The poultry industry is developing continuously and rapidly, this development takes several trends in the poultry industry, such as searching for new alternatives feed additives. The research focused on finding new alternatives feed additives, among these alternatives is Synoptic, which used to maximize the benefit of the two important compounds (probiotics and prebiotics) as these two compounds are considered one of the most alternatives feed additives, which have been used a lot in poultry feeding to maximize the value of these compounds, they were combined into one compound called synbiotic. Several studies confirm that the synbiotic effect on the intestine morphology, which, the ratio villus height and villus: crypt ratio in the small intestinal significantly increased (p < 0.05). This explains the improvement in growth performance and nutritional efficiency in most of the research that has found that synoptic influences growth performance traits. Other important effect for add synbiotic on diets is increase the benefit microorganism in the intestine and increase the competition with pathogenic bacteria, this will reduce the pathogenic bacteria, also the benefit bacteria secrete inhibitor substrate effect on the pathogenic microorganism. The previous studies confirm that the synbiotic increase the immunity, improve the health performance and reduce the mortality. In this chapter, we will discuss more details about synoptic in poultry feeding in terms of its components, physiological mechanism in the body and its effect on productive performance and immunity.