Progesterone is highly used in pregnant women as therapeutic agent to maintain and support pregnancy. To explore the effects of progesterone usage allover gestation till 7days postnatally on mice offspring ovaries development and anogenital distance. Ten pregnant mice were equally divide into control group that was injected with sesame oil which is used as a solvent for progesterone and treated group that is daily intraperitoneally injected with progesterone (dissolved in sesame oil 1: 10) at dose 10.2 mg/kg (the equivalent human dose) all through gestation till7day postnatal then sacrificed and measuring the anogenital distance (the distance between anus and genital papilla). Histological slides were prepared, and Diameters of the ovary, primary oocyte and primordial follicles were measured and histopathological changes analysis was done. Progesterone administration cause significant increment (p> 0-05) in anogenital distance, significant decrement in primary oocyte diameter and primordial follicle diameter, with no significant difference in the ovary diameter. Histopathological changes were seen as hemorrhage, detachment of follicular cells from basement membrane with irregular arrangement and thickening or death of follicular cells, pyknosis of primary oocytes and vacculation. Stromal cells degeneration. The current study revealed that progesterone injection of mice with equivalent human dose during pregnancy is embryotoxic and teratogenic, may alter the female reproductive performance with virilizing the female genitalia. The benefit of progesterone as a therapies need to be proven before recommended as supportive treatment …
Vancomycin Staphylococcus aureus (VRSA) is a strain of S. aureus that is considered the main cause of bacterial skin and soft tissue infections. It has acquired resistance to vancomycin and represents a therapeutic challenge. The current study aimed to compare the possible therapeutic effects of VRSA bacteriocin (VRSAcin) on the treatment of skin infection in mice with those of an antibiotic (linezolid). The results showed that of the fifty swabs obtained from human skin wounds. One isolate was selected for VRSAcin extraction depending on its antibiotic resistance using an antibiotic susceptibility test.An agar well diffusion test was used to determine bacteriocin’s antibacterial activity, as well as its a minimum inhibitory concentration
... Show MoreTo find out the impact of maternal risk factors on the outcome of pregnancy in Baghdad city. A descriptive purposive study was carried out on 100 postpartum women who had delivered for 1 hr. to 24 hrs. ago . the study sample was selected from three hospitals in Baghdad city ( Baghdad teaching hospital ,Fatima Al-Zahra'a maternity and pediatric teaching hospital and Al-Yarmook teaching hospital),during the period from 25 Jan. to 25 Feb. 2006. The data were collected through the use of questionnaire format reviewing pregnants' records and personal interview and were analyzed by using descriptive and inferential statistical approaches. The finding revealed that maternal pregnancy complications had weak effects on pregnancy outcome , while mate
... Show MoreThis quasi-experimental study investigated generative AI (GenAI) tools—Copilot for chemistry and GitHub Copilot for mathematics—on academic achievement and sustainable professional development among 160 undergraduates (40 experimental/control per department) at the University of Baghdad’s Ibn Al-Haitham College of Education for Pure Sciences (2024–2025). Non-random assignment controlled for covariates. Pre/post validated tests (α ≥ .85; 15 MCQ + 5 essay items) measured outcomes. ANOVA revealed significant gains for experimental groups (p < .001, η2 = .41, Cohen’s d = 0.72 [95% CI: 0.45–0.98]). Chemistry excelled in affective domains; mathematics in cognitive/skills. Findings affirm GenAI’s domain-specific efficacy, prov
... Show MoreThis quasi-experimental study investigated generative AI (GenAI) tools—Copilot for chemistry and GitHub Copilot for mathematics—on academic achievement and sustainable professional development among 160 undergraduates (40 experimental/control per department) at the University of Baghdad’s Ibn Al-Haitham College of Education for Pure Sciences (2024–2025). Non-random assignment controlled for covariates. Pre/post validated tests (α ≥ .85; 15 MCQ + 5 essay items) measured outcomes. ANOVA revealed significant gains for experimental groups (p < .001, η2 = .41, Cohen’s d = 0.72 [95% CI: 0.45–0.98]). Chemistry excelled in affective domains; mathematics in cognitive/skills. Findings affirm GenAI’s domain-specific effica
... Show MorePsoriasis is a long-lasting autoimmune disease that is characterized by swollen skin patches. Normally, these skin patches are dark, swollen, itchy and scaly. The single application of the innate TLR7/8 ligand Imiquimod (IMQ) in mice easily induces a dermatitis that closely resembles human psoriasis, critically dependent on the axis of IL-23/IL-17. Artemisia dracunculus prepared as an ointment and has been used topically to mice before imiquimod application. The results of the current study showed that A. dracunculus ointment can significantly reduce psoriasis area and severity index in (A. dracunculus ointment + imiquimod group as compared with both control group and (vehicle ointment + imiquimod) group.
Background : In order for a tooth to erupt, two obvious requirements are needed. First, there has to be alveolar bone resorption of the bone overlying the crown of the tooth such that an eruption pathway is formed. Second, resorption of bony crypt and apposition of new one, third, there has to be a biological process that will result in the tooth moving through this eruption pathway.The amniotic sac contains a considerable quantity of stem cells. These amniotic stem cells are multipotent and able to differentiate into various tissues, which may be useful for human application. Receptor activator of nuclear factor kappa B ligand (RANKL) is concentrated on bone biology, more specifically bone metabolism. RANKL plays a vital role in osteoclast
... Show MoreAbstract: Background: Tribuls terrestris increases levels of various hormones in steroid family including testosterone, DEHA, and estrogen and for this reason improves sport performance, fertility in men and women, sexual function in men and women. There is, at present, lack of scientific confirmation of these supposed benefits. Therefore, this study aims to investigate the possible effect(s) of Tribuls terrestris on the mouse ovarian morphology and function, alone and in combination with other ovulation modulator agent (clomiphene citrate). Materials & Methods: A total of 49 sexually mature healthy Norway albino female mice were used in this study; 25 for pilot study and 24 for the experimental study. Experimental animals were divided
... Show Morehe present work, among other previous studies done in our lab, aimed to highlight the histopathological effect of S. xylosus peptidoglycan in comparison to LPS of E. coli. Materials and methods: One hundred and fifty urine specimens were collected from urinary tract infection patients visiting Baghdad hospitals. The histopathological effects of S. xylosus S24 peptidoglycan was studied in the urinary tract of female mice by injecting 5 animal groups at the following concentrations: 1000, 2000, 3000, 4000, and 5000 µg/mL. Another 5 groups were injected with 10, 25, 50, 75, and 100 ng/mL of E. coli (serotype 0128:B12) LPS. Results: Ten isolates were confirmed to be Staphylococcus xylosus. Histopathological study showed different pathological
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