 20 mm were observed against S. aureus and E.coli, respectively, at a concentration of 2 mg/ml of carbon nanosphere after 24 hrs of incubation at 37 ºC. In vitro cytotoxicity experiment was performed on two parasite strains of Leishmania donovani and Leishmania tropica by using MTT assay. L. donovani revealed more sensitiv to the CNSs than L. tropica. An intermediate level of cytotoxicity of 51.31 % was observed when 2.4 mg/ml of CNSs was incubated with L. donovani, while weak cytotoxicity of 37.20 % was shown when the

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