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Mixture model-based association analysis with case-control data in genome wide association studies
Abstract<p>Multilocus haplotype analysis of candidate variants with genome wide association studies (GWAS) data may provide evidence of association with disease, even when the individual loci themselves do not. Unfortunately, when a large number of candidate variants are investigated, identifying risk haplotypes can be very difficult. To meet the challenge, a number of approaches have been put forward in recent years. However, most of them are not directly linked to the disease-penetrances of haplotypes and thus may not be efficient. To fill this gap, we propose a mixture model-based approach for detecting risk haplotypes. Under the mixture model, haplotypes are clustered directly according to their estimated disease penetrances. A theoretical justification of the above model is provided. Furthermore, we introduce a hypothesis test for haplotype inheritance patterns which underpin this model. The performance of the proposed approach is evaluated by simulations and real data analysis. The results show that the proposed approach outperforms an existing multiple testing method.</p>
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Publication Date
Tue Apr 28 2020
Journal Name
Iraqi Journal Of Veterinary Sciences
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Publication Date
Tue Sep 01 2020
Journal Name
Journal Of Engineering
Experimental Study on Heat Transfer and Flow Characteristics in Subcooled Flow Boiling in a Microchannel

The current study presents an experimental investigation of heat transfer and flow characteristic for subcooled flow boiling of deionized water in the microchannel heat sink. The test section consisted of a single microchannel having 300μm wide nominal dimensions and 300μm height (hydraulic diameter of 300μm). The test section formed of oxygen-free copper with 72mm length and 12mm width. Experimental operation conditions spanned the heat flux (78-800) kW/m2, mass flux (1700 and 2100) kg/m2.s at 31˚C subcooled inlet temperature. The boiling heat transfer coefficient is measured and compared with existing correlations. Also, the experimental pressure drop is measured and compared with microscale p

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Publication Date
Wed Nov 20 2024
Journal Name
Journal Of Baghdad College Of Dentistry
Periodontal condition in relation to nutritional status among kindergarten children in Al-Ramadi city/Iraq

Background: Nutrition can affect periodontal disease through contributing to microbial growth in the gingival crevice, affecting the immunological response to bacterial antigens and assisting the repair mechanism of the connective tissue at the local site after injury from plaque and calculus. The aim of this study was to assess the prevalence of Oral hygiene (plaque and calculus) and gingivitis in relation to age, gender and nutritional status. Materials and methods: The sample included (444) kindergarten children at age of (4 and 5 years old) males and females from urban areas in Al-Ramadi city. The assessment of nutritional status was performed using anthropometr

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Publication Date
Sun Apr 03 2005
Journal Name
Journal Of The Faculty Of Medicine Baghdad
PREVALENCE OF HIRSUTISM IN ADULT FEMALES IN GYNAECOLOGY OUT PATIENT CLINIC AT TIKRIT TEACHING HOSPITAL

Background: Hirsutism is a common clinical problem which causes a great distress to the patient, which true incidence is unknown . However it is more common among Mediterranian women who are usually more accepting of their condition .
Aim of study : To determine the prevalence of hirsutism among adult females attendins the gynaecology out patient clinic at tikrit teaching hospital.
Patients & Methods: A sample of 175 adult non pregnant women (married & un married) with age range (18-25) years was included in this study .All attending the Gynaecology out patient clinic in Tiktrit teaching Hospital from Jan-Oct. 1999 .A full medical history was obtained. then patient were examined for pattern and severity of hair gowth . Grad

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Publication Date
Sun May 26 2019
Journal Name
Iraqi Journal Of Science
Identification of Antibiotic-Resistant Genes in Salmonella Typhi Isolated From Typhoid Patient in Samawa City

A total of 100 blood samples taken from patients with suspected typhoid fever aged between (1-60) years, were involved in this study. Blood samples were cultured directly on brain heart infusion broth. After that sub cultured of isolates on MacConkey agar and XLD agar and S.S agar to find the Salmonella typhi then identified by the biochemical and antibiotic sensitivity test. Resistant genes were identified by using aacc2 gene and cat gene. Results showed that there was 7 Salmonella typhi isolates from blood culture, as well as, aacc2 gene success in amplification of 450bp fragment for amino glycoside resistant, while not improve amplification

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Publication Date
Mon Mar 07 2022
Journal Name
Book
Insights into developing curricula in mass communication departments and colleges in public and private universities

Technology developed at very rapid paces in the last decade of the twentieth century and what followed, especially communication technology, as the World Wide Web appeared in the mid-nineties of the last century, Facebook in 2004 and 2006, the mobile phone, 1993, 1994, and social networking sites. The other. These technological developments have had an impact on societies, whether among individuals in one country or among different peoples. The citizen in any part of the world has become a journalist who practices the work of a specialized or professional journalist, even if he does not know how to read and write, or has a low level of education, as he can now transmit events from wherever he is to the world, through his personal page, or v

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Publication Date
Sat Feb 01 2020
Journal Name
Journal Of Economics And Administrative Sciences
The Reality of Agricultural Policies and Their Role in Achieving Sustainable Agricultural Development in Iraq

   The Agricultural Policy is one of the most important tools adopted by the state to guide its economic and social activities through the delivery of suitable agricultural commodities to the consumer and in return to deliver agricultural inputs to the agricultural producers at the lowest possible cost to contribute in achieving a profit that helps the agricultural product to continue in the production process with the same efficiency and ambition. So as to help increase the contribution of the agricultural sector to GDP and achieve the best picture of sustainable agricultural development.

The research aimed at identifying the reality of agricultural policies and their role in achieving sustaina

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Publication Date
Sun Jun 02 2013
Journal Name
Baghdad Science Journal
Bacterial Isolates and Their Antibiograms of Burn Wound Infections in Burns Specialist Hospital in Baghdad

A total of 54 out of 67 (80.59%) of burn wound swab showed growth of one, or two, or three bacterial pathogens. Pseudomonas aeruginosa was the commonest pathogen, isolated in 48.14% of swab samples, followed by Klebsiella pneumoniae (31.48%), Staphylococcus aureus (27.77%), Acinetobacter baumanii (14.81%), Escherichia coli (7.40%), and Citrobacter freundii, Providencia stuartii, Enterobacter cloacae, with 1.85% isolation percentage for each. All bacterial isolates were tested against 19 antibiotics, and showed multi-drug resistance to 10 antibiotics, or more. The most effective antibiotics were the fifth-generation cephalosporin, ceftobiprole, and and antibiotic combinations, as Ceftazidime / clavulanic acid, and Cefoperazone /sulbactam, an

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Publication Date
Tue Jan 30 2018
Journal Name
Iraqi Journal Of Science
New Modulation Method in FSO Communication Using Different Wavelengths (650,532,405) nm in the Iraqi Weather

The FSO technique depends on the compatibility of the optical path between the transmitter and the receiver (line-of-sight) to transmit data between two points. FSO system uses the light to provide optical Contact to send and receive various data. This study shows the design of a new optical system for the transmission of voice through free space at wavelengths (650,532,405) nm within point-point technology for specified distances. What distinguishes this work is the quality of the reflection-based modulation based on the Doppler phenomenon. Also, it is interested in studying the different attenuation conditions of the atmosphere at the wavelengths used, in addition to the attenuation caused by the

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Publication Date
Sun Dec 15 2019
Journal Name
Journal Of Baghdad College Of Dentistry
Personality Types in relation to dental caries and salivary testosterone among teachers in Baghdad city

Background: Personality could be defined broadly as those characteristics of individuals that describe the pattern of feeling, cognition and behaving. Personality types can be measured by using one of personality type’s measures. Personality has been proposed to influence the oral health. The purpose of the present study was to assess the influence of Personality Types on caries experience in relation to salivary testosterone hormone among teachers in Baghdad city. Materials and Methods: Female teachers (n=534) of randomly selected schools were subjected to personality questionnaire using The Riso-Hudson Enneagram Type Indicator. Teachers were examined to estimate the caries experience according to the decayed-missing and filled i

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