Lasmiditan (LAS) was formulated as a nanoemulsion based in situ gel (NEIG)with the aim of improving its oral bioavailability via application intranasally. The solubility of LAS in oils, emulsifiers, and co-emulsifiers was determined to identify nanoemulsion (NE)components. Phase diagrams were constructed to identify the area of nanoemulsification. LAS NE was formulated using the spontaneous nanoemulsification method. Four NEs (F19, F24, F31, and F34) containing 7-15 % oleic acid (OA) as an oily phase, 40-55% labrasol (LR), and transcutol (TC) as emulsifier mixture at (1:1), (2:1), (3:1), and (1:2) ratio with 30-53 % (w/w) aqueous phase, having suitable optical transparency of 95–98%, globule size of 104-140 nm and polydispersity of 0.253–0.382 were selected for ex vivo permeation study. F31 with the highest flux value (2.32 ± 0.01 mg/cm2.min) relative to the other NEs. It achieves an enhancement ratio of 3.3 as compared to LAS aqueous suspension (8% LAS) also it achieves a significantly higher value of permeability coefficient. F31 was selected for the incorporation of different percentages of pH-sensitive in situ gelling polymer (Carbopol 934) to prepare NEIGs 4,5 and 6. The gel strength, pH, gelation time, and viscosity were predicted for the prepared NEIGs. In vitro release and ex vivo, nasal permeation were determined for NEIG5, which exerts comparable release and permeation values as F31 with more residence time in order to overcome the normal nasal physiological clearance.
In this paper, the complex of Lascoux in the case of partition (3,3,2) has been studied by using diagrams ,divided power of the place polarization ) (k ij ,Capelli identites and the idea of mapping Cone .
Many studies have focused on identifying and classifying freshwater fishes in Iraq, concerned with describing, organizing, and drawing up a list of freshwater fishes in Iraq or the Tigris and Euphrates rivers. Within the most recent updates at the beginning of 2023, 53 native freshwater and 20 exotic (alien or introduced) fish species are recorded and described. This study reviewed the database of morphology and molecular studies of freshwater fish in Iraq and reported species while surveying the fish fauna at different water bodies of the country from 2010 to the beginning of 2023. In conclusion, 29 species (about 40.3%) of all 72 fish species in Iraq still need to be available information on their molecular data.
Regulations of changes in Sharia policy
Variables include jurisprudential rulings that may be subject to change, alteration and interpretation, depending on the mujtahid’s view of the ruling, or changing it and switching to another view, and the variables are the crucial issues that befell the nation of Islam. It was not neglected by Islamic legislation, but rather the setting of controls that took into account in every incident the norms, interests and purposes.
This study focuses on the relative frequency of Streptococcus pneumoniae in children with culture-proven bacterial meningitis. The epidemiology has been investigated with clinical and laboratory findings in The Central Public Health Laboratory, Iraq from April to September, 2010. From (138) samples , (55) cases (39.85 %) were diagnosed by physician as bacterial meningitis, (23) cases (16.66 %) as viral menginitis , (18) cases (13.04 %) as different medical cases (e.g febrile convulsion , meningoencephalitis , epilepsy …etc) and (42) cases (30.43 %) as unidentified medical cases. For bacterial meningitis S.pneumoniae was isolated from (10) cases (18.18 %) only. The median age for bacterial meningitis was (130.75) month and the predomina
... Show MoreBackground: Fibromyalgia is a functional disorder of growing importance characterized by chronic widespread musculoskeletal pain. It frequently affects women of child bearing age. Infertility is failure to achieve pregnancy within a 12 month period for sexually active individuals under 35 years of age and failure to conceive within a 6 months period for those over 35 years, which can have a major psychosocial impact on the affected person’s life.
Objectives: To estimate the prevalence of fibromyalgia among a sample of infertile women; and to study its relationship with age, length of marriage, duration and type of infertility.
Patients and Methods: A cross-sectional stu
... Show MoreBackground: Dietary supplementation is a common strategy to achieve a specific health status or performance benefit. The aim of this study was to describe the use of dietary supplement in Iraqi genders.
Patients and Methods: several questions on dietary supplement use were asked as a part of single performed on 112 female and 247 women aged 35–74 years in 2021 .n = 359) ,reported the frequency and prevalence of supplement use by sex and type of supplement .
Results: the mean percentage of dietary supplement use varied among female and men. Use was higher in women than in men. Vitamins, minerals were the predominant types of supplements reported, but the
... Show MoreBackground: vomiting is a very common symptom of disease in childhood, it occurs both in gastrointestinal and non-gastrointestinal diseases.
Objectives: Our aim of the study was to find out the causes of vomiting in different age group, the improper management of vomiting in daily practice and to emphasis on the usefulness of imaging study in the diagnosis.
Methods: A prospective study was carried out on patients presented with vomiting admitted to Children Welfare Teaching Hospital from the first of Dec. 2001 to the end of April 2002 .The age ranged between early neonatal periods to 12 years of age.
Reults: A total of 100 child were included in this study,(65) male (35) female male to female ratio
Background: Echinococcus granulosus is a one major species of medical and public health importance which causes cystic echinococcosis.Hydatid disease is able to modulate antiparasite immune responses, persist and flourish in humans.
Objective: The main objective of this study is to diagnostic value for hydatidosis and to identify the prevalence in human in two different areas of Baghdad city which include urban and rural areas. Evaluating hydatid fluid antigen and hydatid cyst wall antigen for diagnosis of cystic echinococcosis(CE). preparation ELISA kit for detecting specific antibodies in patients and relative sera is considered as an important step in determining the recurrent case after surgical opera
Smoking is one of the biggest pests in societies and is one of the main threats to human health as the problem goes beyond the smoker and the non smoker around it and is transmitted through the air and produces what is known as passive smoking.
Scientific studies and medical research confirm that at least 90% of patients with oral, pharyngeal, laryngeal, and other cancers are among smokers. It is known that the risk of these cancers among smokers increases as the amount of smoking increases. That the incidence of these malignant tumors among smokers rises between 6 to 10 times the incidence in non-smokers, Recent scientific research has proved beyond doubt that tobacco contains precursors, active carcinogens, activated cancer cel
... Show MoreThe basis of criminalization hi the penal code is the protection of rights whether the rights are related to human life or its property or the rights related to the protection of public property any attack on these rights is a crime the crime does not take place unless there is a physical and moral corner In addition the criminal intent of the offender must be available to the offender ie that he has knowledge of all the crimes of the crime as one of the elements of the intention But what if the person was wrong during the commission of the act the elements of the crime or all of it does this affect the criminal intent of the perpetrator or not since the importance of organizing the provisions of error and the impact of it wh
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