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Abstract Background: Timely diagnosis of periodontal disease is crucial for restoring healthy
periodontal tissue and improving patients’ prognosis. There is a growing interest in using salivary
biomarkers as a noninvasive screening tool for periodontal disease. This study aimed to investigate
the diagnostic efficacy of two salivary biomarkers, lactate dehydrogenase (LDH) and total protein,
for periodontal disease by assessing their sensitivity in relation to clinical periodontal parameters.
Furthermore, the study aimed to explore the impact of systemic disease, age, and sex on the accuracy
of these biomarkers in the diagnosis of periodontal health.
Materials and methods: A total of 145 participants were categorized into three groups based
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