The purpose of this study is to evaluate the effect of hydrated lime addition methods as filler replacement on fatigue performance of Hot Mix Asphalt (HMA). Three types of addition methods of hydrated lime were introduced namely dry HL on dry aggregate and saturated surface aggregate above 3% and slurry HL on dry aggregate, ordinary Lime stone powder was reduced by three HL percentage (1.0, 2.0 and 3.0 %). The effect of different methods were investigated on the fatigue properties of HMA using, third-point flexural fatigue bending Test. Pneumatic Repeated Load System (PRLS) was carried out to establish the effect of hydrated lime on the fatigue failure criteria and to select the proper hydrated lime application methods on fatigue behavior of HMA mixtures. The fatigue functions for asphalt mixture with hydrated lime are obtained and compared, and it confirm that the fatigue property of asphalt mixture can be improved using all methods and the addition methods were exhibited different optimality for the result due to its effect . The test results were carried out through the performance analysis using Vesys 5W (2003) to study the long term effectiveness of hydrated lime effect.