Ectopic growth of normal cells or debris originating from endometrium, the inner layer of female reproductive tube leads to endometriosis. The main symptoms are dyspareunia, dysmenorrhea, and sometimes chronic pelvic pain. Unfortunately, it has no cure or treatment, only symptoms relief medication or surgical removal. Endometriosis causes estrogen imbalance leading to intestinal bacterial estrobolome dysregulation and subsequent change in immune response. Our study aims to investigate the linkage between gut dysbiosis and immunological response in endometriotic mice. Balb/c mice were ovariectomized (OVX) 7 days before intraperitoneal transplantation of 2mm2 endometrial tissue from OVX donors to OVX- or intact ovary recipients. Colonic content was collected 2 weeks post transplantation for 16s rRNA pyrosequencing. Peritoneal exudate was collected and stained to determine the phenotype of infiltrating cells by flow cytometry. Results revealed a significant increase in the number of exudate cells, natural killer (NK) cells and myeloid derived suppressor cells (MDSCs) in endometriotic mice. Phylogenetic taxonomy showed an increase in the biomass of the bacteria in endometriotic OVX mice in comparison with endometriotic nonovariectomized mice. However, the abundance of Phylum Tenericutes, Order Clostridiales, Dehalobacterium sp. and Anaeroplasma sp. were decreased. Collectively, endometriosis changed estrogen metabolism and gut microbiota which resulted in the immune modulation. (Supported by NIH P01AT003961, R01AT006888, R01MH094755, P20GM103641, R01AI129788 and R01AI123947 to PN and MN, and MoHESR to AKM).
Benign prostatic hyperplasia (BPH) is one of the most common disease and major cause of morbidity in elderly men which may lead to bladder outflow obstruction and lower urinary tract symptoms (LUTS). Although sex steroid hormones play fundamental roles in prostate growth, their clinical significance is not completely clear. In the present study we assessed whether serum hormones levels as markers of prostate disease. This study includes (40) patients with benign prostatic hypertrophy and (40) control group with age rang (41-79) and (42-71) years respectively. The following biochemical investigations have been studied: Testosterone, Estradiol (E2), and Prostatic Specific Antigen (PSA) levels using ELISA method which correlated with t
... Show MoreOne hundred thirty seven Staphylococcus spp. isolates were isolated form one hundred fifty clinical specimens which were collected from several hospitals at Al-Sulaimaniya city. Seventy two Staphylococcus aureus isolates, 28 Staphylococcus epidermidis isolates and 37 isolates related to other coagulase negative staphylocci (S. chromogenes, S. lugdunensis, S. cohnii, S. saprophyticus, S. hominis, and S. haemolyticus constituted 3.60%, 2.20%, 2.90%, 2.90%, 6.60%, and 8.80%, respectively). Burn specimens represented the highest (P< 0.05) reservoir for S. aureus and S. epidermidis isolates. Staphylococci developed variable susceptibility to 4 antibiotics (cefoxitin; 30 μg, oxacillin; 1μg, methicillin; 5μg, and cefotaxime; 30 μg). Neve
... Show MoreExamining of 80 feces samples showed that 31 samples of the house and stray cats harbored either single or mixed infection with eight species of parasites and protozoa with a total infection rate 38.75 %.The results on parasite classes are: Toxocara cati (5%), Ancylostoma tubeforme (3.75%), Capillaria felis(3.75%), Isospora sp.(10%), Cryptosporidium parvum(3.75%), Cryptosporidium muris (6.25%), Toxoplasma gondi (3.75%), Giardia sp.(2.5%) infection from feces of cats that showed single, double and triple infections. Our findings revealed the risk for public health, thus preventive measures should be implemented.
In view of the huge and speedy development of the information and communications technology sectores which cover all the life aspects. The traditional government started to adopt the Electronic Government Concept to deliver the information, services and product marketing to the beneficiaries through the Internet and Computer system. The E-government became inevitable necessity that should be applied in every country wishes to face the Modern technical development.
E-government is not on alternative of the traditional government but a supporter which can increase its efficiency by keeping away from the routine and Beaurucratic complexity, this will save the efforts, increase achievement and reduce costs, in addition to Provide Man
... Show MoreBackground: Chronic periodontitis is an inflammatory disease that affects the supporting tissues of the teeth and it’s common among adults. Smoking is an important risk factor for periodontitis induces alveolar bone loss. Alkaline phosphatase enzyme is involved in the destruction of the human periodontium. It is produced by many cells such as polymorphonuclear leukocytes, osteoblasts, macrophages and fibroblasts within the area of the periodontium and gingival crevice. Osteocalcin is one of the most abundant matrix proteins found in bones and the only matrix protein synthesized exclusively there. Smaller Osteocalcin fragments are found in areas of bone remodeling and are actually degradation products of the bone matrix.The purpose of
... Show MoreTo assess the environmental pollution of the soil at north Baiji City, the concentration of As, Se, Cr, Co, Cu, Cd, Sb, Mn, Mo, Ni, Pb, V, U, Sr, Ba, Ag, Rb, Li, Sn, Bi, Tl and Zn were determined in 18 sites. Results showed that the range concentrations of metal in mg/kg were Mo (0.84-2.15), Cu (17.62-78.77), Pb (9.89-19.19), Zn (39.5-374.7), Ag (0.064-0.14), Ni (90.7-210), Co (12.8-26.6), Mn (407-863), As (4-7.1), Cd (0.18-0.37), Sb (0.38-0.77), Bi (0.06-0.17), V (74-281), Cr (128-287), Li (15.3-24.4), Tl (0.14-0.24), Sn (0.6-1.7), Rb (28-51.2), U (1.2-1.5), Se (0.3-0.6), Ba (173-310), Sr (218-1270). Based on enrichment factor (EF) of trace elements, Mo, Cu, Pb, Mn, Bi, U, V, Li, Sn, Rb, Ba and Tl were showed deficiency to minimal enric
... Show MoreDespite the multiplicity of institutions contributing to the decision-making process in the United States of America, they interact to crystallize positions regarding international and strategic situations. The formulation of the national security policy depends on a number of institutions that complement each other in order to achieve an advanced security situation. Thus, the decision reflects the process of interaction of the existing regulatory institutions. This is because the essence of the national security and achieving its requirements also stems from the existence of a coherent system of shared beliefs and principles in the American society. Besides, these elements are the bases for achieving
... Show MoreThe resistivity survey was carried out by using vertical electrical sounding (VES) and 2D imaging techniques in the northern Badra area, Eastern Iraq. Eleven VES points distributed on two parallel profiles and six 2D imaging stations were applied using long survey lines.
In general, two types of aquifers are recognized in the study area. The first is the Quaternary aquifer, which appears in all geological sections and inverse model of 2D imaging stations (2DS).This aquifer can be divided into upper and lower aquifers as shown in (2DS1), (2DS3), and (2DS4). Generally, the thickness of this aquifer ranges between (30-200 m) which occurs at a depth of (10-30m) according to geological sections, while its thickness ranges between (35-180m)
Radon concentrations are measured for water samples collected from twenty wells which were drilled in Hashimiya area in addition to twelve samples of surface water using Alpha Gaurd. 140 samples, 7 for each well, were collected represent wet season in continuous pumping and 20 samples, one for each well, were collected represent dry season. Concentration of radon in groundwater is many times of its concentration in surface water. The minimum concentration in groundwater is about (7) Bq/L and (5) Bq/L while the maximum concentration is about (31) Bq/L and (19) Bq/L in wet season and dry season respectively. The range of radon concentrations in river water is between (1.06) Bq/L and (1.21) Bq/L. This study has indicated that there is a flo
... Show More1,3,4-oxadizole and pyrazole derivatives are very important scaffolds for medicinal chemistry. A literature survey revealed that they possess a wide spectrum of biological activities including anti-inflammatory and antitumor effects.
To describe the synthesis and evaluation of two classes of new niflumic acid (NF) derivatives, the 1,3,4-oxadizole derivatives (compounds 3 and (4A-E) and pyrazole derivatives (compounds 5 and 6), as EGFR tyrosine kinase inhibitors in silico and in vitro.
The designed compounds were synthesized using convent