Objectives: Recently, there have been important advances in the clinical application of targeted hybrid near-infrared (NIR) fluorescent-radioactive tracers. ICG-99mTc-nanocolloid, for example, is already being used by some centres for sentinel lymph node biopsy in head and neck cancer. The radioactive component allows imaging at depths which would not be possible with NIR alone and, once exposed, the NIR fluorescence reporter can be imaged at very high resolution. Gamma detection is currently carried out with a separate hand-held gamma camera or with a non-imaging probe. Visualisation of NIR fluorescence during surgery requires a dedicated NIR camera, several of which are available commercially. We describe a novel hand-held hybrid NIR-gamma small field of view camera, capable of displaying co-aligned images from both modalities, which can be fused into one image or viewed separately. This study is a preliminary investigation of the performance of the fluorescence component of this camera, including phantom studies and first images from a preclinical pilot study. Methods: The hybrid camera consists of a 1500 µm thick thallium doped caesium iodide columnar (CsI:Tl) scintillator coupled to an electron multiplying charged coupled device (EMCCD). A 1.0mm diameter tungsten pinhole collimator gives a 40mm x 40mm nominal field of view for an 8mm x 8mm CCD detection area. A fluorescence camera was aligned to provide the same field of view as the gamma camera with an LED ring as the excitation source. The performance of the fluorescence imaging was quantified in this study for the fluorophores ICG and IRDye800CW (CW800) using a range of bespoke phantom experiments. In vivo images were also obtained from a preclinical study of a targeted hybrid tracer (cRGD-CW800-TCO + TCO-DOTA-111In) in mice with HT29 colorectal cancer xenografts. RESULTS AND CONCLUSION: The portable hybrid camera prototype has been shown to successfully image dual NIR-gamma tracers using both in vitro and in vivo experimental models. With further development, this camera could be used intraoperatively, offering the benefits of gamma imaging at depth in tissues and high resolution surface NIR fluorescence imaging in a single imaging system.
Data transmission in public communication system is not safe since of interception and improper manipulation by attacker. So, the attractive solution for these problems is to design high secure system that reduce the ability of attacker from getting sensitive information such as (account ID, passwords, etc.). The best way is combine two high secure techniques: steganography technique, which is the method of hiding any secret information like data, password and image behind any cover file and cryptography, which is convert the data to unreadable data. This paper suggests a crypto-stego authentication method to provide a highly secured authentication. The proposed method is utilized audio steganography and AES Cryp
... Show MoreIn this communication, introduce the split Mersenne and Mersenne-Lucas hybrid quaternions, also obtaining generating functions and Binet formulas for these hybrid quaternions and investigating some properties among them.
Voice denoising is the process of removing undesirable voices from the voice signal. Within the environmental noise and after the application of speech recognition system, the discriminative model finds it difficult to recognize the waveform of the voice signal. This is due to the fact that the environmental noise needs to use a suitable filter that does not affect the shaped waveform of the input microphone. This paper plans to build up a procedure for a discriminative model, using infinite impulse response filter (Butterworth filter) and local polynomial approximation (Savitzky-Golay) smoothing filter that is a polynomial regression on the signal values. Signal to noise ratio (SNR) was calculated after filtering to compare the results
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In this work the fabrication and characterization of poly(3-hexylthiophene) P3HT-metallic nanoparticles (Ag, Al). Pulsed Laser Ablation (PLA) technique was used to synthesis the nanoparticles in liquid. The Fourier Transformer Infrared (FTIR) for all samples indicate the chemical interaction between the polymer and the nanoparticles. Scanning Electron Microscopic (SEM) analysis showed the particle size for P3HT-AgNps samples between 44.50 nanometers as well the spherical structure. While for P3HT-AlNps samples was flakes shape. Energy Dispersive X-ray (EDX) spectra show the existing of amount of metallic nanoparticles.
With the freedom offered by the Deep Web, people have the opportunity to express themselves freely and discretely, and sadly, this is one of the reasons why people carry out illicit activities there. In this work, a novel dataset for Dark Web active domains known as crawler-DB is presented. To build the crawler-DB, the Onion Routing Network (Tor) was sampled, and then a web crawler capable of crawling into links was built. The link addresses that are gathered by the crawler are then classified automatically into five classes. The algorithm built in this study demonstrated good performance as it achieved an accuracy of 85%. A popular text representation method was used with the proposed crawler-DB crossed by two different supervise
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In this paper, the combined source coding with Multi Carrier Code Division Multiple Access (MC-CDMA) system is proposed, where the transmission of the compressed image produced from source coding through Additive White Gaussian Noise (AWGN) channel for a single user and multi users. In which the (MC-CDMA) system removes Inter Symbol Interference (ISI) and Inter Carrier Interference (ICI). The hybrid compression system of Discrete Cosine Transform (DCT) and predictive coding (PC) technique are integrated as a source coding. The simulation results indicates that the transmission system of a single user was much better than the transmission system of multi users. When the number of users increased, the Bit Error Rate (BER) increased. For a
... Show MoreDue to their attractive properties, silver nanowires (Ag-NWs) are newly used as nanoelectrodes in continuous wave (CW) THz photomixer. However, since these nanowires have small contact area, the nanowires fill factor in the photomixer active region is low, which leads to reduce the nanowires conductivity. In this work, we proposed to add graphene nanoantenna array as nanoelectrodes to the silver nanowires-based photomixer to improve the conductivity. In addition, the graphene nanoantenna array and the silver nanowires form new hybrid nanoelectrodes for the CW-THz photomixer leading to improve the device conversion efficiency by the plasmonic effect. Two types of graphene nanoantenna array are proposed in two separate photomixer conf
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Three important electrode arrays in 2D imaging surveys were tested in this study through synthetic model to determine which array is the most successful in defining the vertical and horizontal geological structures. These arrays are Wenner-Schlumberger, Wenner and Dipole - dipole. The numerical modeling was created through vertical fracture zone and three separate cavities surrounded by horizontal layers. The results showed that the Wenner-Schlumberger is the most suitable electrode array when both vertical and horizontal structures are present in the subsurface. It is the best in imaging the vertical and horizontal contacts and represented these structures more accurately than the Wenner and Dipole-dipole arrays.