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Application of Hydrophilic Lipophilic Difference Theory for Fenofibrate Formulation as a Self-Emulsifying Drug Delivery System
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Improved oral bioavailability of lipophilic substances can be achieved using self-emulsifying drug delivery systems. However, because the properties of self-emulsifying are greatly influenced by surfactant amount and type, type of oil used, droplet size, charge, cosolvents, and physiological variables, the synthesis of self-emulsifying is highly complex; consequently, only a small number of excipient self-emulsifying formulations has been developed so far for clinical use. This study reports a highly effective procedure for developing self-emulsifying formulations using a novel approach based on the hydrophilic-lipophilic difference theory. Microemulsion characteristics, such as the constituents and amounts of oil and surfactant electrolyte concentration and temperature, were optimized to produce high-quality self-emulsifying drug delivery systems. Furthermore, in vitro lipolysis and in vivo bioavailability studies of fenofibrate, a highly lipophilic oral drug, loaded self-emulsifying dosage form were conducted. The self-emulsifying drug delivery system used in this study comprised soybean oil, water with a specific salinity, sodium dioctyl sulphosuccinate as a surfactant, and orlistat as a lipase inhibitor. The hydrophilic-lipophilic difference-based approach involved fewer experiments and allowed for the development of an efficient self-emulsifying dosage form with a relatively low surfactant concentration when compared to previous works. The salinity and equivalent alkane carbon number were optimized, with the proper selection of the type and amount of surfactant, to obtain a bicontinuous microemulsion (Winsor type III) that can be fully diluted with water. In vitro lipolysis was investigated in fasting and feeding settings, which showed a significant dosage form digestion by lipase enzyme; orlistat was successfully used to overcome dosage digestion and drug precipitation problem. In vivo experiments in rats involved oral gavage with a self-emulsifying dosage form containing fenofibrate (20 mg/kg). The pharmacokinetic profile of fenofibric acid showed remarkable enhancement in the bioavailability (F-95%). These findings demonstrate that the hydrophilic-lipophilic difference approach is a practical, scalable, and easy technique for self-emulsifying drug delivery system formulation development. Keywords: HLD theory, fenofibrate, SEDDS, lipolysis

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Publication Date
Mon Feb 04 2019
Journal Name
Journal Of The College Of Education For Women
Most preference colours for Iraqi Femal clothes in university level and theire psychology efect
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Colour is part of human environ ment and is present almost every
where in cluding clothes.
Clours have positive and negative effects on the person's psychology.
Thus we can ask the following question: what are the clours preffered
by the Iraqi females in the university level and what is the lightness and purity
of these colours and their effect on their psychology?
In this research we included 563 Baghdad university female student for
the year 2005-2006.
The question are included anumber of qnestions that gave answers to
the research main objectives.

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Publication Date
Sat Dec 31 2022
Journal Name
Iraqi Geological Journal
Geochemical Criteria for Discriminating Shallow and Deep Environments in Oligocene-Miocene Succession, Western Iraq
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The geochemical study of the Oligocene-Miocene succession Anah, Euphrates, and Fatha formations, western Iraq, was carried out to discriminate their depositional environments. Different major and trace patterns were observed between these formations. The major elements (Ca, Mg, Fe, Mn, K, and Na) and trace elements (Li, V, Cr, Co, Ni, Cu, Zn, Ga, Rb, Sr, Zr, Cs, Ba, Hf, W, Pb, Th, and U) are a function of the setting of the depositional environments. The reefal facies have lower concentrations of MgO, Li, Cr, Co, Ni, Ga, Rb, Zr, and Ba than marine and lagoonal facies but have higher concentrations of CaO, V, and Sr than it. Whereas dolomitic limestone facies are enriched V, and U while depletion in Li, Cr, Ni, Ga, Rb, Sr, Zr, Ba, an

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Publication Date
Thu Apr 01 2021
Journal Name
Indonesian Journal Of Electrical Engineering And Computer Science
Pushing towards ehealth for iraqi hypertensives: an integrated class association rules into SECI model
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<span lang="EN-GB">This paper highlights the barriers that have led to a delay in the implementation of E-Health services in Iraq. A new framework is proposed to improve the E-Health sector using a SECI model which describes how explicit and tacit knowledge is generated, transferred, and recreated in organizations through main stages (socialization, externalization, combination and internalization). Class association rules (CARs) is integrated to mine the SECI model by extracting related rules which correspond to the medical advice. The proposed framework (SECICAR) can be done through a web portal to assemble healthcare professionals, patients in one environment. SECICAR will be applied to the hypertension community to show th

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Publication Date
Tue Feb 28 2023
Journal Name
Iraqi Journal Of Science
Solvability for Optimal Classical Continuous Control Problem Controlling by Quaternary Hyperbolic Boundary Value Problem
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    This work is concerned with studying the solvability for optimal classical continuous control quaternary vector problem that controls by quaternary linear hyperbolic boundary value problem. The existence of the unique quaternary state vector solution for the quaternary linear hyperbolic boundary value problem  is studied and demonstrated by employing the method of Galerkin, where the classical continuous control quaternary vector  is Known. Also, the existence theorem of an optimal classical continuous control quaternary vector related to the quaternary linear hyperbolic boundary value problem is demonstrated. The existence of a unique solution to the adjoint quaternary linear hyperbolic boundary value problem a

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Publication Date
Sun Jul 30 2023
Journal Name
Iraqi Journal Of Science
Using Visual Cryptography and hash function for Fragile Watermarking to Detect Electronic Document Forgery
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     Recent developments in technology and the area of digital communications have rendered digital images increasingly susceptible to tampering and alteration by persons who are not authorized to do so. This may appear to be acceptable, especially if an image editing process is necessary to delete or add a particular scene that improves the quality the image. But what about images used in authorized governmental transactions? The consequences can be severe; any altered document is considered forged under the law and may cause confusion. Also, any document that cannot be verified as being authentic is regarded as a fake and cannot be used, inflicting harm on people. The suggested work intends to reduce fraud in electronic documents u

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Publication Date
Mon Dec 14 2020
Journal Name
Baghdad Science Journal
Smart Flow Steering Agent for End-to-End Delay Improvement in Software-Defined Networks
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Publication Date
Thu Jul 01 2021
Journal Name
Journal Of Physics: Conference Series
Wireless Optimization Algorithm for Multi-floor AP deployment using binary particle swarm optimization (BPSO)
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Abstract<p>Optimizing the Access Point (AP) deployment is of great importance in wireless applications owing the requirement to provide efficient and cost-effective communication. Highly targeted by many researchers and academic industries, Quality of Service (QOS) is an important primary parameter and objective in mind along with AP placement and overall publishing cost. This study proposes and investigates a multi-level optimization algorithm based on Binary Particle Swarm Optimization (BPSO). It aims to an optimal multi-floor AP placement with effective coverage that makes it more capable of supporting QOS and cost effectiveness. Five pairs (coverage, AP placement) of weights, signal threshol</p> ... Show More
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Publication Date
Sat Jan 01 2022
Journal Name
Ssrn Electronic Journal
Highly Sensitive Fiber Brag Grating Based Gas Sensor Integrating Polyaniline Nanofiber for Remote Monitoring
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Publication Date
Wed Mar 15 2023
Journal Name
Journal Of The Turkish-german Gynecological Association
Obstetric and neonatal complications in large for gestational age pregnancy with late gestational diabetes
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Publication Date
Sun Oct 30 2022
Journal Name
Iraqi Journal Of Science
The Best Efficient Solutions for Multi-Criteria Travelling Salesman Problem Using Local Search Methods
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     In this research, we propose to use two local search methods (LSM's); Particle Swarm Optimization (PSO) and the Bees Algorithm (BA) to solve Multi-Criteria Travelling Salesman Problem (MCTSP) to obtain the best efficient solutions. The generating process of the population of the proposed LSM's may be randomly obtained or by adding some initial solutions obtained from some efficient heuristic methods. The obtained solutions of the PSO and BA are compared with the solutions of the exact methods (complete enumeration and branch and bound methods) and some heuristic methods. The results proved the efficiency of PSO and BA methods for a large number of nodes ( ). The proposed LSM's give the best efficient solutions for the MCTSP for

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