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Abstract
Exotoxin A is the most lethal virulence factor produced by Pseudomonas aeruginosa. It inhibits elongation
factor-2 by ADP-ribosylation of EF2. This causes stop of the elongation of polypeptides. In recent study, the
effect of low concentration of exotoxin A on some important internal organs of mice was studied. Four groups
white mice were injected intraperitonialy with pure exotoxin A in the following manner 0.1, 0.2, 0.3, 0.4 ng\
animals. One mouse receives normal saline inrtaperitonialy as a control. After 72 hours the mice were killed and
four organs were taken, liver, spleen, lung and heart from each killed mice. Histological sections were made
from each organ and stained with hematoxylin and eosin stain then examined under mic
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