فاضل محمد لفتة
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Fadhel Lafta
PhD
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assistant professor
College of Science
,
Department of Biology
[email protected]
Summary
Disciplines Cancer ResearchGeneticsMolecular Biology Skills and expertise ApoptosisDNA MethylationFlow CytometryCell CulturePCRWestern Blot Analysis
Publication Date
Wed Oct 21 2020
Journal Name
British Journal Of Cancer
Epigenome-wide analysis reveals functional modulators of drug sensitivity and post-treatment survival in chronic lymphocytic leukaemia
Abstract<sec>
<title>Background
Methods
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Chronic lymphocytic leukaemia (CLL) patients display a highly variable clinical course, with progressive acquisition of drug resistance. We sought to identify aberrant epigenetic traits that are enriched following exposure to treatment that could impact patient response to therapy.
Epigenome-wide analysis of DNA methylation was performed for 20 patients at two timepoints during treatment. The prognostic significance of differentially methylated regions (DMRs) was assessed in independent cohorts of 139 and 1
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