Researcher Image
فراس فالح حمودي جواد - Firas Al-Zubaydi
PhD - lecturer
College of pharmacy , Department of pharmaceuticals
[email protected]
Summary

Dr. Firas Al-Zubaydi received his BSc in Pharmacy from the University of Baghdad in 1998, his MSc in Pharmaceutical Sciences from the University of Jordan in 2004, and his PhD from Rutgers University in 2020. In addition to serving as a lecturer in the College of Pharmacy, he is a member of the American Association of Pharmaceutical Scientists (AAPS). His research interests include the formulation and evaluation of nano drug delivery systems, Enhanced stability, and in vivo efficacy by modifying the physicochemical properties of drugs using nanotechnology and prodrug or hydrophobic ion pairing approach, Evaluating the cryoprotective effect of melatonin against vancomycin-related acute kidney injury by assessing the mitochondrial function using several in vitro assays such as Sea horse assay, mitochondrial reactive oxygen species generation, and mitochondrial membrane potential. Identify and fix any issues regarding process inefficiencies. Mentored other personnel in the laboratory to coordinate research efforts for increased efficiency; identified various areas of interest among members to advance the pharmaceutical sciences; and trained graduate students. He has over 20 years of experience as an independent lecturer teaching several pharmaceutics courses in public and private universities.

Qualifications

Rutgers University, New Jersey, US, PhD, Pharmaceutical science 2013 - 2020

University of Jordan, Amman, Jordan, MSc, Pharmaceutical science 2001 - 2003

University of Baghdad, Baghdad, Iraq, BSc, Pharmacy 1993 - 1998

Responsibility

Taught, created exam questions and developed assessment for several courses for undergraduate pharmacy students in the Department of Pharmaceutics, like pharmaceutical technology, basic pharmacokinetics, physical pharmacy, and 2004 - 2023 industrial pharmacy. Mentored and supervised the graduation projects of undergraduate and graduate students. Participate as a reviewer for the Iraqi Journal of pharmaceutical Science (IJPS), and as a committee member in several academic and scientific committees.

Awards and Memberships

1- FAES/NCATS, Online Principles of Preclinical Translational Science, online course at FAES/NCATS 2020

2- Graduate student NIH CLINICAL CENTER, Online PRINCIPLES OF CLINICAL PHARMACOLOGY; NIH CLINICAL CENTER online course, COURSE YEAR (2017-2018). 2018

3- Graduate student NIH CLINICAL CENTER, Bethesda, MD Clinical and Translational Research Course for PhD Students at NIH CLINICAL CENTER. Bethesda, MD. (July 9-20, 2018).

4-Simulation-Plus, Piscataway, NJ GastroPlus Simulation and Modeling workshop at Rutgers University, New Jersey, US (December 5-6, 2016).

5-EVONIK, Piscataway, NJ 6th Symposium on Solubility Enhancement at EVONIK; Piscataway, NJ (May 7- 8, 2015).

5- EVONIK, Piscataway, NJ EUDRAGIT Compact Course at EVONIK; Piscataway, NJ (March 26, 2015).

Awards

1- NJPhast Graduate Scholarship May 2016

Research Interests

Designed innovative nano-formulations and processes for complex and challenging compounds to improve drug stability and in vivo efficacy, resulting in the publication of four articles in peer-reviewed journals. Enhanced the stability and in vivo efficacy by modifying the physicochemical properties of drugs using nanotechnology and prodrug or hydrophobic ion pairing approach Developed and validated HPLC/MS and UV/Vis methods for drug dissolution, stability studies, and quantify drug/prodrug in animal tissue Conducted in vitro synergy studies and developed codelivery nanoparticles for optimized synergistic antitumor drug combination. Actively involved in NIH grant submission/ progress reports and product development strategies. Participate in discovery and preclinical development project research team to inform and update the team on the status of all active scientific projects.

Academic Area

Pharmaceutical technology, basic pharmacokinetics, physical pharmacy, and industrial pharmacy.

Teaching materials
Material
College
Department
Stage
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Industrial Pharmacy II
كلية الصيدلة
الصيدلانيات
Stage 5
Teaching

Taught, created exam questions and developed assessment for several courses for undergraduate pharmacy students in the Department of Pharmaceutics, like pharmaceutical technology, basic pharmacokinetics, physical pharmacy, and industrial pharmacy. Mentored and supervised the graduation projects of undergraduate and graduate students.

Supervision

1- Higher Diploma in Pharmaceutics; “The Effect of Ethyl Cellulose on the Release of Doxycycline Hyclate from Lyotropic Liquid Crystalline of Glycerol Monooleate”, by student Zainab Qassim Jafar

Publication Date
Wed Aug 01 2018
Journal Name
European Journal Of Pharmaceutical Sciences
The effect of size and polymer architecture of doxorubicin–poly(ethylene) glycol conjugate nanocarriers on breast duct retention, potency and toxicity
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Publication Date
Sat Sep 01 2018
Journal Name
Journal Of Interdisciplinary Nanomedicine
Evaluation of intraductal delivery of poly(ethylene glycol)‐doxorubicin conjugate nanocarriers for the treatment of ductal carcinoma in situ (DCIS)‐like lesions in rats
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Abstract<p>Ductal carcinoma in situ is the most commonly diagnosed early stage breast cancer. The efficacy of intraductally delivered poly(ethylene glycol)‐doxorubicin (PEG‐DOX) nanocarriers, composed of one or more DOX conjugated to various PEG polymers, was investigated in an orthotopic ductal carcinoma in situ‐like rat model. In vitro cytotoxicity was evaluated against 13762 Mat B III cells using MTT assay. The orthotopic model was developed by inoculating cancer cells into mammary ducts of female Fischer 344 retired breeder rats. The ductal retention and in vivo antitumour efficacy of two of the six nanocarriers (5 kDa PEG‐DOX and 40 kDa PEG‐(DOX)<sub>4</sub>) were investigated based o</p> ... Show More
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Publication Date
Wed Jul 01 2020
Journal Name
Journal Of Controlled Release
Breast intraductal nanoformulations for treating ductal carcinoma in situ I: Exploring metal-ion complexation to slow ciclopirox release, enhance mammary persistence and efficacy
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Publication Date
Mon Feb 15 2021
Journal Name
Drug Delivery And Translational Research
Breast intraductal nanoformulations for treating ductal carcinoma in situ II: Dose de-escalation using a slow releasing/slow bioconverting prodrug strategy
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Publication Date
Thu Nov 21 2013
Journal Name
Pharmaceutical Development And Technology
Effect of ethylcellulose and propylene glycol on the controlled-release performance of glyceryl monooleate–mertronidazole periodontal gel
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