Objectives: Recently, there have been important advances in the clinical application of targeted hybrid near-infrared (NIR) fluorescent-radioactive tracers. ICG-99mTc-nanocolloid, for example, is already being used by some centres for sentinel lymph node biopsy in head and neck cancer. The radioactive component allows imaging at depths which would not be possible with NIR alone and, once exposed, the NIR fluorescence reporter can be imaged at very high resolution. Gamma detection is currently carried out with a separate hand-held gamma camera or with a non-imaging probe. Visualisation of NIR fluorescence during surgery requires a dedicated NIR camera, several of which are available commercially. We describe a novel hand-held hybrid NIR-gamma small field of view camera, capable of displaying co-aligned images from both modalities, which can be fused into one image or viewed separately. This study is a preliminary investigation of the performance of the fluorescence component of this camera, including phantom studies and first images from a preclinical pilot study. Methods: The hybrid camera consists of a 1500 µm thick thallium doped caesium iodide columnar (CsI:Tl) scintillator coupled to an electron multiplying charged coupled device (EMCCD). A 1.0mm diameter tungsten pinhole collimator gives a 40mm x 40mm nominal field of view for an 8mm x 8mm CCD detection area. A fluorescence camera was aligned to provide the same field of view as the gamma camera with an LED ring as the excitation source. The performance of the fluorescence imaging was quantified in this study for the fluorophores ICG and IRDye800CW (CW800) using a range of bespoke phantom experiments. In vivo images were also obtained from a preclinical study of a targeted hybrid tracer (cRGD-CW800-TCO + TCO-DOTA-111In) in mice with HT29 colorectal cancer xenografts. RESULTS AND CONCLUSION: The portable hybrid camera prototype has been shown to successfully image dual NIR-gamma tracers using both in vitro and in vivo experimental models. With further development, this camera could be used intraoperatively, offering the benefits of gamma imaging at depth in tissues and high resolution surface NIR fluorescence imaging in a single imaging system.
Numeral recognition is considered an essential preliminary step for optical character recognition, document understanding, and others. Although several handwritten numeral recognition algorithms have been proposed so far, achieving adequate recognition accuracy and execution time remain challenging to date. In particular, recognition accuracy depends on the features extraction mechanism. As such, a fast and robust numeral recognition method is essential, which meets the desired accuracy by extracting the features efficiently while maintaining fast implementation time. Furthermore, to date most of the existing studies are focused on evaluating their methods based on clean environments, thus limiting understanding of their potential a
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Extension of bandwidth for high reflectance zone for the spectral region (8-14pm) was studied adapting the concept of contiguous and overlapping high reflectance stacks. Computations was carried out using the modified characteristic matrix theory restricted to near-normal incidence of light on dielectric , homogenous and isotropic symmetrical stack. Certain precautions must be taken in the choice of stacks to avoid deep —reflectance minima from developing within the extended high reflectance region. Results illustrate that the techniques of extending the high reflectance regions are applicable not only to mirrors , but also to short-and long-edge filter and to narrow band pass filters.
One of the most Interesting natural phenomena is clouds that have a very strong effect on the climate, weather and the earth's energy balance. Also clouds consider the key regulator for the average temperature of the plant. In this research monitoring and studying the cloud cover to know the clouds types and whether they are rainy or not rainy using visible and infrared satellite images. In order to interpret and know the types of the clouds visually without using any techniques, by comparing between the brightness and the shape of clouds in the same area for both the visible and infrared satellite images, where the differences in the contrasts of visible image are the albedo differences, while in the infrared images is the temperature d
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Cancer constitutes a serious disease and a major health problem in worldwide, a lot of people were infected with this dangerous disease, Therefore, there must be attention to this disease through diagnosis and prevention there. In this study, we determined the relationship between the Cancer and the concentration of trace elements by comparing the concentration trace elements for infected and non-infected people. The trace elements concentrations to nails are one of the diagnostic criteria that easily to detect and dated this disease without any harm to the patient. Eight nails samples were collected from cancer-infected and eight samples from non-infected of the relatives of first-degree. All samples were measured by the concentrations
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Histidine was determined via measurement of total luminescence (i:e creation of chemiluminescence and insitu irradiation of released light to an acceptor fluorophore molecule to initiate fluorescence from fluorescien molecule in flat – spiral micro cell designed for this measurement . A detailed description of robust linear equation for the range of 0.002 – 0.05 mol.L-1 for a sample size of 70 µL with a correlation coefficient of 0.9879 and a coefficient of determination of 97.59% while for a quadratic model of the same concentration range was 0.9881 correlation coefficient and 97.63% coefficient of determination. Analysis of variance was conducted for both kinds of models . It indicated that their was no significa
... Show MoreThe ï¤-mixing of ï§ - transition in Er 168 populated in Er(n,n ) Er 168 168 ï‚¢ï§ reaction is calculated in the present work by using a2- ratio method. This method has used in previou studies [4, 5, 6, 7] in case that the second transition is pure or for that transition which can be considered as pure only, but in one work we applied this method for two cases, in the first one for pure transition and in the 2nd one for non pure transitions. We take into accunt the experimental a2- coefficient for previous works and ï¤-values for one transition only [1]. The results obtained are, in general, in agood agreement within associated errors, with those reported previously [1], the discrepancies that occur are due to in
... Show MoreIn this paper, new brain tumour detection method is discovered whereby the normal slices are disassembled from the abnormal ones. Three main phases are deployed including the extraction of the cerebral tissue, the detection of abnormal block and the mechanism of fine-tuning and finally the detection of abnormal slice according to the detected abnormal blocks. Through experimental tests, progress made by the suggested means is assessed and verified. As a result, in terms of qualitative assessment, it is found that the performance of proposed method is satisfactory and may contribute to the development of reliable MRI brain tumour diagnosis and treatments.
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We present the concept of maps Γ- periodi2 on Γ -near-ring S. Our main goal is to research and explore the presence and mapping traits such as h Γ –hom anti-Γ –hom, Γ –α-derivations of Γ -periodi2 on Γ- near-rings.