Abrus precatorius L. is an important medicinal plant belonging to family Fabaceae. The present study was conducted to perform pre-clinical safety evaluation and study the pharmacological effects of the ethanolic seeds extract of A. precatorius in management of pain, psychiatric and neurological conditions. Acute toxicity was performed to study the general behavioural pattern of mice after treatment with the test extract (single doses of 1000, 2000, 3000,4000,5000 mg/kg, body weight) and sub-acute toxicity studies were performed to study the toxic effects of the test extract (1000,2000,3000 mg/kg, per os for 14 days) on different haematological parameters, body and organ weight and histopathology of liver and kidney. The toxicological evalua

This study was conducted to investigate the effects of high concentration of Mentha spicata on liver tissues. Fourteen mature male albino mice were used in this study and divided into two groups. Control group received 1 ml normal saline daily for 7days through oro- gastric tube. The remained animals received 1ml of aqueous extract of Mentha spicata daily for 7 days through oro-gastric tube. At the end of experiment, all animals were dissected. Liver Samples were fixed in 10% buffered formalin and embedded in paraffin. Sections were prepared and stained with hematoxylin and eosin. The slides were examined macroscopically. The results showed that coagulative degeneration, degeneration of hepatocy

In this study blood samples were collected from 150 newborns (NBs), In a period from 20082010, with blood groups A and B from mother’s blood group O positive and those who do not have any other reason for the jaundice..Of 150 NBs, 105 have blood group A and 45 with group B. And the male to female ratio was 1.7:1. The average of NBs age at the onset of jaundice was 19.02 hrs, it was earlier in blood group B and in newborns of first pregnancy. The average of serum bilirubin level at 24 hours was 5.70 mg/dl; there was no statistical value of the blood group and the sex of the NBs in the bilirubin level. Newborns had anemia at delivery in 12 cases, 6 of them were premature. Fifty one NBs were followed for late anemia and found 36 (70%) had

This study aims to evaluate the effect of aqueous extract stem of dried  of Senna Alexandrıa using male mıce  once daily at varying doses for 2 and weeks on hematological and histological changer in liver and kidney. In the acute toxicity aqueous extracted of dried stem of Senna Alexandrıa were administrated orally to mice up to 20-25 gr of body weight, in sub-acute study mice was daily administrated orally with same extraction at dose 500,1000,2000 mg/kg for 14 days . Hematological findings have shown in male group increase of RBC, HGB, HCT in increase of PIT   in group treated with 500mg/ kg of body weight.

Body weight was increase after application of extract at the dose of  1000 and 2000 mg/ kg . T

Evaluate the acute and chronic toxicity of Ruta Chalepensis aerial part aqueous extract used in folk medicine in Iraq in Albino Wistar male and female rats. The study of chronic toxicity at the doses 100, 300 and 600mg/kg body weight in male and female rats for 90 days, recorded no mortality. Treated animals showed a normal weight change compared with control. The parameters of male fertility showed a significant decrease in the weight of testis, epididymis and seminal vesicle as well as a reduction in the number and the motility of spermatozoids at treated groups by the doses 300 and 600 mg/kg body weight compared to control group.

The current study was designed to investigate the effect of Tilletia smut spores on histopathological changes in liver and kidney in mice. Twenty animals were divided into two equal groups, 10 mice each, control group fed on normal diet and the treated groups were fed on a mixture of 50% normal diet with 50% wheat infected with Tilletia for 30 days. Histopathological sections taken from liver and kidney treated with Tilletia revealed several alterations. The changes in liver included, multiple granulomatous lesions, area of coagulation necrosis, vacuolar degeneration in the cytoplasm of hepatocytes, proliferation of hepatocytes with formation of pseudolobull which initiates for procancer. Whereas in the kidney, the changes included

This study was carried out to study the toxic effect of smut wheat on male reproductive system of mice. The experimental study was performed in the laboratory using 20 mice, which divided into two groups, one group feed on normal diet, the other fed on a mixture of 50% normal diet with 50% smut wheat. A histopathological study was done on the testes of Mice fed on smut wheat for 30 days. The histopathological study revealed thickness of basement membrane of semiriferous tubule of mice, and desquamation of the sertoli cells and spermatogonium from the basement membrane of seminiferous tubule and has adversely effect on male fertility.