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Multiple Sclerosis is a Risk Factor for Hyperthyroidism and Interferon Beta Action on Thyroid Hormones via Novel Immuno-neuro-enzymological Mechanisms
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Objective : Multiple sclerosis (MS) is a common neurological disease deeply linked with the immune-inflammatory disorders whereas the term (multiple) mostly refers to the multi-focal zones of Inflammation caused by lymphocytes and macrophages infiltration besides oligodendrocytes death. Accordingly , the dysfunctional immune system able to damage myelin ( a pivotal component of the central nervous system ) which responsible for communication among neurons. The aim of the present study is to innovate a biochemical relationship between MS and thyroid hormones (THs) by highlighting immunological responses and also to examine the action of Interferon beta (IFNβ) drug on thyroid hormone (THs) and thyroid stimulation hormone (TSH). Materials and methods: Sixty (60) Iraqi women in the age ranged (36-43) years were enrolled in the present study, (30) of them were MS patients and the other (30) were healthy. Anyway, the protocol of the study involved four groups: G1 is a healthy control group, G2 involved untreated MS patients, G3 included the MS patients treated with IFNβ for (6) weeks and G4 composed of the same patients treated with IFNβ for (12) weeks. THs (T4 and T3) and TSH levels were determined in sera of all groups. Results: Data of the present study have reported that T4 level was highly significant increase in sera of G2 compared with G1 while it was significant and highly significant decreased in G3 and G4 respectively compared with G2, the difference between G4 and G1 and also between G4 and G3 was significant. T3 level was highly significant increase in sera of G2 compared with G1 but it was highly significant decreased in G3 and G4 compared with G2, the difference between G4 and G1 was non-significant while the difference between G4 and G3 was significant. Conversely, TSH level was highly significant decreased in G2 compared with G1 but it was highly significant increase in G3 and G4 compared with G2, the difference between G4 and G1 and also between G4 and G3 was highly significant. Conclusions : Interestingly , the present study is the first in Iraq reporting that MS may be a key risk factor for hyperthyroidism and also the first suggesting that IFNβ regulates THs biosynthesis via novel immuno-neuro-enzymological mechanisms regarding thyroid peroxidase (TPO) and iodothyronine deiodinase 1 (D1), meanwhile the present study indicates that IFNβ has an indirect antioxidant activity. Moreover, the present study provides a definite clarification for the changed NF kappa B level in MS. Remarkably, the present study reveals that IFNβ is more potent on T3 than T4 while it has less action on TSH.

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Publication Date
Sun Sep 01 2013
Journal Name
Journal Of Economics And Administrative Sciences
Compared Methods of Generating Both Gamma Distribution and Beta Distribution
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Beta Distribution

Abstract

             Gamma and Beta Distributions has very important in practice in various areas of statistical and applications reliability and quality control of production. and There are a number of methods to generate data behave on according to these distribution. and These methods bassic primarily on the shape parameters of each distribution and the relationship between these distributions and their relationship with some other probability distributions.    &nb

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Publication Date
Wed Nov 01 2023
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Assessment of ellagic acid action in 5-fluorouracil induced intestinal mucositis: Assessment of ellagic acid action in 5-fluorouracil induced intestinal mucositis
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The intestinal mucositis define as inflammation and ulceration in the gastrointestinal tract wall and in some case in the oral cavity these cause by treatment with antineoplastic drug like 5-fluorouracil and Irinotecan and other types of chemotherapeutics drugs , 5-Fluorouracil-induced intestinal mucositis (IM) is consider as one of the more common tumor issue .it cause series of undesirables symptoms like severe diarrhea ,abdominal pain , stomach uncomfortable and other. The aim of this current study to see how ellagic acid act to  Attenuates 5-FU-Induced Intestinal Mucositis and  Diarrhea in Mice . we induced the intestinal mucositis by injected the mice intraperitoneally in 5-fluorouracil about 50mg per kg daily for

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Publication Date
Fri Jun 30 2023
Journal Name
Iraqi Journal Of Science
Assessing the Potentiality of Using CXCL9 as A Predictive Biomarker for Acute and Chronic Toxoplasmosis, and Study the Correlation Between CXCL9, Toxoplasmosis and Thyroid Disorder in These Cases
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     Background:  Chemokine (C-X-C motif) ligand (CXCL9) has an important role recruiting the T-lymphocytes and immune response after infection by inducing T-cells accumulation around the areas associated with infections. However, this role is poorly known in relation with Toxoplasma gondii infection and also in association with thyroid hormones, which the present study is focused on. Methods: Eighty-seven women were included in this study for the period between September 2021 and February 2022. Blood samples of uninfected healthy pregnant, in addition to aborted and pregnant women infected with toxoplasmosis, were collected. Sera were then obtained and stored at -10°C. Toxo-latex agglutination test was done, followed by detec

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Publication Date
Fri Oct 01 2010
Journal Name
Iraqi Journal Of Physics
Investigation of Beta and Gamma Rays Total Interaction Cross Section and Effective Atomic Number for CR-39Nuclear Track Detector
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CR-39 is a solid state nuclear track detector (SSNTD) that has been used in many research areas. In spite of the assumption that the CR-39 detectors are insensitive to beta and gamma rays, irradiation with these rays can have significant effects on the detector properties. In this study, beta and gamma rays mass attenuation coefficients μ/ρ (cm2 g-1) for the CR-39 detector have been measured using NaI(Tl) scintillation spectrometer along with a standard geometrical arrangement in the energy region of (0.546-2.274) MeV beta rays and standard gamma sources having energy 0.356, 0.5697, 0.6617 and 1.063 MeV. The total atomic cross-section (σtot), total electronic cross-section (σT E) and the effective atomic number (Zeff) of gamma rays a

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Publication Date
Mon Oct 05 2026
Journal Name
Iraqi Journal Of Mechanical And Material Engineering
THE INFLUENCE OF FRICTION FACTOR ON THE COMBINED CONVECTIVE AND RADIATIVE HEAT TRANSFER IN A RECTANGULAR DUCT WITH INTERIOR CIRCULAR CORE
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Publication Date
Thu Apr 01 2021
Journal Name
Neuroquantology
Finding Most Stable Isobar for Nuclides with Mass Number (165- 175) against Beta Decay
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In the beta decay process, a neutron converts into a proton, or vice versa, so the atom in this process changes to a more stable isobar. Bethe-Weizsäcker used a quasi-experimental formula in the present study to find the most stable isobar for isobaric groups of mass nuclides (A=165-175). In a group of isobars, there are two methods of calculating the most stable isobar. The most stable isobar represents the lowest parabola value by calculating the binding energy value (B.E) for each nuclide in this family, and then drawing these binding energy values as a function of the atomic number (Z) in order to obtain the mass parabolas, the second method is by calculating the atomic number value of the most stable isobar (ZA). The results show

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Publication Date
Mon Jul 27 2026
Journal Name
Journal Of University Of Anbar For Pure Science
Comparison of Methods for The Determination of Beta-Lactam Drugs Using Different Analytical Methods
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Given the increasing global use of antibiotics, it has become necessary to examine and recognize their significance. An antibiotic formulation may contain one or more active components, depending on the antibiotic’s type and formulation. Antibiotics act exclusively against bacterial diseases and are ineffective against viral infections such as the common cold and influenza. The purpose of this review is to analyze the existing literature on the determination of antibiotics and to present the methods used for estimating specific antibiotics, including cephalexin, cloxacillin, piperacillin, nafcillin, and cefamandole, in medicinal preparations and biological fluids, such as blood and urine, from humans and animals. Verifying the quality of

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Publication Date
Thu Feb 01 2024
Journal Name
International Journal Of Biological Macromolecules
A novel designed nanofibrous mat based on hydroxypropyl methyl cellulose incorporating mango peel extract for potential use in wound care system
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Publication Date
Mon Jan 01 2018
Journal Name
Research Journal Of Pharmacy And Technology
The Relationship between Clinic Pathological Characteristics and Follicular Thyroid Lesion
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Study was done in the period between (2015–2017) in biology department in college of Education for pure science/Ibn Al-Haitham at Baghdad University and in Pathology department/college of medicine at Al-Nahrain University. The study was retrospectively designed. The clinicopathological parameters were obtained from patients’ admission case sheets and pathology reports (age, gender). The presents study included 120 patients having thyroid nodules, classified according to results of histopathology into 4 groups, 30 patients within each; the first group included patients with follicular adenoma, the second group included patients with follicular carcinoma, the third group included patients with follicular variant of papillary carcinoma (FV

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Publication Date
Thu Jan 04 2024
Journal Name
Journal Of Accounting And Financial Studies ( Jafs )
Measuring the impact of internal governance mechanisms on the quality of financial reports
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Abstract:

                The research aims to define the theoretical framework for corporate governance and its mechanisms and shed light on corporate governance in Iraq as well as the theoretical framework for the quality of financial reports and their relationship and the role of corporate governance in activating them. A commercial bank as a sample for the research, and a survey list was prepared to show the extent to which the research sample banks are committed to applying internal governance mechanisms. imposed on them by the local environment, which leads to improving the quality of financial reports for these banks.

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