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INVESTIGATING THE EFFECT OF DIFFERENT GRADES AND CONCENTRATIONS OF PH‑SENSITIVE POLYMER ON PREPARATION AND CHARACTERIZATION OF LIDOCAINE HYDROCHLORIDE AS IN SITU GEL BUCCAL SPRAY
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Objective: The present study was aimed to develop a pH-triggered in situ gel for local release of lidocaine hydrochloride (lidocaine HCL) in the buccal cavity to improve the anesthetic effect of this amino amide drug which has very high water solubility. The formulations were introduced to the oral cavity as a spray to improve compliance and for easier administration.Methods: In this work, two grades of carbopol (934 and 940)-based in situ gel spray were designed. The formulations containing lidocaine HCl 5% were prepared by mixing different concentrations of carbopol with xanthan gum. Eight formulations were investigated and evaluated for gelation capacity, spray angle, volume of solution delivered per each actuation, rheological properties, and release kinetic model. Similarity factor (f2) was used for the comparison of dissolution profiles.Results: The prepared formulations undergo gelation after it had been actuated to the buccal cavity as a spray solution. The results showed that, as the concentration of polymer was increased, the release of drug decreased and the viscosity increased for both grades. The spray angle and volume of solution delivered per each actuation varied according to the composition of each formulation. The in situ gel containing 0.3% carbopol 934 and 0.2% xanthan gum regarded as a better candidate which had a good gelation and release property compared to other formulations. Drug release from optimized in situ gel spray followed Korsmeyer–Peppas model and was mediated by Fickian diffusion mechanism.Conclusion: Lidocaine HCl-loaded pH-sensitive in situ gel was successfully developed using carbopol 934 as polymer to be applied to the buccal cavity as spray solution for more effective anesthetic effect and painless treatment.

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Publication Date
Sun Apr 23 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Influence Activation Function in Approximate Periodic Functions Using Neural Networks
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The aim of this paper is to design fast neural networks to approximate periodic functions, that is, design a fully connected networks contains links between all nodes in adjacent layers which can speed up the approximation times, reduce approximation failures, and increase possibility of obtaining the globally optimal approximation. We training suggested network by Levenberg-Marquardt training algorithm then speeding suggested networks by choosing most activation function (transfer function) which having a very fast convergence rate for reasonable size networks.             In all algorithms, the gradient of the performance function (energy function) is used to determine how to

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Publication Date
Mon Jun 01 2009
Journal Name
Al-khwarizmi Engineering Journal
Breast Tumor Diagnosis Using Diode Laser in Near Infrared Region
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In the last years, new non-invasively laser methods were used to detect breast tumors for pre- and postmenopausal females. The methods based on using laser radiation are safer than the other daily used methods for breast tumor detection like X-ray mammography, CT-scanner, and nuclear medicine.  

      One of these new methods is called FDPM (Frequency Domain Photon Migration). It is based on the modulation of laser beam by variable frequency sinusoidal waves. The modulated laser radiations illuminate the breast tissue and received from opposite side.

      In this paper the amplitude and the phase shift of the received signal were calculated according to the orig

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Publication Date
Sun May 30 2021
Journal Name
Iraqi Journal Of Science
SOME RESULTS ABOUT GENERALIZED SEMIDERIVATIONS IN 3-PRIME NEAR-RINGS
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   The purpose of this paper is to extend some results concerning generalized derivations to generalized semiderivations of 3-prime near rings.

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Publication Date
Sun Jun 30 2019
Journal Name
College Of Islamic Sciences
Itentional deliberative in Surat Al-Zumar M. Sheeda Khader Karim
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This research deals with deliberative intentionality in its two dimensions, deliberative intent, direct, and indirect deliberative intent, and deliberative intentionality assumed great importance to ancient and contemporary scholars. The text, relying on deliberative intent as a methodology concerned with the study of language in usage, and the research focuses on direct deliberative intent through (the intent of acceptability, the intent of the presumption, the intent of the informational, the intent of interaction), and the indirect deliberative intent through (the intentionality of the case, the intent of the metaphor, The intent of the communicative impulse, the intent of the allusion,), and these deliberative elements activate and c

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Publication Date
Sat Nov 28 2020
Journal Name
Iraqi Journal Of Science
Using Affiliation Rules-based Data Mining Technique in Referral System
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Referral techniques are normally employed in internet business applications. Existing frameworks prescribe things to a particular client according to client inclinations and former high evaluations. Quite a number of methods, such as cooperative filtering and content-based methodologies, dominate the architectural design of referral frameworks. Many referral schemes are domain-specific and cannot be deployed in a general-purpose setting. This study proposes a two-dimensional (User × Item)-space multimode referral scheme, having an enormous client base but few articles on offer. Additionally, the design of the referral scheme is anchored on the  and  articles, as expressed by a particular client, and is a combination of affi

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Publication Date
Thu Mar 30 2017
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Single Dose Antibiotic Prophylaxis in Outpatient Oral Surgery Comparative Study
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         It is clear that correct application of antibiotic prophylaxis can reduce the incidence of infection  resulting from the bacterial  inoculation in a variety of clinical situations; it cannot   prevent  all  infections  any  more  than it  can   eliminate  all  established infections. Optimum  antibiotic   prophylaxis  depends on:  rational  selection  of the drug(s),  adequate  concentrations  of the  drug  in  the  tissues that  are at risk, and attention to  timing  of  administration.  Moreover,  the  risk  of

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Publication Date
Mon Jul 22 2019
Journal Name
Innovations In Pharmacy
Evaluate Factors Influencing Depression in Baghdad: Using Deck-Depression Inventory
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Objective: This study goal was to screen participants from different settings in Baghdad for depression using Beck Depression Inventory (BDI) scale and identify factors influencing the levels of depression. Methods: This cross-sectional study included a convenience sample of 313 people from four settings (teaching hospital, college of medicine, college of pharmacy, and high school) in Baghdad, Iraq. The participants were screened using paper survey relying on the BDI scale during spring 2018. Using multiple linear regression analysis, we measured the association between depression scores and six participant factors. Results: The overall prevalence of depression in our sample was 57.2%. Female participants had higher BDI

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Publication Date
Wed Mar 10 2021
Journal Name
Baghdad Science Journal
5'-nucleoridase activity in sera from iraq children with leukemia
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Enzyme activity were studied in the sera of children with leukemia than healthy children, where 31 cases were studied, including 21 cases of patients with acute lymphatic leukemia

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Publication Date
Fri May 01 2020
Journal Name
Journal Of Engineering
Building 1D Mechanical Earth Model for Zubair Oilfield in Iraq
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Many problems were encountered during the drilling operations in Zubair oilfield. Stuckpipe, wellbore instability, breakouts and washouts, which increased the critical limits problems, were observed in many wells in this field, therefore an extra non-productive time added to the total drilling time, which will lead to an extra cost spent. A 1D Mechanical Earth Model (1D MEM) was built to suggest many solutions to such types of problems. An overpressured zone is noticed and an alternative mud weigh window is predicted depending on the results of the 1D MEM. Results of this study are diagnosed and wellbore instability problems are predicted in an efficient way using the 1D MEM. Suitable alternative solutions are presented

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Publication Date
Tue Aug 31 2021
Journal Name
Iraqi Journal Of Science
Separation Axioms in Topological Ordered Spaces Via b-open Sets
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     This paper aims to define and study new separation axioms based on the b-open sets in topological ordered spaces, namely strong - -ordered spaces ( ). These new separation axioms are lying between strong -ordered spaces and - - spaces ( ). The implications of these new separation axioms among themselves and other existing types are studied, giving several examples and counterexamples. Also, several properties of these spaces are investigated; for example, we show that the property of strong - -ordered spaces ( ) is an inherited property under open subspaces.

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