Diabetic foot ulcer (DFU) or Lower limb ulcers are one of the major complications caused by diabetes mellitus especially when patients fail to maintain tight glycemic control. DFU is linked to multiple risk factors along with the genetic factors and ethnicity which play a significant role in the development of DFUs through their effects on multiple aspects of the pathophysiological process. This narrative review aimed to summarize all the previous studies within the last ten years associating gene polymorphism and DFU. Polymorphism associated with vascular endothelial growth factor (rs699947), the G894T polymorphism of the endothelial nitric oxide synthase gene, interleukin-6–174 G>C gene polymorphism, heat shock protein 70 gene polymorphism, the apolipoprotein E gene polymorphism, Sirtuin 1 (sirt1) polymorphisms (rs12778366 and rs3758391), hypoxia-inducible factor -1 alpha exon 12 mutation, toll-like receptor gene (thr399ile polymorphism), the effect of both monocyte chemoattractant protein-1 (MCP-1) –2518A/G and the vascular endothelial growth factor (VEGF) –634g/c polymorphisms were summarized in this review. The results of all these studies indicating that screening for Polymorphisms might be helpful for early screening and prevention of DFU through their regulatory function on the transcription activity of the genes. Additional studies should be conducted in larger and different populations and ethnic regions to confirm the results of all previous studies mentioned in this review.
The need for optical fibers has emerged for its ability to transmit information with less attenuation and over long distances. In this work, four optical fibers with core radii from 1 μm to 4.75 μm in steps of 1.25 μm and a numerical aperture of 0.17 were studied and their modes properties have been calculated at a wavelength of 633 nm by using RP Fiber Calculator (free version 2022). Also, the effect of increasing the core radius on these properties has been studied. Multimode fibers can be obtained when the radius of the fiber core is large compared to the operating wavelength of the fiber which is less than the cutoff wavelength of the mode. Otherwise, a single-mode fiber is obtained. It has been concluded that all the calculated p
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In this research been to use some of the semi-parametric methods the based on the different function penalty as well as the methods proposed by the researcher because these methods work to estimate and variable selection of significant at once for single index model including (SCAD-NPLS method , the first proposal SCAD-MAVE method , the second proposal ALASSO-MAVE method ) .As it has been using a method simulation time to compare between the semi-parametric estimation method studied , and various simulation experiments to identify the best method based on the comparison criteria (mean squares error(MSE) and average mean squares error (AMSE)).
And the use
... Show MoreThe traveling salesman problem is addressed in this paper by introducing a distributed multi-ant colony algorithm that is implemented on a Raspberry Pi cluster. The implementation of a master and eight workers, each running on Raspberry Pi nodes, is the central component of this novel technique. Each worker is responsible for managing their own colony of ants, while the master coordinates communications among workers’ nodes and assesses the most optimal approach. To put the newly built cluster through its paces, several datasets of traveling salesman problem are used to test the created cluster. The findings of the experiment indicate that a single board computer cluster, which makes use of multi-ant colony algorithm, is a via
... Show MoreIn this work, the technique of attenuation of gamma ray to calculate the density of comet nucleus materials (C/2009 P1 (GARRADD) at different range of energy (0.2- 0.9 MeV). also, the single scattering model for gamma rays has been assumed that photons reaching the detector with scattered only once in the material. The program has been designed and written in FORTRAN language (77 – 90) to calculate the density for molecules using Monte Carlo method was used to simulate the scattering and absorption of photons in semi- infinite material. Gamma ray interacts with the matter by three mainly interactions: Photoelectric effect, Compton scattering and Pair production (electron and positron). On the 137Cs source energy (662 keV), Compton scat
... Show MoreLet be an infinite dimensional separable complex Hilbert space and let , where is the Banach algebra of all bounded linear operators on . In this paper we prove the following results. If is a operator, then 1. is a hypercyclic operator if and only if D and for every hyperinvariant subspace of . 2. If is a pure, then is a countably hypercyclic operator if and only if and for every hyperinvariant subspace of . 3. has a bounded set with dense orbit if and only if for every hyperinvariant subspace of , .
Incremental sheet metal forming is a modern technique of sheet metal forming in which a uniform sheet is locally deformed during the progressive action of a forming tool. The tool movement is governed by a CNC milling machine. The tool locally deforms by this way the sheet with pure deformation stretching. In SPIF process, the research is concentrate on the development of predict models for estimate the product quality. Using simulated annealing algorithm (SAA), Surface quality in SPIF has been modeled. In the development of this predictive model, spindle speed, feed rate and step depth have been considered as model parameters. Maximum peak height (Rz) and Arithmetic mean surface roughness (Ra) are used as response parameter to assess th
... Show MorePhotonic Crystal Fiber Fabry–Perot Interferometers (FPI) based on Surface Plasmon Resonance (SPR) was investigated in this paper in order to detect changes in photonic crystal fiber sensitivity with increasing temperature. FPI is composed of a PCF (ESM-12) solid core spliced with a single-mode fiber (SMF) on one side and a 40nm thick gold Nano film on the other. In order to obtain the SPR curve, the end of PCF can be spliced with the side of SMF before covering the gold film on the PCF. SPR results are included in the suggested sensor, based on the conclusions of the investigations. Resolution (R) is 0.0871, Signal-to-Noise Ratio (SNR) is 0.1867, a figure of merit (FOM) is 0.0069, and sensitivity (S) is 1.1481 . This sensor proposed is s
... Show MoreCloud computing has gained considerable attention in academia and industry in recent years. The cloud facilitates data sharing and enables cost efficiency, thus playing a vital role today as well as for the foreseeable future. In this paper, a brief discussion the application of multi-tenant and load-balancing technologies to cloud-based digital resource sharing suitable for academic and digital libraries is presented. As a new paradigm for digital resource sharing, a proposal of improving the current user service model with private cloud storage for other sectors, including the medical and financial fields is offered. This paper gives a summary of cloud computing and its possible applications, combined with digital data optim
... Show MoreMachine scheduling problems (MSP) are considered as one of the most important classes of combinatorial optimization problems. In this paper, the problem of job scheduling on a single machine is studied to minimize the multiobjective and multiobjective objective function. This objective function is: total completion time, total lead time and maximum tardiness time, respectively, which are formulated as are formulated. In this study, a mathematical model is created to solve the research problem. This problem can be divided into several sub-problems and simple algorithms have been found to find the solutions to these sub-problems and compare them with efficient solutions. For this problem, some rules that provide efficient solutio
... Show MoreSingle-input Multiple-output Signals Third-order Active-R Filter for different Circuit Merit Factor Q Configuration is proposed. This paper discusses a new configuration to realize third-order low pass, band pass and high pass. The presented circuit uses Single-input Multiple-output signals, OP-AMP and passive components. This filter is useful for high frequency operation, monolithic IC implementation and it is easy to design .This circuit gives three filter functions low-pass, high-pass and band-pass. This filter circuit can be used for different merit factor (Q) with high pass band gain. This gives better stop-band attenuation and sharper cut-off at the edge of the pass-band. Thus the response shows wider pass-band. The Ideal value of thi
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